DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1824 and abcb9

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_001119906.1	Gene:	abcb9 / 570148	ZFINID:	ZDB-GENE-050517-12	Length:	789	Species:	Danio rerio

Alignment Length:	667	Identity:	234/667 - (35%)
Similarity:	354/667 - (53%)	Gaps:	70/667 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LLVWGGGSLAIGLGARSWW---AGHRGAIVHCEGSRLAIRKEEEEEDTASEQHFDWK-------- 120
            |..|   :....:|...:|   :....|:...|.|....|..:|.||.:.:.....|
Zfish   119 LFSW---TCVAAIGVMIFWKILSQTPNAVSDREDSEDTERLVDETEDESEKSMKSGKEHTHSGAT 180

  Fly   121 --RLWTYLE--------PHLWELIGAVCAALIVAYINIRIPNLLGDLVNTLARYANTYVMDPINN 175
              ||.:|.:        ...:.|:.|||.|.|..|....|..::  :..::..:|
Zfish   181 IGRLLSYCKKDSSLLSIAFFFLLLSAVCEAFIPYYTGQAIDGIV--IQKSMDHFA---------- 233

  Fly   176 SFVKDVSKPASNLLSLYMLQS---GF-------TFMYIYLLSRVGEQMAAKMRQDLFTQIVVQDI 230
                   ||...|..|.::.|   ||       ||          .::..::|..||..::.|:|
Zfish   234 -------KPMITLSVLALVSSIAIGFRGGVFSVTF----------ARLNIRLRNLLFRSLMHQEI 281

  Fly   231 AFFDENRTGELVNRLTADVQDFKTSFKQFVSQGLRSAAQLIGGSISLFMISPHMAAIALASVPCV 295
            .|||.|.||::.:|||:|.........|.|:..|||..:.:|..|.:|.:|..::.:.:...|.:
Zfish   282 GFFDANHTGDITSRLTSDTTQVSDLISQNVNLFLRSFVKAVGIFIFMFGMSWKLSVVTIMGFPYI 346

  Fly   296 VMFMTYLGKKLRSLSKSSQAQAERATGVCEEALSNIRTVRSSACEYREMQLFEAETNEAARLAQK 360
            .:.....|:..:.|:|..|....:|..|.||.:|.:|||||.|.|.:|..::.:...|...|.:|
Zfish   347 AVVSKLYGEYYKKLTKEVQTALAQANKVAEETISAMRTVRSFANEDQEGDMYYSRLQEMFVLNKK 411

  Fly   361 LGYGIAIFQGLTNFFLNTLVL--STLFMGGHLMSTESLSPGALMAFLVASQGVQRSLAQGSILLG 423
            .....|.|  :.:.:::.|.|  :.||.||||:.|..:|.|.|::|::....:..:|...|.:..
Zfish   412 QAIAYACF--MWSSYISELALQVAILFYGGHLVVTNQMSGGTLISFVIYELELGEALESISSVYT 474

  Fly   424 TMIRGMSAGSRVFEFLSLQPQVELLRGYIIPQERLHGEIRFENVSFAYPMQPDHLVLKDFSLTLR 488
            .:::|:.|..:|||::..:|: ..|.|...| |.|.|::.|.||:||||.:|:..|||:.|.:||
Zfish   475 GLMQGVGAAEKVFEYIDRKPK-HALNGQEAP-ETLEGQVEFNNVTFAYPSRPEMDVLKNVSFSLR 537

  Fly   489 PGQTVALVGASGSGKSTIASLVERFYEPSAGNIKLDGYKLSDISPYWLRSNVLGFIEQQPVLFGT 553
            |||..||||.||.|||:...|:|.||.|..|.:.:||..::.....:..|.| ..:.|:||||..
Zfish   538 PGQVTALVGPSGGGKSSCVCLLENFYAPQQGQVLVDGRPVNTYQHKYYHSKV-ALVAQEPVLFAR 601

  Fly   554 SILENIRYGKPDAGEEDVYAAARLSQSHDFVTALPDGYATHVGERGTQLSGGQRQRIAIARALLK 618
            ::..||.||.|:|..|.|..||..:.:|||:|.|..||.:.|||:||||||||:||:||||||::
Zfish   602 TVQMNISYGVPEAPMEAVIRAAINANAHDFITGLSKGYDSGVGEKGTQLSGGQKQRVAIARALIR 666

  Fly   619 NPRILILDEATSALDATSEAEVQKALDTVVQNRTTLVIAHRLSTIRNADLIVVLDQGRVVETGKH 683
            :||||||||||||||:.||..||:||:.:::..|.|||||||||:..||.|:|:|:|.|||.|.|
Zfish   667 SPRILILDEATSALDSESEYIVQQALNNLMREHTVLVIAHRLSTVERADNILVIDKGSVVEQGPH 731

  Fly   684 DELMGKRGLYFELVRQQ 700
            .|||.:.|||.:||::|
Zfish   732 AELMARGGLYCKLVQRQ 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	223/612 (36%)
		ABC_membrane	137..415	CDD:279056	76/289 (26%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	126/237 (53%)
abcb9	NP_001119906.1	3a01208	46..745	CDD:273363	231/662 (35%)
		ABC_membrane	199..458	CDD:279056	78/289 (27%)
		P-loop_NTPase	500..725	CDD:304359	118/226 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0058
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54509
OrthoDB	1	1.010	-	-		D684058at2759
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.730