DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1824 and ABCB10

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_036221.2	Gene:	ABCB10 / 23456	HGNCID:	41	Length:	738	Species:	Homo sapiens

Alignment Length:	670	Identity:	247/670 - (36%)
Similarity:	387/670 - (57%)	Gaps:	27/670 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 ARLMRQHLRGTNAPQPPAIPPTNASRLLQTTRLLVWGGGSLAIGLGARSWWAGHRGAIVHCEGSR 99
            |||:....||..:.:..|.....|.||   .|....||.:.|...|..:|..|....    .|.:
Human    87 ARLLGLWARGPGSCRCGAFAGPGAPRL---PRARFPGGPAAAAWAGDEAWRRGPAAP----PGDK 144

  Fly   100 LAIRKEEEEEDTASEQHFDWKRLWTYLEPHLWELIGAVCAALIVAYINIRIPNLLGDLVNTLARY 164
            ..:|       .|:....:.::|.....|....|..||....:.:.|::..|..||.:::.:  |
Human   145 GRLR-------PAAAGLPEARKLLGLAYPERRRLAAAVGFLTMSSVISMSAPFFLGKIIDVI--Y 200

  Fly   165 ANTYVMDPINNSFVKDVSKPASNLLSLYMLQSGFTFMYIYLLSRVGEQMAAKMRQDLFTQIVVQD 229
            .|..|      .:..::::....|.::::..:....:.:||:...|:::..::|..||:.|:.|:
Human   201 TNPTV------DYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQE 259

  Fly   230 IAFFDENRTGELVNRLTADVQDFKTSFKQFVSQGLRSAAQLIGGSISLFMISPHMAAIALASVPC 294
            :||||:.|||||:|||::|......|..:.:|.|||:.||...|...:|.:||::|...|:.||.
Human   260 VAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPP 324

  Fly   295 VVMFMTYLGKKLRSLSKSSQAQAERATGVCEEALSNIRTVRSSACEYREMQLFEAETNEAARLAQ 359
            |.:.....|:.||.|:|.:|....:||.:.||.:.|:||||:...|..|::.:.::.:...:||:
Human   325 VSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLAR 389

  Fly   360 KLGYGIAIFQGLTNFFLNTLVLSTLFMGGHLMSTESLSPGALMAFLVASQGVQRSLAQGSILLGT 424
            |..:..|.|.|.|....|.:|||.|:.||.||.:..::.|.|.:||:.:..|..|:...|.....
Human   390 KEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSE 454

  Fly   425 MIRGMSAGSRVFEFLSLQPQVELLRGYIIPQERLHGEIRFENVSFAYPMQPDHLVLKDFSLTLRP 489
            :::|:.||.|::|.|..:|::....|.|:.::...|.:.|:||.||||.:|:..:.:||||::..
Human   455 LMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPS 519

  Fly   490 GQTVALVGASGSGKSTIASLVERFYEPSAGNIKLDGYKLSDISPYWLRSNVLGFIEQQPVLFGTS 554
            |...||||.|||||||:.||:.|.|:|::|.|.|||:.:..::|.||||.: |.:.|:|:||..|
Human   520 GSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKI-GTVSQEPILFSCS 583

  Fly   555 ILENIRYGKPDAGE---EDVYAAARLSQSHDFVTALPDGYATHVGERGTQLSGGQRQRIAIARAL 616
            |.|||.||..|...   |::...|.::.:..|:...|.|:.|.|||:|..|||||:|||||||||
Human   584 IAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARAL 648

  Fly   617 LKNPRILILDEATSALDATSEAEVQKALDTVVQNRTTLVIAHRLSTIRNADLIVVLDQGRVVETG 681
            ||||:||:||||||||||.:|..||:|||.::..||.||||||||||:||:::.|||||::.|.|
Human   649 LKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYG 713

  Fly   682 KHDELMGK-RGLYFELVRQQ 700
            ||:||:.| .|:|.:|:.:|
Human   714 KHEELLSKPNGIYRKLMNKQ 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	228/586 (39%)
		ABC_membrane	137..415	CDD:279056	84/277 (30%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	127/241 (53%)
ABCB10	NP_036221.2	mitochondrial targeting sequence	1..105		5/17 (29%)
		PWWP	1..>26	CDD:295359
		MdlB	163..734	CDD:224055	227/580 (39%)
		ABC_membrane	177..438	CDD:279056	82/268 (31%)
		ABC_MTABC3_MDL1_MDL2	493..733	CDD:213216	127/240 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0058
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54509
OrthoDB	1	1.010	-	-		D221577at33208
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.730