DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1824 and Tap1

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_038711.2	Gene:	Tap1 / 21354	MGIID:	98483	Length:	724	Species:	Mus musculus

Alignment Length:	729	Identity:	224/729 - (30%)
Similarity:	353/729 - (48%)	Gaps:	99/729 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LMRQHLRGTNAPQPPAIPPTNASRLLQT-----TRLLVWG---GGSLAIGLGARSWWAGHRG--A 91
            |:|..|.|..:...|.:|      ||:.     :|..:.|   .|.|.:..||..|.|..:.  |
Mouse    19 LLRPMLPGIFSLLVPEVP------LLRVWVVGLSRWAILGLGVRGVLGVTAGAHGWLAALQPLVA 77

  Fly    92 IVHCEGSRLAIRKE------EEEEDTASEQHFD-------------------WKRLWTYLEPH-- 129
            .:......||:.:|      ..|.|:|...:::                   |.:|.:...|.
Mouse    78 ALSLALPGLALFRELAAWGTLREGDSAGLLYWNSRPDAFAISYVAALPAAALWHKLGSLWAPSGN 142

  Fly   130 ------LWELIG----------AVCAALIVAYI-NIRIPNLLGDLVNTLARYANTYVMDPINNSF 177
                  |..::|          .|...||::.: .:.||...|       |..:..:.|....||
Mouse   143 RDAGDMLCRMLGFLGPKKRRLYLVLVLLILSCLGEMAIPFFTG-------RITDWILQDKTVPSF 200

  Fly   178 VKDVSKPASNLLSLYMLQS---GFTFMYIYLLSRVGEQMAAKMRQDLFTQIVVQDIAFFDENRTG 239
            .:::.     |:|:..:.|   .|....||.:: :| .|..::.:::|..::.|:..||.:|..|
Mouse   201 TRNIW-----LMSILTIASTALEFASDGIYNIT-MG-HMHGRVHREVFRAVLRQETGFFLKNPAG 258

  Fly   240 ELVNRLTADVQDFKTSFKQFVSQGLRSAAQLIGGSISLFMISPHMAAIALASVPCVVMFMTYLGK 304
            .:.:|:|.|..:...|....:|..|....:.:...:.:|..||::..:.|.::|.:.:....|||
Mouse   259 SITSRVTEDTANVCESISGTLSLLLWYLGRALCLLVFMFWGSPYLTLVTLINLPLLFLLPKKLGK 323

  Fly   305 KLRSLSKSSQAQAERATGVCEEALSNIRTVRSSACEYREMQLFEAETNEAARLAQK--LGYGIAI 367
            ..:||:...|....::|.|..||||.:.||||.|.|..|.|.|..:..|...|.:|  |.|...:
Mouse   324 VHQSLAVKVQESLAKSTQVALEALSAMPTVRSFANEEGEAQKFRQKLEEMKTLNKKEALAYVAEV 388

  Fly   368 FQGLTNFFLNTLVLSTLFMGGHLMSTESLSPGALMAF----LVASQGVQRSLAQGSILLGTMIRG 428
            :....:..|  |.:..|::||.|:...::|.|.|::|    |..:|.||..|:    |..:|.:.
Mouse   389 WTTSVSGML--LKVGILYLGGQLVIRGAVSSGNLVSFVLYQLQFTQAVQVLLS----LYPSMQKA 447

  Fly   429 MSAGSRVFEFLSLQPQVELLRGYIIPQERLHGEIRFENVSFAYPMQPDHLVLKDFSLTLRPGQTV 493
            :.:..::||:|...| ...|.|.:.| ..:.|.:.|::||||||.||...||:..:.||.||...
Mouse   448 VGSSEKIFEYLDRTP-CSPLSGSLAP-SNMKGLVEFQDVSFAYPNQPKVQVLQGLTFTLHPGTVT 510

  Fly   494 ALVGASGSGKSTIASLVERFYEPSAGNIKLDGYKLSDISPYWLRSNVLGFIEQQPVLFGTSILEN 558
            ||||.:||||||:|:|::..|:|:.|.:.|||..|.....::|.:.|.. :.|:|:|||.|..||
Mouse   511 ALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGQCLVQYDHHYLHTQVAA-VGQEPLLFGRSFREN 574

  Fly   559 IRYG---KPDAGEEDVYAAARLSQSHDFVTALPDGYATHVGERGTQLSGGQRQRIAIARALLKNP 620
            |.||   .|..  |::.|.|..|.:|||::..|.||.|.|||.|.||||||||.:|:||||::.|
Mouse   575 IAYGLNRTPTM--EEITAVAVESGAHDFISGFPQGYDTEVGETGNQLSGGQRQAVALARALIRKP 637

  Fly   621 RILILDEATSALDATSEAEVQKAL--DTVVQNRTTLVIAHRLSTIRNADLIVVLDQGRVVETGKH 683
            .:||||:|||||||.::..||:.|  .....:||.|:|..:||....|..|:.|.:|.|.|.|.|
Mouse   638 LLLILDDATSALDAGNQLRVQRLLYESPKRASRTVLLITQQLSLAEQAHHILFLREGSVGEQGTH 702

  Fly   684 DELMGKRGLYFELV 697
            .:||.:.|.|..:|
Mouse   703 LQLMKRGGCYRAMV 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	201/612 (33%)
		ABC_membrane	137..415	CDD:279056	75/287 (26%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	110/241 (46%)
Tap1	NP_038711.2	3a01208	21..716	CDD:273363	222/725 (31%)
		ABC_membrane	176..434	CDD:279056	70/273 (26%)
		Part of the peptide-binding site. /evidence=ECO:0000250\|UniProtKB:Q03518	351..396		14/44 (32%)
		Part of the peptide-binding site. /evidence=ECO:0000250\|UniProtKB:Q03518	429..463		10/38 (26%)
		P-loop_NTPase	468..696	CDD:304359	104/231 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0058
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D684058at2759
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820