DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1824 and TAP2

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_000535.3	Gene:	TAP2 / 6891	HGNCID:	44	Length:	703	Species:	Homo sapiens

Alignment Length:	673	Identity:	207/673 - (30%)
Similarity:	339/673 - (50%)	Gaps:	64/673 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 IPPTNASRLLQTTRLLVWGGGS-------------LAIGLGAR--SW--WAGHRGAIVHCEGSRL 100
            :|...|:.|..:.|.||.|...             |.:|.||.  ||  |     |::...|:
Human    67 LPLCLATPLTVSLRALVAGASRAPPARVASAPWSWLLVGYGAAGLSWSLW-----AVLSPPGA-- 124

  Fly   101 AIRKEEEEEDTASEQHFDWKRLWTYLEPHLWELIGAVCAALIVAYINIRIPNLLGDLVNTLARYA 165
                :|:|:|..:.:...| ||.....|.|         .|:||.....:..:||:   ||..:.
Human   125 ----QEKEQDQVNNKVLMW-RLLKLSRPDL---------PLLVAAFFFLVLAVLGE---TLIPHY 172

  Fly   166 NTYVMDPINNSFVKDVSKPASNLLSLYMLQSGFTF-----MYIYLLSRVGEQMAAKMRQDLFTQI 225
            :..|:|.:...|.......|...:.|:...|..:.     .:.|.:||:.    .::|:.||:.:
Human   173 SGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRIN----LRIREQLFSSL 233

  Fly   226 VVQDIAFFDENRTGELVNRLTADVQDFKTSFKQFVSQGLRSAAQLIGGSISLFMISPHMAAIALA 290
            :.||:.||.|.:||||.:||::|............:..|||..:::|....:..|||.:..::|.
Human   234 LRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLL 298

  Fly   291 SVPCVVMFMTYLGKKLRSLSKSSQAQAERATGVCEEALSNIRTVRSSACEYREMQLFEAETNEAA 355
            .:|..:........:.:.:.:..|....||..|..||:..::||||...|..|:..::....:..
Human   299 HMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCR 363

  Fly   356 RLAQKLGYGIAIF---QGLTNFFLNTLVLSTLFMGGHLMSTESLSPGALMAFLVASQGVQRSLAQ 417
            :|..:.....|::   :.:.:..:..|:||   .|...|....|:.|:|::|::..:.|...:..
Human   364 QLYWRRDLERALYLLVRRVLHLGVQMLMLS---CGLQQMQDGELTQGSLLSFMIYQESVGSYVQT 425

  Fly   418 GSILLGTMIRGMSAGSRVFEFLSLQPQVELLRGYIIPQERLHGEIRFENVSFAYPMQPDHLVLKD 482
            ...:.|.|:..:.|..:||.::..||.:. ..|.:.| ..|.|.::|::||||||.:||..|||.
Human   426 LVYIYGDMLSNVGAAEKVFSYMDRQPNLP-SPGTLAP-TTLQGVVKFQDVSFAYPNRPDRPVLKG 488

  Fly   483 FSLTLRPGQTVALVGASGSGKSTIASLVERFYEPSAGNIKLDGYKLSDISPYWLRSNVLGFIEQQ 547
            .:.|||||:..||||.:||||||:|:|::..|:|:.|.:.||...:|.....:|.|.|:. :.|:
Human   489 LTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVS-VGQE 552

  Fly   548 PVLFGTSILENIRYGKPDAGEEDVYAAARLSQSHDFVTALPDGYATHVGERGTQLSGGQRQRIAI 612
            ||||..|:..||.||.....::.|.|||:.:.:.||:..:..|..|.|||:|:||:.||:||:||
Human   553 PVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAI 617

  Fly   613 ARALLKNPRILILDEATSALDATSEAEVQKALDTVVQNRTTLVIAHRLSTIRNADLIVVLDQGRV 677
            ||||:::||:|||||||||||...|..:|.....  .:||.|||||||..::.|..|:||.:|::
Human   618 ARALVRDPRVLILDEATSALDVQCEQALQDWNSR--GDRTVLVIAHRLQAVQRAHQILVLQEGKL 680

  Fly   678 VETGKHDELMGKRGLYFELVRQQ 700
               .|..:|...:.||..||:|:
Human   681 ---QKLAQLQEGQDLYSRLVQQR 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	188/590 (32%)
		ABC_membrane	137..415	CDD:279056	64/285 (22%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	107/237 (45%)
TAP2	NP_000535.3	3a01208	1..697	CDD:273363	204/668 (31%)
		Part of the peptide-binding site. /evidence=ECO:0000269\|PubMed:8955196	301..389		15/87 (17%)
		Part of the peptide-binding site. /evidence=ECO:0000269\|PubMed:8955196	414..433		2/18 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D684058at2759
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920