DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1824 and ABCB12

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_171754.1	Gene:	ABCB12 / 839282	AraportID:	AT1G02530	Length:	1273	Species:	Arabidopsis thaliana

Alignment Length:	673	Identity:	219/673 - (32%)
Similarity:	355/673 - (52%)	Gaps:	60/673 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 EEDTASEQHFDWK-----------RLWTYLEPHLWELIGAVCAALIVAYINIRIP---NLLGDLV 158
            |.|:.|.:|...|           :|:.:.:.  :::...:|.:|......:.:|   .|.|||:
plant     8 EGDSVSHEHSTSKTDEKAKTVPLYKLFAFADS--FDVFLMICGSLGAIGNGVCLPLMTLLFGDLI 70

  Fly   159 NTLARYANTYVMDPINNSFVKDVSKPASNLLSLYMLQSGFTFMYIYLLSRVGEQMAAKMRQDLFT 223
            ::..:..|       |...|..|||.....:.|.:.:.|..|:.:......||:.|||:|.:...
plant    71 DSFGKNQN-------NKDIVDVVSKVCLKFVYLGLGRLGAAFLQVACWMITGERQAAKIRSNYLK 128

  Fly   224 QIVVQDIAFFD-ENRTGELVNRLTADVQDFKTSFKQFVSQGLRSAAQLIGGSISLFMISPHMAAI 287
            .|:.|||.||| |..|||:|.|::.|....:.:..:.|.:.::..:..:||....|.....:..:
plant   129 TILRQDIGFFDVETNTGEVVGRMSGDTVHIQDAMGEKVGKFIQLVSTFVGGFALAFAKGWLLTLV 193

  Fly   288 ALASVPCVVMFMTYLGKKLRSLSKSSQAQAERATGVCEEALSNIRTVRSSACEYREMQLFEAETN 352
            .|.|:|.:.|....:...:...|...||...:|..|.|:.:.:||||.|...|.:.:..::....
plant   194 MLTSIPFLAMAGAAMALLVTRASSRGQAAYAKAATVVEQTIGSIRTVASFTGEKQAINSYKKYIT 258

  Fly   353 EAAR------LAQKLGYGIAIFQGLTNFFLNTLVLSTLFMGGHLMSTESLSPGALMAFLVASQGV 411
            .|.:      .:..||.|:.|:...:::.|      .::.||.::..:..:.|:::..::.....
plant   259 SAYKSSIQQGFSTGLGLGVMIYVFFSSYAL------AIWFGGKMILEKGYTGGSVINVIIIVVAG 317

  Fly   412 QRSLAQGSILLGTMIRGMSAGSRVFEFLSLQPQVEL--LRGYIIPQERLHGEIRFENVSFAYPMQ 474
            ..||.|.|..:.....|.:|..::||.:..:|.::.  :.|.::..  :.|:|..::|.|:||.:
plant   318 SMSLGQTSPCVTAFAAGQAAAYKMFETIKRKPLIDAYDVNGKVLGD--IRGDIELKDVHFSYPAR 380

  Fly   475 PDHLVLKDFSLTLRPGQTVALVGASGSGKSTIASLVERFYEPSAGNIKLDGYKLSDISPYWLRSN 539
            ||..:...|||.:..|.|.||||.|||||||:.:|:||||:|.||.:.:||..|.:....|:||.
plant   381 PDEEIFDGFSLFIPSGATAALVGESGSGKSTVINLIERFYDPKAGEVLIDGINLKEFQLKWIRSK 445

  Fly   540 VLGFIEQQPVLFGTSILENIRYGKPDAGEEDVYAAARLSQSHDFVTALPDGYATHVGERGTQLSG 604
            : |.:.|:||||.:||:|||.|||.:|..:::..|..|:.:..|:..||.|..|.|||.||||||
plant   446 I-GLVCQEPVLFSSSIMENIAYGKENATLQEIKVATELANAAKFINNLPQGLDTKVGEHGTQLSG 509

  Fly   605 GQRQRIAIARALLKNPRILILDEATSALDATSEAEVQKALDTVVQNRTTLVIAHRLSTIRNADLI 669
            ||:||||||||:||:||:|:|||||||||..||..||:|||.|:.||||:|:||||||:||||:|
plant   510 GQKQRIAIARAILKDPRVLLLDEATSALDTESERVVQEALDRVMVNRTTVVVAHRLSTVRNADMI 574

  Fly   670 VVLDQGRVVETGKHDELM-GKRGLYFELVRQQERRDIQEQVQAVEDVVAVKEQQATATETSTAAT 733
            .|:..|::||.|.|.||: ...|.|.:|:|.||..               |...|..::.::.::
plant   575 AVIHSGKMVEKGSHSELLKDSVGAYSQLIRCQEIN---------------KGHDAKPSDMASGSS 624

  Fly   734 IATA---AETSAATVTVGSSSFG 753
            ...:   .....:.::.|:||||
plant   625 FRNSNLNISREGSVISGGTSSFG 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	206/605 (34%)
		ABC_membrane	137..415	CDD:279056	65/287 (23%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	128/238 (54%)
ABCB12	NP_171754.1	PTZ00265	3..1267	CDD:240339	219/673 (33%)
		ABC_membrane	50..303	CDD:279056	63/265 (24%)
		ABC_MTABC3_MDL1_MDL2	368..606	CDD:213216	128/238 (54%)
		ABC_membrane	709..978	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1027..1267	CDD:213216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910