Protein Alignment CG1824 and ABCB5

DIOPT Version :10

• Sequence 1: NP_572810.1
• Gene: CG1824 / 32208
• FlyBaseID: FBgn0030403
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: NP_001157413.1
• Gene: ABCB5 / 340273
• HGNCID: 46
• Length: 1257
• Species: Homo sapiens
• Alignment Length: 653
• Identity: 215/653 - (32%)
• Similarity: 336/653 - (51%)
• Gaps: 69/653 - (10%)

  Fly   130 LWELIGAVCAALIVAYINIRIPNLL-GDLVNT-LARYAN-TYVMDPINNSFVKDVSKPASNLLSL 191
            |..|:...|..|:...:.....||: |.||.| ...|.| |...:.:|...         .||:|
Human    53 LASLVNGACLPLMPLVLGEMSDNLISGCLVQTNTTNYQNCTQSQEKLNEDM---------TLLTL 108

  Fly   192 YMLQSG-----FTFMYIYLLSRVGEQMAAKMRQDLFTQIVVQDIAFFDENRTGELVNRLTADVQD 251
            |.:..|     |.::.|.|......:...::|:..|..::.|||.:||....|||..|:|.|:..
Human   109 YYVGIGVAALIFGYIQISLWIITAARQTKRIRKQFFHSVLAQDIGWFDSCDIGELNTRMTDDIDK 173

  Fly   252 FKTSFKQFVSQGLRSAAQLIGGSISLFMISP--------HMAAIALASVPCVVMFMTYLGKKLRS 308
                    :|.|:.....|:..::|.|.|..        .:..:.|::.|.::.......:.:.|
Human   174 --------ISDGIGDKIALLFQNMSTFSIGLAVGLVKGWKLTLVTLSTSPLIMASAAACSRMVIS 230

  Fly   309 LSKSSQAQAERATGVCEEALSNIRTVRSSACEYREMQLFEAETNEAARLAQKLGYGIAIFQGLTN 373
            |:....:...:|..|.||.||:||||.:...:.:|:|.:.....:|.....|......:..|...
Human   231 LTSKELSAYSKAGAVAEEVLSSIRTVIAFRAQEKELQRYTQNLKDAKDFGIKRTIASKVSLGAVY 295

  Fly   374 FFLN-TLVLSTLFMGGHLMSTESLSPGALMAFLVASQGVQRSLAQGSILLGTMI---------RG 428
            ||:| |..|:..:....:::.|   ||..:..::|   |..|:...|..:|..:         ||
Human   296 FFMNGTYGLAFWYGTSLILNGE---PGYTIGTVLA---VFFSVIHSSYCIGAAVPHFETFAIARG 354

  Fly   429 MSAGSRVFEFLSLQPQVE--LLRGYIIPQERLHGEIRFENVSFAYPMQPDHLVLKDFSLTLRPGQ 491
              |...:|:.:..:|.::  ...||  ..|.:.|.:.|:||||.||.:|...:||..:|.::.|:
Human   355 --AAFHIFQVIDKKPSIDNFSTAGY--KPESIEGTVEFKNVSFNYPSRPSIKILKGLNLRIKSGE 415

  Fly   492 TVALVGASGSGKSTIASLVERFYEPSAGNIKLDGYKLSDISPYWLRSNVLGFIEQQPVLFGTSIL 556
            ||||||.:||||||:..|::|.|:|..|.|.:|...:..::....|.:: |.:.|:||||||:|.
Human   416 TVALVGLNGSGKSTVVQLLQRLYDPDDGFIMVDENDIRALNVRHYRDHI-GVVSQEPVLFGTTIS 479

  Fly   557 ENIRYGKPDAGEEDVYAAARLSQSHDFVTALPDGYATHVGERGTQLSGGQRQRIAIARALLKNPR 621
            .||:||:.|..:|::..|||.:.::||:...|:.:.|.|||:|.|:||||:|||||||||::||:
Human   480 NNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPK 544

  Fly   622 ILILDEATSALDATSEAEVQKALDTVVQNRTTLVIAHRLSTIRNADLIVVLDQGRVVETGKHDEL 686
            ||||||||||||:.|::.||.||:...:.|||:|:||||||||:|||||.|..|.:.|.|.|.||
Human   545 ILILDEATSALDSESKSAVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAEL 609

  Fly   687 MGKRGLYFELVRQQERRDIQEQVQA-------------VEDVVAVKEQQATATETSTAATIATAA 738
            |.|||||:.||..|:.:...||:::             :..|.::|.......|.||.:...:..
Human   610 MAKRGLYYSLVMSQDIKKADEQMESMTYSTERKTNSLPLHSVKSIKSDFIDKAEESTQSKEISLP 674

  Fly   739 ETS 741
            |.|
Human   675 EVS 677

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..702	CDD:440747	206/599 (34%)
ABCB5	NP_001157413.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24
		PTZ00265	8..1251	CDD:240339	215/653 (33%)