DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1824 and MDL2

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_015053.2	Gene:	MDL2 / 855858	SGDID:	S000006191	Length:	773	Species:	Saccharomyces cerevisiae

Alignment Length:	776	Identity:	241/776 - (31%)
Similarity:	381/776 - (49%)	Gaps:	124/776 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RLLVSNCGRSSDIFSRHLLQPTQQPLPRLQNAARLMRQHLRGTNAPQPPAIPPTNASRLLQTTRL 67
            ||.:...|...::.||          |||   |:|.....|....|        ::|:|:..:||
Yeast     5 RLPLLRLGICRNMLSR----------PRL---AKLPSIRFRSLVTP--------SSSQLIPLSRL 48

  Fly    68 LVWGGGSLAIGLGARSWWAGHRGAIV---HCEGSRL---------------AIRKEEEEEDTASE 114
            .:   .|.|:|          :..|:   .|..|:.               :.|....:|.:.::
Yeast    49 CL---RSPAVG----------KSLILQSFRCNSSKTVPETSLPSASPISKGSARSAHAKEQSKTD 100

  Fly   115 QHFDWKRLWTYLEPHLWE-LIGAVCAALIVAYINIRIPNLLGDLVNTLARYANTYVMD---PINN 175
            .:.|..||: .|....|: |:.|:....|...|.:.||.::|.:::||...:.:...|   ||
Yeast   101 DYKDIIRLF-MLAKRDWKLLLTAILLLTISCSIGMSIPKVIGIVLDTLKTSSGSDFFDLKIPI-- 162

  Fly   176 SFVKDVSKPASNLLSLY----MLQSGFTFMYIYLLSRVGEQMAAKMRQDLFTQIVVQDIAFFDEN 236
                 .|.|....||.:    ::.....|....||..:.|::.|::|.::..:.:.||..|||.:
Yeast   163 -----FSLPLYEFLSFFTVALLIGCAANFGRFILLRILSERVVARLRANVIKKTLHQDAEFFDNH 222

  Fly   237 RTGELVNRLTADVQDFKTSFKQFVSQGLRSAAQLIGGSISLFM---ISPHMAAIALASVPCVVMF 298
            :.|:|::||.:|......|..|.||.|:::   ||.|.:.:.|   :||.::.:.|...|.|:..
Yeast   223 KVGDLISRLGSDAYVVSRSMTQKVSDGVKA---LICGVVGVGMMCSLSPQLSILLLFFTPPVLFS 284

  Fly   299 MTYLGKKLRSLSKSSQAQAERATGVCEEALSNIRTVRSSACEYREMQLFEAETNEAARLAQKLGY 363
            .:..||::|:.||..|....:.|.|.||.||.|:||:|          |.||.||.:|      |
Yeast   285 ASVFGKQIRNTSKDLQEATGQLTRVAEEQLSGIKTVQS----------FVAEGNELSR------Y 333

  Fly   364 GIA---IFQ-----GLTN--FFLNTLV------LSTLFMGGHLMSTESLSPGALMAFLVASQGVQ 412
            .:|   |||     ..||  ||..|.:      |:.|..|.:|:....||.|.|.||::.::...
Yeast   334 NVAIRDIFQVGKTAAFTNAKFFTTTSLLGDLSFLTVLAYGSYLVLQSQLSIGDLTAFMLYTEYTG 398

  Fly   413 RSLAQGSILLGTMIRGMSAGSRVFEFLSLQPQVELLRGYIIPQERLHGEIRFENVSFAYPMQPDH 477
            .::...|.....:::|..|.||:||....:|.:....|:....:|  |.|.|::|||:||.:|..
Yeast   399 NAVFGLSTFYSEIMQGAGAASRLFELTDRKPSISPTVGHKYKPDR--GVIEFKDVSFSYPTRPSV 461

  Fly   478 LVLKDFSLTLRPGQTVALVGASGSGKSTIASLVERFYEPSAGNIKLDGYKLSDISPYWLRSNVLG 542
            .:.|:.:..:.||.:|.:||.||.||||||.|:.|:|.|:.|.|.:|...:|.::...||.:: |
Yeast   462 QIFKNLNFKIAPGSSVCIVGPSGRGKSTIALLLLRYYNPTTGTITIDNQDISKLNCKSLRRHI-G 525

  Fly   543 FIEQQPVLFGTSILENIRYG---KPDAGEEDVYAAARLSQSHDFVTALPDGYATHVGERGTQLSG 604
            .::|:|||...:|.:||.||   .|.  :|::.:.|:....|:|:|..|:.|.|.:|..||.|||
Yeast   526 IVQQEPVLMSGTIRDNITYGLTYTPT--KEEIRSVAKQCFCHNFITKFPNTYDTVIGPHGTLLSG 588

  Fly   605 GQRQRIAIARALLKNPRILILDEATSALDATSEAEVQKALDTVVQNR--TTLVIAHRLSTIRNAD 667
            ||:|||||||||:|.|.||||||||||||..||..:......:::::  |.:.|||||||||.::
Yeast   589 GQKQRIAIARALIKKPTILILDEATSALDVESEGAINYTFGQLMKSKSMTIVSIAHRLSTIRRSE 653

  Fly   668 LIVVL-DQGRVVETGKHDELMGK-RGLYFELVRQQER---RDIQEQVQAV---EDVVAVKE 720
            .::|| ..|.|||.||..||... .....:|:.::..   .|.|.|::.|   ||:...||
Yeast   654 NVIVLGHDGSVVEMGKFKELYANPTSALSQLLNEKAAPGPSDQQLQIEKVIEKEDLNESKE 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	208/615 (34%)
		ABC_membrane	137..415	CDD:279056	86/303 (28%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	105/244 (43%)
MDL2	NP_015053.2	3a01208	1..685	CDD:273363	232/745 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I944
eggNOG	1	0.900	-	-		E2759_KOG0058
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54509
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720