DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1824 and pgp-9

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_507487.1	Gene:	pgp-9 / 180165	WormBaseID:	WBGene00004003	Length:	1294	Species:	Caenorhabditis elegans

Alignment Length:	694	Identity:	222/694 - (31%)
Similarity:	354/694 - (51%)	Gaps:	85/694 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 EEEEEDTASEQHFDWK------------RLWTYLE--PHLWELIGAV--CAALI-VAYINIRIPN 152
            :::::|::||...:.|            :|:.|..  ..|...:|.:  ||..: :..::|.:.|
Worm     5 KKKKDDSSSEGSSEKKEEAPPPPKISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGN 69

  Fly   153 LLGDLVNTLARYANTYVMDPINNSFVKDVSKP------ASNLLSLYMLQSGF---TFMYIYLLSR 208
            :..:.| ||    .|..:||.:.:..|..::.      ..|.|....|..|.   .|:.......
Worm    70 VSQNFV-TL----GTIFLDPNSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMV 129

  Fly   209 VGEQMAAKMRQDLFTQIVVQDIAFFDENRTGELVNRLTADVQDFKTSFKQFVSQGLRSAAQLIGG 273
            :.|:::.:.|:..|..::.|:||::|:|.:|.|.|:|..:::..:......|....:..||.|||
Worm   130 ICEKLSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGG 194

  Fly   274 SISLFMISPHMAAIALASVPCVVMFMTYLGKKLRSLSKSSQAQAERATGVCEEALSNIRTVRSSA 338
            ....|.....:..|.::..|.:::...:|.|.|.:.:.....|...|.|:.||.|::||||.:
Worm   195 FAVAFTYDWLLTLIMMSLSPFMMICGLFLAKLLATAATKEAKQYAVAGGIAEEVLTSIRTVIA-- 257

  Fly   339 CEYREMQLFEAETNEAARLAQKLGYG--------IAIFQGLTNFFLNTLVLST----LFMGGHLM 391
                    |..:..|..|....|.:|        ..|..||.:||:  ::.::    .::|.:.:
Worm   258 --------FNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFV--IIYASYCLAFWVGTNFV 312

  Fly   392 STESLSPGALMAFLVASQGVQRSLAQGSILLG-------TMIRGMSAGSRVFEFLSLQPQVELLR 449
            .:..|..|.::.       |..|:..||:.||       |:...:.|.:.::|.:...|:::...
Worm   313 YSGRLESGTVLT-------VFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYS 370

  Fly   450 GYIIPQERLHGEIRFENVSFAYPMQPDHLVLKDFSLTLRPGQTVALVGASGSGKSTIASLVERFY 514
            .......::.|.|....|.|.||.:.|..:||..||..:|||||||||:||.|||||..|::|||
Worm   371 TEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFY 435

  Fly   515 EPSAGNIKLDGYKLSDISPYWLRSNVLGFIEQQPVLFGTSILENIRYGKPDAGEEDVYAAARLSQ 579
            .|.||.|.:|...:.|.:..:|| .::|.:.|:|.||.|||.:|||||:.|..:||:..|.:.:.
Worm   436 NPDAGQILIDDIPIEDFNIKYLR-QLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEAN 499

  Fly   580 SHDFVTALPDGYATHVGERGTQLSGGQRQRIAIARALLKNPRILILDEATSALDATSEAEVQKAL 644
            :.||:...|:|..|.||:||.|:||||:|||||||||::||:||:||||||||||.||:.||.||
Worm   500 AADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSAL 564

  Fly   645 DTVVQNRTTLVIAHRLSTIRNADLIVVLDQGRVVETGKHDELMGKRGLYFELVRQQ--------- 700
            :...:.|||:||||||||:||||.|:|:..|:|:|.|.|:.|:.::|||.|||..|
Worm   565 ENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKP 629

  Fly   701 -----ERRDIQEQVQAVEDVVAVKEQQATATETSTAATIATAAE 739
                 ||| :..|....:..|..|.|::...|...|.....|||
Worm   630 KKKEAERR-MSRQTSQRKGSVNFKTQESQVDEKPGAPPAPEAAE 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	207/640 (32%)
		ABC_membrane	137..415	CDD:279056	64/301 (21%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	127/237 (54%)
pgp-9	NP_507487.1	PTZ00265	28..1262	CDD:240339	218/671 (32%)
		ABC_membrane	50..334	CDD:279056	66/307 (21%)
		ABC_MTABC3_MDL1_MDL2	383..620	CDD:213216	127/237 (54%)
		ABC_membrane	710..977	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1030..1269	CDD:213216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810