Protein Alignment CG1824 and Abcb11

DIOPT Version :10

• Sequence 1: NP_572810.1
• Gene: CG1824 / 32208
• FlyBaseID: FBgn0030403
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: NP_113948.1
• Gene: Abcb11 / 83569
• RGDID: 619930
• Length: 1321
• Species: Rattus norvegicus
• Alignment Length: 671
• Identity: 215/671 - (32%)
• Similarity: 342/671 - (50%)
• Gaps: 70/671 - (10%)

  Fly   130 LW-ELIGAVCAALI-VAYINIRIPNLLGDLVNTLARY---------------ANTYVMDPINNSF 177
            :| .|:|.|||.|. :|...|.|  :.|.:.:...:|               .||.|.  ||:||
  Rat    59 IWLMLMGGVCALLHGMAQPGILI--IFGIMTDIFIKYDIERQELEIPGKACVNNTIVW--INSSF 119

  Fly   178 -----------VKDVSKPASNLLSLY------MLQSGFTFMYIYLLSRVGEQMAAKMRQDLFTQI 225
                       :.|:.........:|      :|..|:..:.:::::  |.:...:||:..|.:|
  Rat   120 HQNMTNGTVCGLVDIESEMIKFSGIYAGVGMTVLILGYFQIRLWVIT--GARQIRRMRKIYFRRI 182

  Fly   226 VVQDIAFFDENRTGELVNRLTADVQDFKTSFKQFVSQGLRSAAQLIGGSISLFMISPHMAAIALA 290
            :..:|.:||....|||.:|...|::....:....::..|:..:..:.|.:..|.....:..:.||
  Rat   183 MRMEIGWFDCTSVGELNSRFADDIEKINDAIADQLAHFLQRMSTAMCGLLLGFYRGWKLTLVILA 247

  Fly   291 SVPCVVMFMTYLGKKLRSLSKSSQAQAERATGVCEEALSNIRTVRSSACEYREMQLFEAETNEAA 355
            ..|.:.:....:|..:...::.......:|..:.:|.||:||||.:...|.:|::.:|.....|.
  Rat   248 VSPLIGIGAAVIGLSIAKFTELELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLVFAQ 312

  Fly   356 RLAQKLGYGIAIFQG---LTNFFLNTLVL---STLFMGGHLMSTESLSPGALMAFLVASQGVQRS 414
            |.....|..:..|.|   ...||...|..   |||     ::..|..:||.|:...:.......:
  Rat   313 RWGIWKGMVMGFFTGYMWCLIFFCYALAFWYGSTL-----VLDEEEYTPGTLVQIFLCVILAAMN 372

  Fly   415 LAQGSILLGTMIRGMSAGSRVFEFLSLQPQVELLRGYIIPQERLHGEIRFENVSFAYPMQPDHLV 479
            :...|..|.....|.||.:.:|:.:..||.::.:.|.....:|:.|||.|.||:|.||.:||..:
  Rat   373 IGHASSCLEIFSTGCSAATNIFQTIDRQPVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKI 437

  Fly   480 LKDFSLTLRPGQTVALVGASGSGKSTIASLVERFYEPSAGNIKLDGYKLSDISPYWLRSNVLGFI 544
            |.:.|:.::||:|.||||:||:||||...|::|||:|..|.:.|||:.:..::..|||..: |.:
  Rat   438 LDNLSMVIKPGETTALVGSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQI-GIV 501

  Fly   545 EQQPVLFGTSILENIRYGKPDAGEEDVYAAARLSQSHDFVTALPDGYATHVGERGTQLSGGQRQR 609
            ||:||||.|:|.||||:|:.||..||:..||:.:.:::|:.|||..:.|.|||.|.|:||||:||
  Rat   502 EQEPVLFSTTIAENIRFGREDATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQR 566

  Fly   610 IAIARALLKNPRILILDEATSALDATSEAEVQKALDTVVQNRTTLVIAHRLSTIRNADLIVVLDQ 674
            :||||||::||:||:||.||||||..|||.||:||:.:....|.:.:||||||:|.||:|:..:.
  Rat   567 VAIARALIRNPKILLLDMATSALDNESEARVQEALNKIQHGHTIISVAHRLSTVRAADVIIGFEH 631

  Fly   675 GRVVETGKHDELMGKRGLYFELVRQQERRDIQEQVQAVEDVVAVKEQQATATETSTAATIATAAE 739
            |..||.|.|:||:.::|:||.||..|.:.|...:                  |||.....||...
  Rat   632 GVAVERGTHEELLERKGVYFMLVTLQSQGDNAHK------------------ETSIMGKDATEGG 678

  Fly   740 TSAATVTVGSSSFGGRANAAQ 760
            |...|.:.||.....||:..|
  Rat   679 TLERTFSRGSYRDSLRASIRQ 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..702	CDD:440747	202/611 (33%)
Abcb11	NP_113948.1	PTZ00265	150..1314	CDD:240339	194/576 (34%)
		Interaction with HAX1. /evidence=ECO:0000269|PubMed:15159385	651..674		8/40 (20%)