DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1824 and pgp-2

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_001300410.1	Gene:	pgp-2 / 172262	WormBaseID:	WBGene00003996	Length:	1296	Species:	Caenorhabditis elegans

Alignment Length:	639	Identity:	219/639 - (34%)
Similarity:	337/639 - (52%)	Gaps:	54/639 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 LLGDLVNTLARYANT-YV--MDPIN---------NSFVKDVSKPASNLLSLYMLQSGFTFMYIYL 205
            :||.:.....|..|: :|  :|.:|         :.|..:|.|.....|.|.:|....:::.|..
Worm    77 VLGGMTTVFLRAQNSDFVVGVDNVNPEGLVPISLDEFNSEVVKYCIYYLVLGVLMFFTSYVQIAC 141

  Fly   206 LSRVGEQMAAKMRQDLFTQIVVQDIAFFDENRTGELVNRLTADVQDFKTSFKQFVSQGLRS---- 266
            .....|::..|:||:....|:.|.|.:||:.:||.|..|||.|::.        |.:||..
Worm   142 FESYAERLVHKLRQNYLKAILRQQIQWFDKQQTGNLTARLTDDLER--------VREGLGDKFAL 198

  Fly   267 -----AAQLIGGSISLFMISPHMAAIALASVPCVVMFMTYLGKKLRSLSKSSQAQAERATGVCEE 326
                 ||.|.|..:. |..|..|..:.:...|.:|:....:.|.:.:.::..|.....|..:.||
Worm   199 LVQMFAAFLAGYGVG-FFYSWSMTLVMMGFAPLIVLSGAKMSKSMATRTRVEQETYAVAGAIAEE 262

  Fly   327 ALSNIRTVRSSACEYREMQLF--EAETNEAARLAQKLGYGIAIFQGLTNFFLNTLVLSTLFMGGH 389
            ..|:||||.|.....||:..|  ..|......:.:....||.:  |.:|..:.:......:.|..
Worm   263 TFSSIRTVHSLNGHKRELDRFYNALEVGRQTGIVKYCYMGIGV--GFSNLCMYSSYALAFWYGST 325

  Fly   390 LMSTESLSPGALMAFLVASQGVQRSLAQGSIL--LGTMIRGMSAGSRVFEFLSLQPQVE--LLRG 450
            |:..:......|: |.|....:..|.:.|..|  |.:......|.|.|...::..|:::  .|.|
Worm   326 LIINDPTFDRGLI-FTVFFAVLSGSTSLGGALPHLASFGTARGAASTVLRVINSHPKIDPYSLEG 389

  Fly   451 YIIPQERLHGEIRFENVSFAYPMQPDHLVLKDFSLTLRPGQTVALVGASGSGKSTIASLVERFYE 515
            .::  :.:.|:|.|::|.|.||.:.|..|||..||.|:.|..:||||:||.|||||.:|::|||:
Worm   390 ILV--DNMKGDISFKDVHFRYPSRKDIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYD 452

  Fly   516 PSAGNIKLDGYKLSDISPYWLRSNVLGFIEQQPVLFGTSILENIRYGKPDAGEEDVYAAARLSQS 580
            |:.|.:.:||..|.:::.:.||..: |.:.|:||||..:|.|||:.|...|..:.|..|.:::.:
Worm   453 PTKGRVLIDGVDLREVNVHSLREQI-GIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANA 516

  Fly   581 HDFVTALPDGYATHVGERGTQLSGGQRQRIAIARALLKNPRILILDEATSALDATSEAEVQKALD 645
            :||:..|||||.|.|||:|.||||||:|||||||||:|||:||:|||||||||..:|.|||.|||
Worm   517 NDFIKRLPDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGALD 581

  Fly   646 TVVQNRTTLVIAHRLSTIRNADLIVVLDQGRVVETGKHDELMGKRGLYFEL-----VRQQERRDI 705
            .....|||:::|||||||||.|.|.|...|.:||:|.|:|||.|:|:::::     ||||:
Worm   582 QAQAGRTTIIVAHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMTQAQVVRQQQ---- 642

  Fly   706 QEQVQAVEDVVAVKEQQATATETST--AATIATAAETSAATVTVGSSSFGGRAN 757
            ||..:.:||.::.......:.::||  |.:|||:....|..|.: ...|.|:.|
Worm   643 QEAGKDIEDTISESAHSHLSRKSSTRSAISIATSIHQLAEEVEL-IDPFNGQTN 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	203/579 (35%)
		ABC_membrane	137..415	CDD:279056	66/284 (23%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	125/242 (52%)
pgp-2	NP_001300410.1	PTZ00265	56..1286	CDD:240339	219/639 (34%)
		ABC_membrane	61..349	CDD:279056	66/283 (23%)
		ABC_MTABC3_MDL1_MDL2	399..632	CDD:213216	123/233 (53%)
		ABC_membrane	736..999	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1052..1290	CDD:213216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I4876
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810