DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1824 and ABCB2

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_194326.2	Gene:	ABCB2 / 828702	AraportID:	AT4G25960	Length:	1273	Species:	Arabidopsis thaliana

Alignment Length:	702	Identity:	225/702 - (32%)
Similarity:	365/702 - (51%)	Gaps:	91/702 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LPRLQNAARLMRQHLRGTNAPQPPAIPPTNASRLLQTTRLLVWGGGSLAIGLGARSWWAGHRGAI 92
            |.|||..|.|.|.........:|.:|   ..||.|..|                ||.:...|.::
plant   635 LLRLQETASLQRNPSLNRTLSRPHSI---KYSRELSRT----------------RSSFCSERESV 680

  Fly    93 VHCEGSRLAIRKEEEEEDTASEQHFDWKRLWTYLEPH-LWELIGAVCAALIVAYINIRIPNLLGD 156
            ...:|:           |.:.:......||::.:.|. ::.:.|.:||.:    ...::|.....
plant   681 TRPDGA-----------DPSKKVKVTVGRLYSMIRPDWMYGVCGTICAFI----AGSQMPLFALG 730

  Fly   157 LVNTLARYANTYVMDPINNSFVKDVSKPASNLLSLYMLQSGFTFMYIYLLSRV-----GEQMAAK 216
            :...|..|.:.:          .:..|....:..|:...|..| :.:|.:..:     ||::..:
plant   731 VSQALVSYYSGW----------DETQKEIKKIAILFCCASVIT-LIVYTIEHICFGTMGERLTLR 784

  Fly   217 MRQDLFTQIVVQDIAFFDE--NRTGELVNRLTADVQDFKTSFKQFVSQGLRSAAQLIGGSISLFM 279
            :|:::|..|:..:|.:|||  |.:..|.:||.:|....||......:..|::...::...|..|:
plant   785 VRENMFRAILKNEIGWFDEVDNTSSMLASRLESDATLLKTIVVDRSTILLQNLGLVVTSFIIAFI 849

  Fly   280 ISPHMAAIALASVPCVV-------MFMTYLGKKLRSLSKSSQAQAERATGVCEEALSNIRTVRSS 337
            ::..:..:.||:.|.|:       :||...|..|    ..:..:|....|   |::||||||.:.
plant   850 LNWRLTLVVLATYPLVISGHISEKLFMQGYGGDL----NKAYLKANMLAG---ESVSNIRTVAAF 907

  Fly   338 ACEYREMQLFEAETNEAARLAQKLGYGIAIFQGLTNFFLNTLVLSTLFMGGHLMSTESLS--PGA 400
            ..|.:.::|:..|..|.::.:.:.|....:|.|::.||:.:.....|:.|..||. :.|:  ...
plant   908 CAEEKILELYSRELLEPSKSSFRRGQIAGLFYGVSQFFIFSSYGLALWYGSTLMD-KGLAGFKSV 971

  Fly   401 LMAFLVASQGVQRSLAQGS--ILLGTMIRGMSAGSRVFEFLSLQPQV------ELLRGYIIPQER 457
            :..|:|.   :..:||.|.  .|...:::|....:.|||.|..:.|:      ||        ..
plant   972 MKTFMVL---IVTALAMGETLALAPDLLKGNQMVASVFEILDRKTQIVGETSEEL--------NN 1025

  Fly   458 LHGEIRFENVSFAYPMQPDHLVLKDFSLTLRPGQTVALVGASGSGKSTIASLVERFYEPSAGNIK 522
            :.|.|..:.|.|:||.:||.::.:||.|.:|.|:::||||.||||||::.||:.|||:|:||.:.
plant  1026 VEGTIELKGVHFSYPSRPDVVIFRDFDLIVRAGKSMALVGQSGSGKSSVISLILRFYDPTAGKVM 1090

  Fly   523 LDGYKLSDISPYWLRSNVLGFIEQQPVLFGTSILENIRYGKPDAGEEDVYAAARLSQSHDFVTAL 587
            ::|..:..:....||.:: |.::|:|.||.|:|.|||.||...|.:.:|..:|.|:.:|.|:|:|
plant  1091 IEGKDIKKLDLKALRKHI-GLVQQEPALFATTIYENILYGNEGASQSEVVESAMLANAHSFITSL 1154

  Fly   588 PDGYATHVGERGTQLSGGQRQRIAIARALLKNPRILILDEATSALDATSEAEVQKALDTVVQNRT 652
            |:||:|.|||||.|:|||||||||||||:||||.||:|||||||||..||..||:|||.::.|||
plant  1155 PEGYSTKVGERGVQMSGGQRQRIAIARAILKNPAILLLDEATSALDVESERVVQQALDRLMANRT 1219

  Fly   653 TLVIAHRLSTIRNADLIVVLDQGRVVETGKHDEL-MGKRGLYFELVRQQERR 703
            |:|:|||||||:|||.|.||..|::||.|.|.:| :.|.|.||:|:..|:::
plant  1220 TVVVAHRLSTIKNADTISVLHGGKIVEQGSHRKLVLNKSGPYFKLISLQQQQ 1271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	206/607 (34%)
		ABC_membrane	137..415	CDD:279056	62/293 (21%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	127/238 (53%)
ABCB2	NP_194326.2	PTZ00265	76..1269	CDD:240339	224/698 (32%)
		ABC_membrane	86..349	CDD:279056
		ABC_MTABC3_MDL1_MDL2	401..639	CDD:213216	2/3 (67%)
		ABC_membrane	714..983	CDD:279056	62/294 (21%)
		ABC_MTABC3_MDL1_MDL2	1030..1268	CDD:213216	127/238 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910