DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1824 and Tap1

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_114444.2	Gene:	Tap1 / 24811	RGDID:	3817	Length:	725	Species:	Rattus norvegicus

Alignment Length:	716	Identity:	223/716 - (31%)
Similarity:	352/716 - (49%)	Gaps:	90/716 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 PAIPPTNASRLLQTTRLLVWG-------------GGSLAIGLGARSWWAGHRGAIVHCEGSRL-- 100
            |.:|...:..:.:...|.||.             .|.|.:..|||.|.|..: .:|...|..|
  Rat    23 PVLPGIFSLLVPEVPLLRVWAVGLSRWAILGLGVRGVLGVTAGARGWLAALQ-PLVAALGLALPG 86

  Fly   101 --AIRKEE-----EEEDTASEQHFDWKRLWTYLEPH--------LWELIGAVCAALIVAYINIRI 150
              :.||..     .|.|.|...|:: .||..::..:        ||..:|...|..........:
  Rat    87 LASFRKLSAWGALREGDNAGLLHWN-SRLDAFVLSYVAALPAAALWHKLGGFWAPSGHKGAGDML 150

  Fly   151 PNLLGDL---------------VNTLARYANTYVMDPINNSFVKDVSKP--ASNLLSLYMLQSGF 198
            ..:||.|               ::.|...|..:....|.:..::|.:.|  |.|:..:.:|....
  Rat   151 CRMLGFLDSKKGRLHLVLVLLILSCLGEMAIPFFTGRITDWILQDKTAPSFARNMWLMCILTVAS 215

  Fly   199 TFMY-----IYLLSRVGEQMAAKMRQDLFTQIVVQDIAFFDENRTGELVNRLTAD-------VQD 251
            |.:.     ||.:: :| .|.:::..::|..::.|:..||.:|.||.:.:|:|.|       :.|
  Rat   216 TALEFAGDGIYNIT-MG-HMHSRVHGEVFRAVLHQETGFFLKNPTGSITSRVTEDTSNVCESISD 278

  Fly   252 FKTSFKQFVSQGLRSAAQLIGGSISLFMISPHMAAIALASVPCVVMFMTYLGKKLRSLSKSSQAQ 316
            ....|..::.:||...|.:|.||.       ::..:.|.|:|.:.:....|||..:||:...|..
  Rat   279 KLNLFLWYLGRGLCLLAFMIWGSF-------YLTVVTLLSLPLLFLLPRRLGKVYQSLAVKVQES 336

  Fly   317 AERATGVCEEALSNIRTVRSSACEYREMQLFEAETNEAARLAQK--LGYGIAIFQGLTNFFLNTL 379
            ..::|.|..||||.:.||||.|.|..|.|.|..:..|...|.:|  |.|...::....:..|  |
  Rat   337 LAKSTQVALEALSAMPTVRSFANEEGEAQKFRQKLEEMKPLNKKEALAYVTEVWTMSVSGML--L 399

  Fly   380 VLSTLFMGGHLMSTESLSPGALMAFLVASQGVQRSLAQGSILLG---TMIRGMSAGSRVFEFLSL 441
            .:..|::||.|:...::|.|.|::|::......|::   .:||.   :|.:.:.|..::||:|..
  Rat   400 KVGILYLGGQLVVRGAVSSGNLVSFVLYQLQFTRAV---EVLLSIYPSMQKSVGASEKIFEYLDR 461

  Fly   442 QPQVELLRGYIIPQERLHGEIRFENVSFAYPMQPDHLVLKDFSLTLRPGQTVALVGASGSGKSTI 506
            .| ...|.|.:.|. .:.|.::|::||||||..|:..||:..:.||.||:..||||.:||||||:
  Rat   462 TP-CSPLSGSLAPL-NMKGLVKFQDVSFAYPNHPNVQVLQGLTFTLYPGKVTALVGPNGSGKSTV 524

  Fly   507 ASLVERFYEPSAGNIKLDGYKLSDISPYWLRSNVLGFIEQQPVLFGTSILENIRYG---KPDAGE 568
            |:|::..|:|:.|.:.|||..|.....::|.:.|.. :.|:|:|||.|..|||.||   .|..
  Rat   525 AALLQNLYQPTGGKVLLDGELLVQYDHHYLHTQVAA-VGQEPLLFGRSFRENIAYGLTRTPTM-- 586

  Fly   569 EDVYAAARLSQSHDFVTALPDGYATHVGERGTQLSGGQRQRIAIARALLKNPRILILDEATSALD 633
            |::.|.|..|.:|||::..|.||.|.|||.|.||||||||.:|:||||::.||:||||:||||||
  Rat   587 EEITAVAMESGAHDFISGFPQGYDTEVGETGNQLSGGQRQAVALARALIRKPRLLILDDATSALD 651

  Fly   634 ATSEAEVQKALDTVVQ--NRTTLVIAHRLSTIRNADLIVVLDQGRVVETGKHDELMGKRGLYFEL 696
            |.::..||:.|....:  :||.|:|..:||....|..|:.|.:|.|.|.|.|.:||.:.|.|..:
  Rat   652 AGNQLRVQRLLYESPEWASRTVLLITQQLSLAERAHHILFLKEGSVCEQGTHLQLMERGGCYRSM 716

  Fly   697 V 697
            |
  Rat   717 V 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	202/626 (32%)
		ABC_membrane	137..415	CDD:279056	75/308 (24%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	110/241 (46%)
Tap1	NP_114444.2	3a01208	2..717	CDD:273363	222/714 (31%)
		ABC_membrane	177..435	CDD:279056	70/268 (26%)
		Part of the peptide-binding site. /evidence=ECO:0000250\|UniProtKB:Q03518	352..397		14/44 (32%)
		Part of the peptide-binding site. /evidence=ECO:0000250\|UniProtKB:Q03518	430..464		9/37 (24%)
		P-loop_NTPase	469..697	CDD:304359	104/231 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0058
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D684058at2759
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820