DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1824 and TAP1

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_000584.3	Gene:	TAP1 / 6890	HGNCID:	43	Length:	748	Species:	Homo sapiens

Alignment Length:	774	Identity:	235/774 - (30%)
Similarity:	370/774 - (47%)	Gaps:	165/774 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 IFSRHLLQPTQQPLPRL------------QNAARLMRQHL---------RGTNAPQPP------- 51
            |||  ||.||..||.|:            ..|..::|..:         :|..|...|
Human    43 IFS--LLVPTALPLLRVWAVGLSRWAVLWLGACGVLRATVGSKSENAGAQGWLAALKPLAAALGL 105

  Fly    52 AIPPTNASRLL---------QTTRLLVWGGG------SLAIGLGARSWW---------AGHRGA- 91
            |:|.....|.|         .:||||.||..      |.|..|.|.:.|         .|..|:
Human   106 ALPGLALFRELISWGAPGSADSTRLLHWGSHPTAFVVSYAAALPAAALWHKLGSLWVPGGQGGSG 170

  Fly    92 -----IVHCEGSRLAIRKEEEEEDTASEQHFDWKRLWTYLEPHLWELIGAVCAALIVAYINIRIP 151
                 ::.|.||                   :.:||..:|...:...:|           .:.||
Human   171 NPVRRLLGCLGS-------------------ETRRLSLFLVLVVLSSLG-----------EMAIP 205

  Fly   152 NLLGDLVNTLARYANTYVMDPINNSFVKDVSKPASNLLSLYMLQSGFTFMYIYLLSRVGE----- 211
            ...|.|.:.:       :.|...::|.::::     |:|:..:.|.       :|..||:
Human   206 FFTGRLTDWI-------LQDGSADTFTRNLT-----LMSILTIASA-------VLEFVGDGIYNN 251

  Fly   212 ---QMAAKMRQDLFTQIVVQDIAFFDENRTGELVNRLTADVQDFKTS-------FKQFVSQGLRS 266
               .:.:.::.::|..::.|:..||.:|:||.:::|:|.|......|       |..::.:||..
Human   252 TMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCL 316

  Fly   267 AAQLIGGSISLFMISPHMAAIALASVPCVVMFMTYLGK-------KLR-SLSKSSQAQAERATGV 323
            ...::.||:||.|::       |.::|.:.:....:||       ::| ||:||||        |
Human   317 LGIMLWGSVSLTMVT-------LITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQ--------V 366

  Fly   324 CEEALSNIRTVRSSACEYREMQLFEAETNEAARLAQKLGYGIAIFQGLTNFFLNTLVLSTLFMGG 388
            ..||||.:.||||.|.|..|.|.|..:..|...|.||.....|:....|:.....|.:..|::||
Human   367 AIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGG 431

  Fly   389 HLMSTESLSPGALMAFLVASQGVQRSLAQG-SILLGTMIR---GMSAGSRVFEFLSLQPQVELLR 449
            .|:::.::|.|.|:.|::    .|....|. .:||....|   .:.:..::||:|...|:.. ..
Human   432 QLVTSGAVSSGNLVTFVL----YQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCP-PS 491

  Fly   450 GYIIPQERLHGEIRFENVSFAYPMQPDHLVLKDFSLTLRPGQTVALVGASGSGKSTIASLVERFY 514
            |.:.|. .|.|.::|::||||||.:||.|||:..:.|||||:..||||.:||||||:|:|::..|
Human   492 GLLTPL-HLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLY 555

  Fly   515 EPSAGNIKLDGYKLSDISPYWLRSNVLGFIEQQPVLFGTSILENIRYG---KPDAGEEDVYAAAR 576
            :|:.|.:.|||..|......:|...|.. :.|:|.:||.|:.|||.||   ||..  |::.|||.
Human   556 QPTGGQLLLDGKPLPQYEHRYLHRQVAA-VGQEPQVFGRSLQENIAYGLTQKPTM--EEITAAAV 617

  Fly   577 LSQSHDFVTALPDGYATHVGERGTQLSGGQRQRIAIARALLKNPRILILDEATSALDATSEAEVQ 641
            .|.:|.|::.||.||.|.|.|.|:||||||||.:|:||||::.|.:||||:|||||||.|:.:|:
Human   618 KSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVE 682

  Fly   642 KALDTVVQ--NRTTLVIAHRLSTIRNADLIVVLDQGRVVETGKHDELMGKRGLYFELVR 698
            :.|....:  :|:.|:|...||.:..||.|:.|:.|.:.|.|.|.:||.|:|.|:.:|:
Human   683 QLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQ 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	200/612 (33%)
		ABC_membrane	137..415	CDD:279056	72/300 (24%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	112/242 (46%)
TAP1	NP_000584.3	3a01208	18..740	CDD:273363	234/771 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0058
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D684058at2759
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820