DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1824 and Mdr49

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster

Alignment Length:	688	Identity:	229/688 - (33%)
Similarity:	339/688 - (49%)	Gaps:	82/688 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 IRKEEEE---------------EDTASEQHFDWKRLWTYLEPHLW--ELIGAVCAALIVAYINI- 148
            ::|||..               :.|....:||..|..|..|..|.  .|:.|..|:..:.|..|
  Fly     2 VKKEESRLPQAGDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMII 66

  Fly   149 --RIPNLLGD----------------------LVNTLARYANTYVMDPIN----NSFVKDVSKPA 185
              ...:||.|                      |.|......|..::|...    .|.|..|
  Fly    67 YGEFTSLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSV---- 127

  Fly   186 SNLLSLYMLQSGFTFMYIYLLSRVGEQMAAKMRQDLFTQIVVQDIAFFDENRTGELVNRLTADVQ 250
                ::::|.:    :.|.|.:|:......::|:.....::.||||::|.:......:::|.|:.
  Fly   128 ----AMFLLIT----LAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLD 184

  Fly   251 DFKTSFKQFVSQGLRSAAQLIGGSISLFMISPHMAAIALASVPCVVMFMTYLGKKLRSLSKSSQA 315
            ..|....:.:...:......:.|.:|.|:....:..:.|:.||.::...:.:.:...||::....
  Fly   185 KLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELK 249

  Fly   316 QAERATGVCEEALSNIRTVRSSACEYREMQLFEAETNEAARLAQKLGYGIAIFQGLTNFFLNTLV 380
            ....|..|.||..|.||||.:.:.:.:|.:.|......|....:|.|    ::.|:.| .|:.|:
  Fly   250 SYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKG----LYSGMGN-ALSWLI 309

  Fly   381 L-----------STLFMGGHLMSTESLSPGALMAFLVASQGVQRSLAQGSILLGTMIRGMSAGSR 434
            :           .||.:....:.....:|..|:..|.|.....::|...|..:..:....:||..
  Fly   310 IYLCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQT 374

  Fly   435 VFEFLSLQPQVELLRGYIIPQERLHGEIRFENVSFAYPMQPDHLVLKDFSLTLRPGQTVALVGAS 499
            :|..:....||:.:.......|...|.||||.:.|.||.:||..:||..::.:.||||||.||||
  Fly   375 LFNIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGAS 439

  Fly   500 GSGKSTIASLVERFYEPSAGNIKLDGYKLSDISPYWLRSNVLGFIEQQPVLFGTSILENIRYGKP 564
            |.||||:..|::|||:|.||::||||..|..::..||||.: |.:.|:||||.|:|.||||||:|
  Fly   440 GCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQI-GVVGQEPVLFATTIGENIRYGRP 503

  Fly   565 DAGEEDVYAAARLSQSHDFVTALPDGYATHVGERGTQLSGGQRQRIAIARALLKNPRILILDEAT 629
            .|.:.|:..|||.:..|||:|.||.||.|.|||:|.|:||||:|||||||||::.|::|:|||||
  Fly   504 SATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEAT 568

  Fly   630 SALDATSEAEVQKALDTVVQNRTTLVIAHRLSTIRNADLIVVLDQGRVVETGKHDELMGKRGLYF 694
            ||||.|||..||.||:...|..||||:|||||||.|||.||.|..|.|.|.|.|:|||.:||||.
  Fly   569 SALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYC 633

  Fly   695 ELVRQQERRDIQEQVQAVEDVVA----VKEQQATATET 728
            |||...:|:   |..:|.|..||    .|.|..:..||
  Fly   634 ELVSITQRK---EATEADEGAVAGRPLQKSQNLSDEET 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	213/623 (34%)
		ABC_membrane	137..415	CDD:279056	58/317 (18%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	140/237 (59%)
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	213/623 (34%)
		ABC_membrane	116..352	CDD:279056	48/252 (19%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	138/234 (59%)
		MdlB	735..1299	CDD:224055
		ABC_membrane	739..998	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I220
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm51436
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	P	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.910