DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1824 and ABCB5

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_001157413.1	Gene:	ABCB5 / 340273	HGNCID:	46	Length:	1257	Species:	Homo sapiens

Alignment Length:	653	Identity:	215/653 - (32%)
Similarity:	336/653 - (51%)	Gaps:	69/653 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 LWELIGAVCAALIVAYINIRIPNLL-GDLVNT-LARYAN-TYVMDPINNSFVKDVSKPASNLLSL 191
            |..|:...|..|:...:.....||: |.||.| ...|.| |...:.:|...         .||:|
Human    53 LASLVNGACLPLMPLVLGEMSDNLISGCLVQTNTTNYQNCTQSQEKLNEDM---------TLLTL 108

  Fly   192 YMLQSG-----FTFMYIYLLSRVGEQMAAKMRQDLFTQIVVQDIAFFDENRTGELVNRLTADVQD 251
            |.:..|     |.::.|.|......:...::|:..|..::.|||.:||....|||..|:|.|:..
Human   109 YYVGIGVAALIFGYIQISLWIITAARQTKRIRKQFFHSVLAQDIGWFDSCDIGELNTRMTDDIDK 173

  Fly   252 FKTSFKQFVSQGLRSAAQLIGGSISLFMISP--------HMAAIALASVPCVVMFMTYLGKKLRS 308
                    :|.|:.....|:..::|.|.|..        .:..:.|::.|.::.......:.:.|
Human   174 --------ISDGIGDKIALLFQNMSTFSIGLAVGLVKGWKLTLVTLSTSPLIMASAAACSRMVIS 230

  Fly   309 LSKSSQAQAERATGVCEEALSNIRTVRSSACEYREMQLFEAETNEAARLAQKLGYGIAIFQGLTN 373
            |:....:...:|..|.||.||:||||.:...:.:|:|.:.....:|.....|......:..|...
Human   231 LTSKELSAYSKAGAVAEEVLSSIRTVIAFRAQEKELQRYTQNLKDAKDFGIKRTIASKVSLGAVY 295

  Fly   374 FFLN-TLVLSTLFMGGHLMSTESLSPGALMAFLVASQGVQRSLAQGSILLGTMI---------RG 428
            ||:| |..|:..:....:::.|   ||..:..::|   |..|:...|..:|..:         ||
Human   296 FFMNGTYGLAFWYGTSLILNGE---PGYTIGTVLA---VFFSVIHSSYCIGAAVPHFETFAIARG 354

  Fly   429 MSAGSRVFEFLSLQPQVE--LLRGYIIPQERLHGEIRFENVSFAYPMQPDHLVLKDFSLTLRPGQ 491
              |...:|:.:..:|.::  ...||  ..|.:.|.:.|:||||.||.:|...:||..:|.::.|:
Human   355 --AAFHIFQVIDKKPSIDNFSTAGY--KPESIEGTVEFKNVSFNYPSRPSIKILKGLNLRIKSGE 415

  Fly   492 TVALVGASGSGKSTIASLVERFYEPSAGNIKLDGYKLSDISPYWLRSNVLGFIEQQPVLFGTSIL 556
            ||||||.:||||||:..|::|.|:|..|.|.:|...:..::....|.:: |.:.|:||||||:|.
Human   416 TVALVGLNGSGKSTVVQLLQRLYDPDDGFIMVDENDIRALNVRHYRDHI-GVVSQEPVLFGTTIS 479

  Fly   557 ENIRYGKPDAGEEDVYAAARLSQSHDFVTALPDGYATHVGERGTQLSGGQRQRIAIARALLKNPR 621
            .||:||:.|..:|::..|||.:.::||:...|:.:.|.|||:|.|:||||:|||||||||::||:
Human   480 NNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPK 544

  Fly   622 ILILDEATSALDATSEAEVQKALDTVVQNRTTLVIAHRLSTIRNADLIVVLDQGRVVETGKHDEL 686
            ||||||||||||:.|::.||.||:...:.|||:|:||||||||:|||||.|..|.:.|.|.|.||
Human   545 ILILDEATSALDSESKSAVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAEL 609

  Fly   687 MGKRGLYFELVRQQERRDIQEQVQA-------------VEDVVAVKEQQATATETSTAATIATAA 738
            |.|||||:.||..|:.:...||:::             :..|.::|.......|.||.:...:..
Human   610 MAKRGLYYSLVMSQDIKKADEQMESMTYSTERKTNSLPLHSVKSIKSDFIDKAEESTQSKEISLP 674

  Fly   739 ETS 741
            |.|
Human   675 EVS 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	205/598 (34%)
		ABC_membrane	137..415	CDD:279056	68/294 (23%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	123/237 (52%)
ABCB5	NP_001157413.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		PTZ00265	8..1251	CDD:240339	215/653 (33%)
		ABC_membrane	52..333	CDD:279056	71/302 (24%)
		ABC_MTABC3_MDL1_MDL2	386..623	CDD:213216	123/237 (52%)
		ABC_membrane	696..962	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1016..1254	CDD:213216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810