DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1824 and tap2a

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_001006594.1	Gene:	tap2a / 368771	ZFINID:	ZDB-GENE-030616-245	Length:	725	Species:	Danio rerio

Alignment Length:	712	Identity:	229/712 - (32%)
Similarity:	345/712 - (48%)	Gaps:	96/712 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LVWGGGSLAIGLG---ARSWWAGHRGAIVHC------EGSRLAIRKEEEEEDTASEQHFDWKRLW 123
            |::.|.:|:....   .|.|      ..|||      |..|||:              |:..||.
Zfish    52 LLYAGSTLSKDAADPLIRRW------ITVHCFIGSVYETGRLAM--------------FNNYRLD 96

  Fly   124 TYLEPHLWELIGAVCAALIVAYINIRIPNLLGD-------------LVNTLARYANTY------- 168
            .:.   :| |:|.|.|||...:..|.:|:...:             .:..:..|...|
Zfish    97 KFT---VW-LVGTVAAALACLFWEITLPDTNEESNGKERKQKARVLFIRVIRLYRPDYILLFGAF 157

  Fly   169 -------------------VMDPINNSFVKDVSKPASNLLSLYMLQSGFT-------FMYIYLLS 207
                               |:|.:.:.:..|..:.|...:.|:.|.|.|:       ||...
Zfish   158 VFLALAVLCEMFIPLYTGEVIDILGSHYQWDNFRSAIIFMGLFSLGSSFSAGCRGGLFMCAI--- 219

  Fly   208 RVGEQMAAKMRQDLFTQIVVQDIAFFDENRTGELVNRLTADVQDFKTSFKQFVSQGLRSAAQLIG 272
               .....:::..||..::.|||.||:..:||::.:||:.|......:....|:..||:..:.:|
Zfish   220 ---NSFTCRVKVQLFGSLIRQDIGFFETIKTGDITSRLSTDTTLMGRAVALNVNVLLRTLVKTLG 281

  Fly   273 GSISLFMISPHMAAIALASVPCVVMFMTYLGKKLRSLSK---SSQAQAERATGVCEEALSNIRTV 334
            ....:..:|..:..:.|...|...:.........:.|||   .|.|||..|.|   ||:|.||||
Zfish   282 MLYLMVSLSWKLTLLMLMETPLTGLLQNIYDTHYQKLSKEVQDSMAQANDAAG---EAVSGIRTV 343

  Fly   335 RSSACEYREMQLFEAETNEAARLAQKLGYGIAIFQGLTNFFLNTLVLSTLFMGGHLMSTESLSPG 399
            :|...|..|...::....|...|..:.....||:..:.......:.::.|:.|...:....:|.|
Zfish   344 KSFKTELGEAHRYDGRLMETHNLKTRRDTVRAIYLLIRRMTELGMKVAMLYYGRLFIQYGQMSTG 408

  Fly   400 ALMAFLVASQGVQRSLAQGSILLGTMIRGMSAGSRVFEFLSLQPQVELLRGYIIPQERLHGEIRF 464
            .|::|::..|.:..::.....:.|.|:..:.|..:|||:...:.:|. :.|.::|:: |.|.::|
Zfish   409 NLVSFILYQQDLGDNIRTLIYIFGDMLNSVGAAGKVFEYQDRKSEVS-IDGNLMPKD-LKGHVKF 471

  Fly   465 ENVSFAYPMQPDHLVLKDFSLTLRPGQTVALVGASGSGKSTIASLVERFYEPSAGNIKLDGYKLS 529
            :.::|:||.:|||.|||||||.|:|||..||||.||.||||..||:||||:|..|.|.|||..|.
Zfish   472 QKLTFSYPRRPDHNVLKDFSLELKPGQITALVGMSGGGKSTCVSLLERFYQPQQGTILLDGKPLQ 536

  Fly   530 DISPYWLRSNVLGFIEQQPVLFGTSILENIRYGKPDAGEEDVYAAARLSQSHDFVTALPDGYATH 594
            |....:|.|.| ..:.|:||||..::.:||.||......|.|..||..:.:|.|::.|..||.|.
Zfish   537 DYQHKYLHSKV-AMVGQEPVLFSGTVRDNIAYGLQGCSMERVKEAASKANAHSFISKLEKGYDTD 600

  Fly   595 VGERGTQLSGGQRQRIAIARALLKNPRILILDEATSALDATSEAEVQKALDTVVQNRTTLVIAHR 659
            |||||..||||::|||||||||::.|::|||||.||:||..||..||:|| :....:|.||||||
Zfish   601 VGERGNLLSGGEKQRIAIARALIREPQVLILDEVTSSLDTESEQMVQQAL-SCCPTQTLLVIAHR 664

  Fly   660 LSTIRNADLIVVLDQGRVVETGKHDELMGKRGLYFELVRQQERRDIQEQVQAVEDVVAVKEQ 721
            |.||..||.|||:|.|.:||.|.|:|||.|:|.|::| |::...|.:...|..|....||.|
Zfish   665 LKTIERADQIVVIDSGELVEKGTHEELMEKKGSYYKL-RERLFSDDKTTKQEKEKSDTVKTQ 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	210/630 (33%)
		ABC_membrane	137..415	CDD:279056	67/326 (21%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	127/237 (54%)
tap2a	NP_001006594.1	MdlB	136..708	CDD:224055	199/585 (34%)
		ABC_membrane	157..417	CDD:279056	58/268 (22%)
		ABCC_TAP	458..682	CDD:213215	119/226 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0058
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D684058at2759
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820