Protein Alignment CG1824 and ABCB4

DIOPT Version :10

• Sequence 1: NP_572810.1
• Gene: CG1824 / 32208
• FlyBaseID: FBgn0030403
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: XP_054214377.1
• Gene: ABCB4 / 5244
• HGNCID: 45
• Length: 1384
• Species: Homo sapiens
• Alignment Length: 765
• Identity: 230/765 - (30%)
• Similarity: 355/765 - (46%)
• Gaps: 131/765 - (17%)

  Fly    41 HLRGTNAPQPPAIPPTNASRLL--------------------------QTTRLLVWGGGSLAIGL 79
            ||:|...|.......|..|.|:                          ::.||..|...||...|
Human     6 HLQGLGWPIRRGFLGTRGSSLISVLSCDRAGSGGSPGWAAAPAGRPGGKSGRLRPWPAPSLGREL 70

  Fly    80 GARSWWAGHRGAI---------------------VHCEGS-RLAIRKEEEEEDTASE-------- 114
            |.|........|:                     ...||. .|.|..:::.:.|.:.
Human    71 GGRRELLSRAAALALAATAEMDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTL 135

  Fly   115 -QHFDWKRLWTYLEPHLWELIGAVCAALIVAYINIRIPNLL---GDLVNTLARYANTYVMDPINN 175
             ::.||       :..|:..:|.:.|   :|: ...:|.::   |::.:.....|..:.. |:|
Human   136 FRYSDW-------QDKLFMSLGTIMA---IAH-GSGLPLMMIVFGEMTDKFVDTAGNFSF-PVN- 187

  Fly   176 SFVKDVSKPASNLLSLYMLQSGFTFMYIYLLSRVGE-------------QMAA-----KMRQDLF 222
             |...:..|..      :|:...| .|.|..|.:|.             .:||     |:||..|
Human   188 -FSLSLLNPGK------ILEEEMT-RYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFF 244

  Fly   223 TQIVVQDIAFFDENRTGELVNRLTADVQDFKTSFKQFVSQGLRSAAQLIGGSISLFMISPHMAAI 287
            ..|:.|:|.:||.|.|.||..|||.|:..........|....::.|....|.|..|:....:..:
Human   245 HAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLV 309

  Fly   288 ALASVPCVVMFMTYLGKKLRSLSKSSQAQAERATGVCEEALSNIRTVRSSACEYREMQLFEAETN 352
            .:|..|.:.:......|.|.:.|....|...:|..|.||||..||||.:...:.:|::.::....
Human   310 IMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLE 374

  Fly   353 EAARLAQK------LGYGIAIF-----QGLTNFFLNTLVLSTLFMGGHLMST-ESLSPGALMAFL 405
            .|..:..|      :..|||..     ..|..::.:|||:|..:..|:.|:. .|:..||.
Human   375 NAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAF---- 435

  Fly   406 VASQGVQRSLAQGSILLGTMIRGMSAGSRVFEFLSLQPQVELL--RGYIIPQERLHGEIRFENVS 468
                    |:.|.:..:........|...:|:.:...|:::..  ||:  ..:.:.|.:.|.:|.
Human   436 --------SVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGH--KPDSIKGNLEFNDVH 490

  Fly   469 FAYPMQPDHLVLKDFSLTLRPGQTVALVGASGSGKSTIASLVERFYEPSAGNIKLDGYKLSDISP 533
            |:||.:.:..:||..:|.::.||||||||:||.||||...|::|.|:|..|.|.:||..:.:.:.
Human   491 FSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNV 555

  Fly   534 YWLRSNVLGFIEQQPVLFGTSILENIRYGKPDAGEEDVYAAARLSQSHDFVTALPDGYATHVGER 598
            .:|| .::|.:.|:||||.|:|.|||.||:.:...:::..|.:.:.:::|:..||..:.|.||||
Human   556 NYLR-EIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGER 619

  Fly   599 GTQLSGGQRQRIAIARALLKNPRILILDEATSALDATSEAEVQKALDTVVQNRTTLVIAHRLSTI 663
            |.||||||:|||||||||::||:||:|||||||||..||||||.|||...:.|||:||||||||:
Human   620 GAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTV 684

  Fly   664 RNADLIVVLDQGRVVETGKHDELMGKRGLYFELVRQQERRDIQEQVQAVE 713
            ||||:|...:.|.:||.|.|.|||.|.|:||:||..|..   ..|:|:.|
Human   685 RNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTS---GSQIQSEE 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..702	CDD:440747	205/617 (33%)
ABCB4	XP_054214377.1	PTZ00265	108..1369	CDD:240339	214/663 (32%)