DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1824 and Abcc6

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	XP_006541009.1	Gene:	Abcc6 / 27421	MGIID:	1351634	Length:	1500	Species:	Mus musculus

Alignment Length:	749	Identity:	169/749 - (22%)
Similarity:	307/749 - (40%)	Gaps:	155/749 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 QQPLPRLQN-------AARLMRQHLRGTNAPQPPAI--------PPTNASRLLQTTRLLVWGGGS 74
            |:||..|..       .|.|:...|    ..|||..        |...|.....:..:..|..|.
Mouse   236 QEPLHHLATYLCLSLVVAELVLSCL----VDQPPFFSEDSQPLNPCPEAEASFPSKAMFWWASGL 296

  Fly    75 LAIG----LGARSWWAGHRGAIVHCEGSRLAIRKEEEEEDTASEQHFDWKRLWTYLEPHLWELIG 135
            |..|    ||.:..|               ::.:|...|:..|:...:|:|....|..|...  .
Mouse   297 LWRGYKKLLGPKDLW---------------SLGRENSSEELVSQLEREWRRSCNGLPGHKGH--S 344

  Fly   136 AVCAALIVAYINIRIP--NLLGDLVNTLAR-YANTYVMDP----INNSFVKDVSKPASNLLSLYM 193
            :|.|....|::.   |  :..|.|:..:.| :.:|:::..    |:::|...|.|    ||||::
Mouse   345 SVGAPETEAFLQ---PERSQRGPLLRAIWRVFRSTFLLGTLSLVISDAFRFAVPK----LLSLFL 402

  Fly   194 -------------------------LQSGFTFMYIYLLSRVGEQMAAKMRQDLFTQIVVQDIAFF 233
                                     ||:.|...::|....:..::...:...::.:::|......
Mouse   403 EFMGDRNSSAWTGWLLAVLMFAAACLQTLFEQQHMYRAKVLQMRLRTAITGLVYRKVLVLSSGSR 467

  Fly   234 DENRTGELVNRLTADVQDFKTS--------------FKQFVSQGLRSAAQLIGGSISLFMISPHM 284
            ..:..|::||.::.|:|....|              |..||     ...||:|.| :|..:
Mouse   468 KSSAAGDVVNLVSVDIQRLAESIIYLNGLWLLFLWIFVCFV-----YLWQLLGPS-ALTAV---- 522

  Fly   285 AAIALASVPCVVMFMTYLGKKLRSLSKSSQ--AQAERATGVCEEALSNIRTVRSSACEYREMQ-L 346
             |:.|:.:| :..|:|    |.|...:..|  .:|.||. :....|..:||::|...|:..:: |
Mouse   523 -AVFLSLLP-LNFFIT----KKRGFHQEEQMRQKASRAR-LTSSMLRTVRTIKSHGWEHAFLERL 580

  Fly   347 FEAETNEAARL-AQKLGYGIAIFQGLTNFFLNTLVLSTLFMGGHLMSTESLSPGALMAFLVASQG 410
            ......|.:.| ...|.:.::    |.:|.::|.:::.:....|.:..|..:..|..||:..:..
Mouse   581 LHIRGQELSALKTSTLLFSVS----LVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVL 641

  Fly   411 VQRSLAQGSILLGT--MIRGMSAGSRVFEFLSLQPQVELLRGYIIPQERLHGE--IRFENVSFAY 471
            ...:.||..:....  :::...:..|:..||.|: :|: ..|.|....|...:  |...|.:||:
Mouse   642 SILNKAQAFLPFSVHCIVQARVSFDRLAAFLCLE-EVD-PNGMIASNSRRSSKDRISVHNGTFAW 704

  Fly   472 PMQPDHLVLKDFSLTLRPGQTVALVGASGSGKSTIASLVERFYEPSAGNIKLDGYKLSDISPYWL 536
             .|.....|...:||:..|..:|:||..|:|||::.|.:........|::.::|
Mouse   705 -SQESPPCLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIEG----------- 757

  Fly   537 RSNVLGFIEQQPVLFGTSILENIRYGKPDAGEED------VYAAARLSQSHDFVTALPDGYATHV 595
               .:.::.|:..:..||::||:.:.:    |.|      |..|..|...   |.:.|.|..|.:
Mouse   758 ---SVAYVPQEAWVQNTSVVENVCFRQ----ELDLPWLQKVLDACALGSD---VASFPAGVHTPI 812

  Fly   596 GERGTQLSGGQRQRIAIARALLKNPRILILDEATSALDATSEAEVQKAL---DTVVQNRTTLVIA 657
            ||:|..|||||:||:::|||:.|...|.:||:..:||||....:|.|.:   ..::|..|.:::.
Mouse   813 GEQGMNLSGGQKQRLSLARAVYKKAAIYLLDDPLAALDAHVSQQVFKQVIGPSGLLQGTTRILVT 877

  Fly   658 HRLSTIRNADLIVVLDQGRVVETGKHDELMGKRG 691
            |.|..:..||.|:||..|.:.|.|.:.:|:.:.|
Mouse   878 HTLHVLPQADRILVLANGTIAEMGSYQDLLQRNG 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	147/636 (23%)
		ABC_membrane	137..415	CDD:279056	63/327 (19%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	70/239 (29%)
Abcc6	XP_006541009.1	MRP_assoc_pro	101..1465	CDD:188098	169/749 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000