DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1824 and Abcc10

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_001101671.1	Gene:	Abcc10 / 316231	RGDID:	1306696	Length:	1494	Species:	Rattus norvegicus

Alignment Length:	759	Identity:	185/759 - (24%)
Similarity:	303/759 - (39%)	Gaps:	164/759 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VSNCGRSSDIFSRHLLQPTQQPLPRLQN----------------AARLMRQHLRGTNAPQPPAIP 54
            |::.|:|..:   |.|:.|.:.|...||                |..:.|.:.|...:....||
  Rat   829 VTDSGQSPSV---HNLEKTTEELDVAQNTSGRLVQEESKSEGAVALHVYRAYWRAMGSGLATAI- 889

  Fly    55 PTNASRLLQTTRLLVWGGGSLAIGLGARSWWAGHRGAIVHCEGSRLAIRKEEEEEDTASEQHFDW 119
             ..:..|:|.||             ....||..|       ..|:|...:...||..||..
  Rat   890 -LISLLLMQATR-------------NGADWWLAH-------WLSQLKAGRNSSEERPASSS---- 929

  Fly   120 KRLWTYLEPHLWELIGAVCAALIVAYINIRIPNLLGDLVNTLARYANTYVMDPINNSFVKDVSKP 184
            .|...:..|.|          |:.:..|:.||                             :.|.
  Rat   930 PRSMGFFSPRL----------LLFSPGNLYIP-----------------------------LHKA 955

  Fly   185 ASN-------LLSLYMLQSGF----TFMYIYLLSRVGEQMAAKMRQDLFTQIVVQDIAFFDENRT 238
            .||       .|::|...:|.    |.:...|.:....|.||.:...|..::::..:.|:|...:
  Rat   956 TSNGSSDVHFYLTVYATIAGVNSLCTLLRAVLFAAGALQAAASLHHRLLHRLLMAPVTFYDSTPS 1020

  Fly   239 GELVNRLTADVQDFKTSFKQFVSQGLRSAAQLIGGSISLFMISPHMAAIALASVPCVVMFM---- 299
            |.::||.::||.....|....::..|.::..|:|           :.|:..:.:|.:::.:
  Rat  1021 GRVLNRFSSDVACVDDSLPFLLNILLANSVGLLG-----------LLAVLGSGLPWLLLLLPPLS 1074

  Fly   300 -TYLG------KKLRSLSKSSQAQAERATGVCEEALSNIRTVRSSACEYREMQLFEAETNEAARL 357
             .|.|      ...|.|.:..............:.|:.:..:|::...||    ||.|......|
  Rat  1075 FIYYGVQRRYRASFRELRRLGSLTLSPLYSHLADTLAGLPVLRAAGATYR----FEEENQRLLEL 1135

  Fly   358 AQKLGYGIAIFQGLTNFFLNTLVLSTLFMGGHLMSTESLSPGALMAFLVASQGVQRSLAQGSIL- 421
            .|:..            |.:...:..|.:...||....:|..|.:|.:...||:......|.:|
  Rat  1136 NQRCQ------------FASYATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLVLS 1188

  Fly   422 LGTMIRGMSAG--SRVFEFLSLQPQVELLRGYI--IPQERLHGE----------------IRFEN 466
            ....:.|:.:|  |...:..::...||.|..|.  ||||. ||:                :.|::
  Rat  1189 YALSLTGLLSGLVSSFTQTEAMMVSVERLEEYSCDIPQEP-HGQPPQSPHQRVSWLTQGSVEFQD 1252

  Fly   467 VSFAY-PMQPDHLVLKDFSLTLRPGQTVALVGASGSGKSTIASLVERFYEPSAGNIKLDGYKLSD 530
            |...| |..|:  .|...:..:.||:.:.:||.:|||||::..::.|..|||||.:.|||...|.
  Rat  1253 VVLVYRPGLPN--ALDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRLLEPSAGQVLLDGVDTSQ 1315

  Fly   531 ISPYWLRSNVLGFIEQQPVLFGTSILENIRYGKPDAGEEDVYAAARLSQSHDFVTALP-DGYATH 594
            :....|||. |..|.|:|.||..::.||:   .|....||......|.|.|....|:. .|....
  Rat  1316 LELAELRSQ-LAVIPQEPFLFSGTVRENL---DPQGLHEDRALWQALEQCHLSEVAMAIGGLDGE 1376

  Fly   595 VGERGTQLSGGQRQRIAIARALLKNPRILILDEATSALDATSEAEVQKALDTVVQNRTTLVIAHR 659
            :||||..||.||||.:.:|||||.:.:||.:||||:::|..::..:|:.:.....|:|.|.||||
  Rat  1377 LGERGRDLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICRRFANKTVLTIAHR 1441

  Fly   660 LSTIRNADLIVVLDQGRVVETGKHDELMGK-RGLYFELVRQQER 702
            |:||.|:|.::||..|||||......|..: ..|:.:|::..::
  Rat  1442 LNTILNSDRVLVLQAGRVVELDSPSALRNQPHSLFRQLLQSSQQ 1485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	158/627 (25%)
		ABC_membrane	137..415	CDD:279056	51/299 (17%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	89/240 (37%)
Abcc10	NP_001101671.1	CFTR_protein	211..1485	CDD:273530	185/757 (24%)
		ABC_membrane	290..552	CDD:294371
		ABCC_MRP_domain1	599..802	CDD:213217
		ABC_membrane	957..1190	CDD:294371	48/259 (19%)
		PBP2_NikA_DppA_OppA_like	<1201..>1274	CDD:294989	17/75 (23%)
		ABCC_MRP_domain2	1246..1465	CDD:213211	86/224 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000