Protein Alignment CG1824 and ABCB1

DIOPT Version :10

• Sequence 1: NP_572810.1
• Gene: CG1824 / 32208
• FlyBaseID: FBgn0030403
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: NP_001335874.1
• Gene: ABCB1 / 5243
• HGNCID: 40
• Length: 1350
• Species: Homo sapiens
• Alignment Length: 738
• Identity: 231/738 - (31%)
• Similarity: 355/738 - (48%)
• Gaps: 104/738 - (14%)

  Fly    59 SRLLQTTRLLVWGGGSLAIG--------------LGARSWWAGHRGAIVHCEGSR---------- 99
            |:.|:.:.....|.|::..|              ||.||   ..|...:..||.|
Human    26 SQFLEESAFSQSGPGAVICGLSTKVGVSSSKISRLGGRS---KEREVGMDLEGDRNGGAKKKNFF 87

  Fly   100 ----LAIRKEEEEEDTASEQHFDWKRLWTYLEPHLWELIGAVCAALIVAYINIRIPNLLGDLVNT 160
                .:.:.::|::.|.|.  |...|...:|: .|:.::|.:.|.:..|.:.:.: .:.|::.:.
Human    88 KLNNKSEKDKKEKKPTVSV--FSMFRYSNWLD-KLYMVVGTLAAIIHGAGLPLMM-LVFGEMTDI 148

  Fly   161 LARYANTY-VMDPINNSFVKDVSKPASNLLSLYM-LQSGFTFMYIYLLSRVGEQ----------- 212
            .|...|.. :|..|.|.  .|:     |....:| |:...| .|.|..|.:|..
Human   149 FANAGNLEDLMSNITNR--SDI-----NDTGFFMNLEEDMT-RYAYYYSGIGAGVLVAAYIQVSF 205

  Fly   213 --MAA-----KMRQDLFTQIVVQDIAFFDENRTGELVNRLTADVQDFKTSFKQFVSQGLRSAAQL 270
              :||     |:|:..|..|:.|:|.:||.:..|||..|||.||..........:....:|.|..
Human   206 WCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATF 270

  Fly   271 IGGSISLFMISPHMAAIALASVPCVVMFMTYLGKKLRSLSKSSQAQAERATGVCEEALSNIRTVR 335
            ..|.|..|.....:..:.||..|.:.:......|.|.|.:........:|..|.||.|:.||||.
Human   271 FTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVI 335

  Fly   336 SSACEYREMQLFEAETNEAARLAQK-----------------LGYGIAIFQGLTNFFLNTLVLST 383
            :...:.:|::.:.....||.|:..|                 ..|.:|.:.|      .|||||.
Human   336 AFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYG------TTLVLSG 394

  Fly   384 LFMGGHLMST-ESLSPGALMAFLVASQGVQRSLAQGSILLGTMIRGMSAGSRVFEFLSLQPQVEL 447
            .:..|.:::. .|:..||.            |:.|.|..:........|...:|:.:..:|.::.
Human   395 EYSIGQVLTVFFSVLIGAF------------SVGQASPSIEAFANARGAAYEIFKIIDNKPSIDS 447

  Fly   448 LRGYIIPQERLHGEIRFENVSFAYPMQPDHLVLKDFSLTLRPGQTVALVGASGSGKSTIASLVER 512
            ........:.:.|.:.|.||.|:||.:.:..:||..:|.::.||||||||.||.||||...|::|
Human   448 YSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQR 512

  Fly   513 FYEPSAGNIKLDGYKLSDISPYWLRSNVLGFIEQQPVLFGTSILENIRYGKPDAGEEDVYAAARL 577
            .|:|:.|.:.:||..:..|:..:|| .::|.:.|:||||.|:|.||||||:.:...:::..|.:.
Human   513 LYDPTEGMVSVDGQDIRTINVRFLR-EIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKE 576

  Fly   578 SQSHDFVTALPDGYATHVGERGTQLSGGQRQRIAIARALLKNPRILILDEATSALDATSEAEVQK 642
            :.::||:..||..:.|.|||||.||||||:|||||||||::||:||:|||||||||..|||.||.
Human   577 ANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQV 641

  Fly   643 ALDTVVQNRTTLVIAHRLSTIRNADLIVVLDQGRVVETGKHDELMGKRGLYFELVRQQERRDIQE 707
            |||...:.|||:||||||||:||||:|...|.|.:||.|.|||||.::|:||:||..|...:..|
Human   642 ALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVE 706

  Fly   708 QVQAVEDVVAVKEQQATATETST 730
            ...|.::    .:.:..|.|.|:
Human   707 LENAADE----SKSEIDALEMSS 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..702	CDD:440747	209/620 (34%)
ABCB1	NP_001335874.1	PTZ00265	123..1337	CDD:240339	211/635 (33%)