DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1824 and haf-2

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_495537.2	Gene:	haf-2 / 174204	WormBaseID:	WBGene00001812	Length:	773	Species:	Caenorhabditis elegans

Alignment Length:	657	Identity:	220/657 - (33%)
Similarity:	340/657 - (51%)	Gaps:	90/657 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 LWTYLEPHLWELIGAVCAALIVAYINIRIPNLLGDLVNTLARYANTYVMDPINNSFVKDVSKPAS 186
            ||..:   :|.::......|:..::....|.....|:||.|..|.|.|.:....: |:| ::.||
Worm   120 LWFSV---IWSILSGFIQVLVWYFVFTSNPFDYHRLLNTTAENAGTSVTETAAET-VRD-TETAS 179

  Fly   187 NLLS--------------LYMLQ----------SGFTFMYIYLLSRV-----------------G 210
            |:.|              |.:|.          |||.|:.:|.|:||                 |
Worm   180 NVESGSSTAPRAPLHKVLLRLLSYCGHQWPWFASGFVFLTVYALARVFIPNYTAQVISDIVNKRG 244

  Fly   211 EQ---------------------------------MAAKMRQDLFTQIVVQDIAFFDENRTGELV 242
            .|                                 :..::|.||||.::.|||||:|..:||:.:
Worm   245 IQALIHSIIVLTCLTATSSLFGGLRGGCFDYATALVTLRIRLDLFTSLIRQDIAFYDTAKTGDTM 309

  Fly   243 NRLTADVQDFKTSFKQFVSQGLRSAAQLIGGSISLFMISPHMAAIALASVPCVVMFMTYLGKKLR 307
            :|||:|.|...::....|:..:|:...|||....:.::|..:|.:...:||.|............
Worm   310 SRLTSDCQTISSTVSTNVNVFMRNGVMLIGALAFMILMSWRLAMVTFIAVPLVGFITKAYSSFYD 374

  Fly   308 SLSKSSQAQAERATGVCEEALSNIRTVRSSACEYREMQLFEAETNEAARLAQKLGYGIAIFQGLT 372
            .:|:..|........:.||.:|.:|||||.|||.:|::.||...:....:.:|.......:....
Worm   375 KISEKLQQTIAETNQMAEEVVSTMRTVRSFACEKKELKRFEDRLSSTLSVNRKKSIAYLFYTWNN 439

  Fly   373 NFFLNTLVLSTLFMGGHLMSTESLSPGALMAFLVASQGVQRSLAQGSILLGTMIRGMSAGSRVFE 437
            .|..|.::::.||.||||:.|..:....|:.||:....:..:|...|.::..::..:.|..:||:
Worm   440 EFCDNAILVAVLFYGGHLVMTGKMEKEQLITFLLYQMQLGENLYYLSYVMSGLMEAVGASRKVFD 504

  Fly   438 FLSLQPQVEL---LRGYIIPQERLHGEIRFENVSFAYPMQPDHLVLKDFSLTLRPGQTVALVGAS 499
            .::.:||.||   .|.::      :|.|.|.:|.|.||.:|::.||||.:|:::.|:||||||.|
Worm   505 LMNRKPQFELDGMQRPFV------NGNITFSHVGFTYPSRPNNPVLKDLTLSIKSGETVALVGPS 563

  Fly   500 GSGKSTIASLVERFYEPSAGNIKLDGYKLSDISPYWLRSNVLGFIEQQPVLFGTSILENIRYGKP 564
            |.|||:|.||:|.||||..|::.|||..:.||:..:....| ..:.|:|||:..|:..||.||..
Worm   564 GGGKSSIVSLIEHFYEPDEGSVTLDGVPIKDINHVYYHQKV-ALVAQEPVLYNGSVRHNILYGCD 627

  Fly   565 DAGEEDVYAAARLSQSHDFVTALPDGYATHVGERGTQLSGGQRQRIAIARALLKNPRILILDEAT 629
            .|.|:|:..|::::..||||..|..||.|:.||:|.|:||||:|||||||||::||.:|||||||
Worm   628 FATEDDMLNASKMANVHDFVMELEKGYDTNCGEKGVQMSGGQKQRIAIARALVRNPAVLILDEAT 692

  Fly   630 SALDATSEAEVQKALDTVVQNRTTLVIAHRLSTIRNADLIVVLDQGRVVETGKHDELM-GKRGLY 693
            ||||..|||.||:||....|.||.:::|||||||..|:.|.|:.:|.:|:.|.|.||| ...|:|
Worm   693 SALDTESEALVQQALSRCAQERTVIIVAHRLSTIEKANKIAVIVKGCLVQMGTHTELMTDTDGMY 757

  Fly   694 FELVRQQ 700
            :.||.:|
Worm   758 YSLVSRQ 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	220/657 (33%)
		ABC_membrane	137..415	CDD:279056	84/351 (24%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	121/238 (51%)
haf-2	NP_495537.2	3a01208	15..761	CDD:273363	217/652 (33%)
		ABC_membrane	215..478	CDD:279056	65/262 (25%)
		ABC_MTABC3_MDL1_MDL2	526..764	CDD:213216	121/238 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0058
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1465
OMA	1	1.010	-	-		QHG54509
OrthoDB	1	1.010	-	-		D684058at2759
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.680