Protein Alignment CG1824 and Tap2

DIOPT Version :10

• Sequence 1: NP_572810.1
• Gene: CG1824 / 32208
• FlyBaseID: FBgn0030403
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: NP_035660.3
• Gene: Tap2 / 21355
• MGIID: 98484
• Length: 702
• Species: Mus musculus
• Alignment Length: 664
• Identity: 209/664 - (31%)
• Similarity: 348/664 - (52%)
• Gaps: 57/664 - (8%)

  Fly    58 ASRLLQTTRLLVWGGGSLA-IGLGARSW-W--AGHRGAI-----VHCEGSRLAIRKEEEEEDTAS 113
            |:.|..:.|.||.|..|.: :.:.:.|| |  ||: ||:     |....|...:    :|::...
Mouse    72 ATPLFFSLRALVGGTASTSVVRVASASWGWLLAGY-GAVALSWAVWAVLSPAGV----QEKEPGQ 131

  Fly   114 EQHFDWKRLWTYLEPHLWELIGAVCAALIVAYINIRIPNLLGDLVNTLARYANTYVMDPINNSFV 178
            |.....|||.....|.|..||.|....::..:....||           ||:.. |:|.:...|.
Mouse   132 ENRTLMKRLLKLSRPDLPFLIAAFFFLVVAVWGETLIP-----------RYSGR-VIDILGGDFD 184

  Fly   179 KDVSKPASNLLSLYMLQSGFTF-----MYIYLLSRVGEQMAAKMRQDLFTQIVVQDIAFFDENRT 238
            .|....|...:.|:.:.|.|:.     .:::.:||:.    .::|:.||:.::.||:.||.|.:|
Mouse   185 PDAFASAIFFMCLFSVGSSFSAGCRGGSFLFTMSRIN----LRIREQLFSSLLRQDLGFFQETKT 245

  Fly   239 GELVNRLTADVQDFKTSFKQFVSQGLRSAAQLIGGSISLFMISPHMAAIALASVPCVVMFMTYLG 303
            |||.:||::|............:..|||..:::|....:..:||.:..::|..:|..:.......
Mouse   246 GELNSRLSSDTSLMSRWLPFNANILLRSLVKVVGLYFFMLQVSPRLTFLSLLDLPLTIAAEKVYN 310

  Fly   304 KKLRSLSKSSQAQAERATGVCEEALSNIRTVRSSACEYREMQLFEAETNEAARLAQKLGYG---- 364
            .:.:::.|..|....:|..|..||:..::||||...|.:|:..::    ||....::|.:.
Mouse   311 PRHQAVLKEIQDAVAKAGQVVREAVGGLQTVRSFGAEEQEVSHYK----EALERCRQLWWRRDLE 371

  Fly   365 ---IAIFQGLTNFFLNTLVLSTLFMGGHLMSTESLSPGALMAFLVASQGVQRSLAQGSILLGTMI 426
               ..:.:.:....:..|:|:   .|...:....::.|.|::||:..:.|.:.:.....:.|.|:
Mouse   372 KDVYLVIRRVMALGMQVLILN---CGVQQILAGEVTRGGLLSFLLYQEEVGQYVRNLVYMYGDML 433

  Fly   427 RGMSAGSRVFEFLSLQPQVELLRGYIIPQERLHGEIRFENVSFAYPMQPDHLVLKDFSLTLRPGQ 491
            ..:.|..:||.:|..:|  .|.:..|:....|.|.:.|::|||:||.:|:..||:..:.||.||.
Mouse   434 SNVGAAEKVFSYLDRKP--NLPQPGILAPPWLEGRVEFQDVSFSYPRRPEKPVLQGLTFTLHPGT 496

  Fly   492 TVALVGASGSGKSTIASLVERFYEPSAGNIKLDGYKLSDISPYWLRSNVLGFIEQQPVLFGTSIL 556
            ..||||.:||||||:|:|::..|:|:.|.:.|||..|::...::|...|: .:.|:||||..|:.
Mouse   497 VTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGEPLTEYDHHYLHRQVV-LVGQEPVLFSGSVK 560

  Fly   557 ENIRYGKPDAGEEDVYAAARLSQSHDFVTALPDGYATHVGERGTQLSGGQRQRIAIARALLKNPR 621
            :||.||..|..:..|.|||:.:.:.||:..:.:|..|.:||:|.||:.||:||:||||||::|||
Mouse   561 DNIAYGLRDCEDAQVMAAAQAACADDFIGEMTNGINTEIGEKGGQLAVGQKQRLAIARALVRNPR 625

  Fly   622 ILILDEATSALDATSEAEVQKALDTVVQNRTTLVIAHRLSTIRNADLIVVLDQGRVVETGKHDEL 686
            :||||||||||||..|..:|.....  .:||.|||||||.|::|||.::||.|||:||   ||:|
Mouse   626 VLILDEATSALDAQCEQALQNWRSQ--GDRTMLVIAHRLHTVQNADQVLVLKQGRLVE---HDQL 685

  Fly   687 MGKRGLYFELVRQQ 700
            ...:.:|..||:|:
Mouse   686 RDGQDVYAHLVQQR 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..702	CDD:440747	191/594 (32%)
Tap2	NP_035660.3	3a01208	1..696	CDD:273363	206/659 (31%)
		Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03519	300..388		16/91 (18%)
		Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03519	413..432		2/18 (11%)