DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1824 and Abcb4

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_032856.2	Gene:	Abcb4 / 18670	MGIID:	97569	Length:	1276	Species:	Mus musculus

Alignment Length:	636	Identity:	214/636 - (33%)
Similarity:	319/636 - (50%)	Gaps:	86/636 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 NLLGDLVNTLARYAN------------------------TYVMDPINNSFVKDV---SKPASNLL 189
            ||:|.|  ||.||::                        ..|...:.:.||.:.   |.|.:  .
Mouse    35 NLIGLL--TLFRYSDWQDKLFMFLGTLMAIAHGSGLPLMMIVFGEMTDKFVDNTGNFSLPVN--F 95

  Fly   190 SLYMLQSGFTF-----MYIYLLSRVGE-------------QMAA-----KMRQDLFTQIVVQDIA 231
            ||.||..|...     .|.|..|.:|.             .:||     |:||..|..|:.|::.
Mouse    96 SLSMLNPGRILEEEMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGRQIKKIRQKFFHAILRQEMG 160

  Fly   232 FFDENRTGELVNRLTADVQDFKTSFKQFVSQGLRSAAQLIGGSISLFMISPHMAAIALASVPCVV 296
            :||...|.||..|||.||..........|....::.|....|.|..|:....:..:.:|..|.:.
Mouse   161 WFDIKGTTELNTRLTDDVSKISEGIGDKVGMFFQAIATFFAGFIVGFIRGWKLTLVIMAISPILG 225

  Fly   297 MFMTYLGKKLRSLSKSSQAQAERATGVCEEALSNIRTVRSSACEYREMQLFEAETNEAARLAQK- 360
            :......|.|.:.|....|...:|..|.||||..||||.:...:.:|::.::.....|.::..|
Mouse   226 LSTAVWAKILSTFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKKIGIKK 290

  Fly   361 -----LGYGIAIF-----QGLTNFFLNTLVLSTLFMGGHLMST-ESLSPGALMAFLVASQGVQRS 414
                 :..|||..     ..|..::.:|||:|..:..|:.|:. .|:..||.            |
Mouse   291 AISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAF------------S 343

  Fly   415 LAQGSILLGTMIRGMSAGSRVFEFLSLQPQVELL--RGYIIPQERLHGEIRFENVSFAYPMQPDH 477
            :.|.:..:........|...:|:.:...|:::..  ||:  ..:.:.|.:.|.:|.|:||.:.:.
Mouse   344 VGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGH--KPDNIKGNLEFSDVHFSYPSRANI 406

  Fly   478 LVLKDFSLTLRPGQTVALVGASGSGKSTIASLVERFYEPSAGNIKLDGYKLSDISPYWLRSNVLG 542
            .:||..:|.::.||||||||.||.||||...|::|.|:|:.|.|.:||..:.:.:...|| .::|
Mouse   407 KILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGKISIDGQDIRNFNVRCLR-EIIG 470

  Fly   543 FIEQQPVLFGTSILENIRYGKPDAGEEDVYAAARLSQSHDFVTALPDGYATHVGERGTQLSGGQR 607
            .:.|:||||.|:|.||||||:.:...:::..|.:.:.::||:..||..:.|.||:||.||||||:
Mouse   471 VVSQEPVLFSTTIAENIRYGRGNVTMDEIEKAVKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQK 535

  Fly   608 QRIAIARALLKNPRILILDEATSALDATSEAEVQKALDTVVQNRTTLVIAHRLSTIRNADLIVVL 672
            |||||||||::||:||:|||||||||..||||||.|||...:.|||:|||||||||||||:|...
Mouse   536 QRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTIRNADVIAGF 600

  Fly   673 DQGRVVETGKHDELMGKRGLYFELVRQQERRDIQEQVQAVEDVVAVKEQQA 723
            :.|.:||.|.|.|||.|.|:||.||..|   ....|:.:.|..|.:.:::|
Mouse   601 EDGVIVEQGSHSELMKKEGIYFRLVNMQ---TAGSQILSEEFEVELSDEKA 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	209/612 (34%)
		ABC_membrane	137..415	CDD:279056	77/324 (24%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	124/237 (52%)
Abcb4	NP_032856.2	PTZ00265	30..1269	CDD:240339	214/636 (34%)
		ABC_membrane	58..342	CDD:279056	68/285 (24%)
		ABC_MTABC3_MDL1_MDL2	392..628	CDD:213216	124/236 (53%)
		Interaction with HAX1. /evidence=ECO:0000250	622..646		7/26 (27%)
		ABC_membrane	712..982	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1031..1270	CDD:213216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810