DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1824 and haf-4

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_001021666.1	Gene:	haf-4 / 171639	WormBaseID:	WBGene00001814	Length:	787	Species:	Caenorhabditis elegans

Alignment Length:	711	Identity:	228/711 - (32%)
Similarity:	368/711 - (51%)	Gaps:	65/711 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 TRLLVWGGGSLAIGLGARSWWAGHRGAIVHCEGSRLAIRKEEEEEDTASEQHFD--------WKR 121
            |..|||...|..|   ..|.|..:   ......|.:.:  |:|:.:.|.:|.|:        .||
Worm   121 TAFLVWNFISAII---LNSSWTRY---FSRTPSSYIIL--EDEDLEVAPKQTFELIFRLLQYCKR 177

  Fly   122 LWTYLEPHLWELIGAVCAALIVAYINIRIPNLLGDLVNTLARYAN-------TYVMDPINNSFVK 179
            .|      ||.:.| .....|.:...|.:|...|.::.|:....:       .|:|     :.:.
Worm   178 EW------LWHISG-FSWLFIYSITRIFVPYYTGQVIATVVATKSYPALSNAVYIM-----TIIS 230

  Fly   180 DVSKPASNLLSLYMLQSGFTFMYIYLLSRVGEQMAAKMRQDLFTQIVVQDIAFFDENRTGELVNR 244
            .||..|:..       .|.:|.|.|      .::...:|.|||..:|.||:||:|.::|||:.:|
Worm   231 LVSAVAAGF-------RGGSFEYAY------ARIQRAIRYDLFHGLVKQDVAFYDAHKTGEVTSR 282

  Fly   245 LTADVQDFKTSFKQFVSQGLRSAAQLIGGSISLFMISPHMAAIALASVPCVVMFMTYLGKKLRSL 309
            |.||.|....:....|:..||:...|:|..|.:..:|..::.:....||.:.:.....|.....|
Worm   283 LAADCQTMSDTVALNVNVFLRNCVMLLGSMIFMMKLSWRLSLVTFILVPIIFVASKIFGTYYDLL 347

  Fly   310 SKSSQAQAERATGVCEEALSNIRTVRSSACEYREMQLFEAETNEAARLAQKLGYGIAIFQGLTNF 374
            |:.:|.....:..|.||.||.:|||||.:||..|...|..:......:.:........|..::..
Worm   348 SERTQDTIAESNDVAEEVLSTMRTVRSFSCENVEADRFYGKLTHTLDVTRTKAIAYIGFLWVSEL 412

  Fly   375 FLNTLVLSTLFMGGHLMSTESLSPGALMAFLVASQGVQRSLAQ-GSILLGTMIRGMSAGSRVFEF 438
            |.:.:::|.|:.||||:.|:.:....|::||:....:..:|.| |.:..|.| :.:.|..:|||:
Worm   413 FQSFIIVSVLWYGGHLVLTQKMKGDLLVSFLLYQMQLGDNLRQMGEVWTGLM-QSVGASRKVFEY 476

  Fly   439 LSLQPQVELLRGYIIPQERLHGEIRFENVSFAYPMQPDHLVLKDFSLTLRPGQTVALVGASGSGK 503
            :..:||:: ..|..:| |.:.|:|.|.||.|:||.:.|..:|||.|.|:.||:||||||.|||||
Worm   477 IDREPQIQ-HNGEYMP-ENVVGKIEFRNVHFSYPTRSDQPILKDLSFTVEPGETVALVGPSGSGK 539

  Fly   504 STIASLVERFYEPSAGNIKLDGYKLSDISPYWLRSNVLGFIEQQPVLFGTSILENIRYGKPDAGE 568
            |:..||:|.||.|:||.:.:||..|.:...:::...: ..:.|:||||..|::||:||| .:..:
Worm   540 SSCISLLENFYVPNAGQVLVDGVPLEEFEHHYIHKKI-ALVGQEPVLFARSVMENVRYG-VEVAD 602

  Fly   569 EDVYAAARLSQSHDFVTALPDGYATHVGERGTQLSGGQRQRIAIARALLKNPRILILDEATSALD 633
            .::..:..::.:|.|:......|.|:|||:|||:||||:|||||||||::.|.||:|||||||||
Worm   603 TEIIRSCEMANAHGFIMQTTLKYETNVGEKGTQMSGGQKQRIAIARALVREPAILLLDEATSALD 667

  Fly   634 ATSEAEVQKALDTVVQNRTTLVIAHRLSTIRNADLIVVLDQGRVVETGKHDELM-GKRGLYFELV 697
            ..||..||:|:...:..::.::|||||||:..||.|||:::|||.:.|.|:.|: ...|.|.:||
Worm   668 TESEHLVQEAIYKNLDGKSVILIAHRLSTVEKADKIVVINKGRVEQIGNHETLLKDTNGTYAKLV 732

  Fly   698 RQQERRDIQEQVQAVEDVVAVKEQQATATETSTAATIATAAETSAATVTVGSSSFGGRANA 758
            ::|...|.:.:          |......:....||:|..|..:....:::.|:||...|::
Worm   733 QRQMMGDQKPR----------KRPAVARSGPQPAASINVAGPSQGNAMSLLSTSFSQSASS 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	203/590 (34%)
		ABC_membrane	137..415	CDD:279056	71/284 (25%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	111/238 (47%)
haf-4	NP_001021666.1	3a01208	16..732	CDD:273363	215/648 (33%)
		ABC_membrane	189..449	CDD:279056	71/277 (26%)
		ABC_MTABC3_MDL1_MDL2	498..735	CDD:213216	111/238 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0058
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54509
OrthoDB	1	1.010	-	-		D684058at2759
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.730