DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1824 and ABCB14

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_174122.1	Gene:	ABCB14 / 839694	AraportID:	AT1G28010	Length:	1247	Species:	Arabidopsis thaliana

Alignment Length:	632	Identity:	217/632 - (34%)
Similarity:	340/632 - (53%)	Gaps:	75/632 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 KEEEEEDTASEQHFDWKRL------WTYLEPHLWELIGAVCAALIVAYINIRIPNLLGDLVNTLA 162
            |:.:.||..|.....|:.:      |.|.   |...||||.|....|..::.:
plant   655 KDSKGEDLISSSSMIWELIKLNAPEWLYA---LLGSIGAVLAGSQPALFSMGL------------ 704

  Fly   163 RYANTYVMDPINNSFVKDVSKPASNLLS-------LYMLQSGFTFMYIYLLSRVGEQMAAKMRQD 220
            .|..|....|..:...::|.|.|...:.       :|:||.     |.|.|  :||::.:::|..
plant   705 AYVLTTFYSPFPSLIKREVDKVAIIFVGAGIVTAPIYILQH-----YFYTL--MGERLTSRVRLS 762

  Fly   221 LFTQIVVQDIAFF--DENRTGELVNRLTADVQDFKTSFKQFVSQGLRSAAQLIGGSISLFMISPH 283
            ||:.|:..:|.:|  |||.||.|.:.|.||....:::....:|..:::.:..|......|..|..
plant   763 LFSAILSNEIGWFDLDENNTGSLTSILAADATLVRSAIADRLSTIVQNLSLTITALALAFFYSWR 827

  Fly   284 MAAIALASVPCVV-------MFMT-YLGKKLRSLSKSSQAQAERATGVCEEALSNIRTVRSSACE 340
            :||:..|..|.::       :|:. :.|...|:.|        |||.:..||:||||||.:.:.|
plant   828 VAAVVTACFPLLIAASLTEQLFLKGFGGDYTRAYS--------RATSLAREAISNIRTVAAFSAE 884

  Fly   341 YREMQLFEAETNEAARLA------QKLGYGIAIFQGLTNFFLNTLVLSTLFMGGHLMSTESLSPG 399
            .:..:.|..|.::..:.|      ...|||::......::.|....:|.|.........:|:.
plant   885 KQISEQFTCELSKPTKSALLRGHISGFGYGLSQCLAFCSYALGLWYISVLIKRNETNFEDSIK-- 947

  Fly   400 ALMAFLVASQGVQRSLAQGSILLGTMIRGMSAGSRVFEFLSLQPQVELLRGYIIPQERL----HG 460
            :.|..||.:..|..:||    |...:::|..|...||..|..:.::...:    |..||    .|
plant   948 SFMVLLVTAYSVAETLA----LTPDIVKGTQALGSVFRVLHRETEIPPDQ----PNSRLVTHIKG 1004

  Fly   461 EIRFENVSFAYPMQPDHLVLKDFSLTLRPGQTVALVGASGSGKSTIASLVERFYEPSAGNIKLDG 525
            :|.|.|||||||.:|:..:.|:.:|.:..|:::|:||.|||||||:..|:.|||:||.||:.:||
plant  1005 DIEFRNVSFAYPTRPEIAIFKNLNLRVSAGKSLAVVGPSGSGKSTVIGLIMRFYDPSNGNLCIDG 1069

  Fly   526 YKLSDISPYWLRSNVLGFIEQQPVLFGTSILENIRYGKPDAGEEDVYAAARLSQSHDFVTALPDG 590
            :.:..::...||.. |..::|:|.||.|||.|||:||..:|.|.::..||:.:.:|:|::.:.:|
plant  1070 HDIKSVNLRSLRKK-LALVQQEPALFSTSIHENIKYGNENASEAEIIEAAKAANAHEFISRMEEG 1133

  Fly   591 YATHVGERGTQLSGGQRQRIAIARALLKNPRILILDEATSALDATSEAEVQKALDTVVQNRTTLV 655
            |.||||::|.||||||:||:|||||:||:|.:|:|||||||||.::|.:||:|||.:::.|||::
plant  1134 YMTHVGDKGVQLSGGQKQRVAIARAVLKDPSVLLLDEATSALDTSAEKQVQEALDKLMKGRTTIL 1198

  Fly   656 IAHRLSTIRNADLIVVLDQGRVVETGKHDELMGKR-GLYFELVRQQE 701
            :||||||||.||.||||.:|:|||.|.|.||:.|. |.|.:|...||
plant  1199 VAHRLSTIRKADTIVVLHKGKVVEKGSHRELVSKSDGFYKKLTSLQE 1245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	211/615 (34%)
		ABC_membrane	137..415	CDD:279056	70/300 (23%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	122/238 (51%)
ABCB14	NP_174122.1	PTZ00265	47..1243	CDD:240339	215/628 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910