DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1824 and pgp-8

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_509811.2	Gene:	pgp-8 / 181277	WormBaseID:	WBGene00004002	Length:	1243	Species:	Caenorhabditis elegans

Alignment Length:	651	Identity:	201/651 - (30%)
Similarity:	331/651 - (50%)	Gaps:	66/651 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 EEEEDTASEQHFDWKRLWTYLEPHLWE-------------LIGAVCAALIVAYINIRIPNLLGDL 157
            |.|:.|.:         ||.....:|:             ::.|:|..|...:::.    ..|::
Worm    13 ENEKKTTN---------WTKFVKVVWQCTSKWEKFLFVIGVVSAICTGLTQPFMSY----TFGEV 64

  Fly   158 VNTLARY---ANTYVMDPINNSFVKDVSKPASNLLSLYMLQSGFTFMY-----IYLLSRVGEQMA 214
            .....|.   .|...:||.:.....::.....|.:.::....|..||:     ..|...:|:...
Worm    65 SQAFVRITAAVNNASLDPSDLEKAYEMFHADMNNVVIHFGLVGCAFMFFGFIQFSLFKYIGDNTT 129

  Fly   215 AKMRQDLFTQIVVQDIAFFDENRTGELVNRLTADVQDFKTSFKQFVSQGLRSAAQLIGGSISLFM 279
            .::|.....:::.:|..:||...||.|...|..:::.|:.:|.:.::..:..:.....|:...|.
Worm   130 YRLRHKFILRLLKKDAKYFDTISTGYLSTVLNDNLERFREAFNEKIAFIICFSTDFAIGTALAFY 194

  Fly   280 ISPHMAAIALASVPCVVMFMTYLGKKLRSLS--KSSQAQA---ERATGVCEEALSNIRTVRSSAC 339
            .|     ..|||...|..|...:...|.|.|  ||::.|:   ..|..:..:||.:.:||.|...
Worm   195 TS-----WTLASYGSVFAFGIVISGLLNSTSMMKSNEKQSMHYSNAGAIAFQALCSFKTVISLNG 254

  Fly   340 EYREMQLFEAETNEAARLAQKLGYGIAIFQGLTNFFLNTLVLSTLFMGGHLMSTESLSPGALMAF 404
            :.:|::.:.||..|..:...:..:.:|..:||::||.|.|..:.|::|..|:..::::..|::..
Worm   255 QTQELEKYSAELKEGEKFGSRRAFFLATSRGLSHFFCNALNGTILYVGADLIYNKTMNTVAIVTL 319

  Fly   405 LVASQGVQRSLAQGSILLGTMIRGMSAGSRVFEFLSL----------QPQVELLRGYIIPQERLH 459
            .........||.:..:.:..::..:::.:.:|:.|:.          ..|.:       ..:.:.
Worm   320 FHYMLFSAFSLGEAFLHISYLLNAINSATPIFDVLTSDDDMIENNQDNEQTD-------SNKTIQ 377

  Fly   460 GEIRFENVSFAYPMQPDHLVLKDFSLTLRPGQTVALVGASGSGKSTIASLVERFYEPSAGNIKLD 524
            |.:.|.||.||||.:||..:|:..|..::.|:.:|||||||||||||..|:..||...:|.||:.
Worm   378 GMLSFNNVKFAYPSRPDVDILRGISFDVKQGECIALVGASGSGKSTIVQLLLHFYNIQSGTIKIG 442

  Fly   525 GYKLSDISPYWLRSNVLGFIEQQPVLFGTSILENIRYGKPDAGEEDVYAAARLSQSHDFVTALPD 589
            ...|.||:...|| |.:|.:.|:||||.|:|.||||:|.|:|...::|.|.|.:.::|||..:.|
Worm   443 DSHLHDINLKQLR-NAIGVVSQEPVLFNTTIEENIRFGNPNATSSEIYEALRKANAYDFVCNIKD 506

  Fly   590 GYATHVGERGTQLSGGQRQRIAIARALLKNPRILILDEATSALDATSEAEVQKALDTVVQNRTTL 654
            |..|.|||||.||||||:|||||||.|:|||.||:|||||||||:.||..||.||....:.|||:
Worm   507 GLKTIVGERGAQLSGGQKQRIAIARVLVKNPAILLLDEATSALDSASERAVQLALKKASEGRTTI 571

  Fly   655 VIAHRLSTIRNADLIVVLDQGRVVETGKHDELMGKRGLYFELVRQQ--ERRDIQEQV--QAVEDV 715
            :|||||||||:.|.|:|:..|::.|.|.|:||:.....|..|||.|  :.:.::|.:  |..|:|
Worm   572 IIAHRLSTIRHCDKIMVMSNGKIAEVGSHEELISMDREYSNLVRAQFFDSQSVEEDINGQGAEEV 636

  Fly   716 V 716
            :
Worm   637 I 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	194/619 (31%)
		ABC_membrane	137..415	CDD:279056	58/290 (20%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	125/237 (53%)
pgp-8	NP_509811.2	PTZ00265	29..1241	CDD:240339	196/626 (31%)
		ABC_membrane	44..326	CDD:294371	59/290 (20%)
		ABC_MTABC3_MDL1_MDL2	382..617	CDD:213216	125/235 (53%)
		ABC_membrane	685..953	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1005..1240	CDD:213216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810