DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1824 and ABCC5

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_005679.2	Gene:	ABCC5 / 10057	HGNCID:	56	Length:	1437	Species:	Homo sapiens

Alignment Length:	608	Identity:	163/608 - (26%)
Similarity:	261/608 - (42%)	Gaps:	130/608 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 NNSFVKDVSKPASNL---LSLYMLQSGFTFMYIYLLSRVGE---------QMAAKMRQDLFTQIV 226
            |.:.|.|..|...::   .|:|.|.     |.:.|:.:...         :.::::..:||.:|:
Human   897 NETSVSDSMKDNPHMQYYASIYALS-----MAVMLILKAIRGVVFVKGTLRASSRLHDELFRRIL 956

  Fly   227 VQDIAFFDENRTGELVNRLTADVQ--DFKTSFKQFVSQGLRSAAQLIGGSISLF----MISPHMA 285
            ...:.|||...||.::||.:.|:.  |.:..|:         |...|...|.:|    ||:....
Human   957 RSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQ---------AEMFIQNVILVFFCVGMIAGVFP 1012

  Fly   286 AIALASVPCVVMFMT------YLGKKLRSLSKSSQAQAERATGVCEEALSNIRTVRSS---ACEY 341
            ...:|..|.|::|..      .|.::|:.|...:|:..........:.|:.|......   ...|
Human  1013 WFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRY 1077

  Fly   342 REMQLFEAETNEAARLAQKLGYGIAIFQGLTNFFLNTLVLSTLFMGGHLMSTESLSPGALMAFLV 406
            :|:    .:.|:|.                  |||.|..:..|.:...|:|...::...||..|:
Human  1078 QEL----LDDNQAP------------------FFLFTCAMRWLAVRLDLISIALITTTGLMIVLM 1120

  Fly   407 ASQGVQRSLAQGSILLGTMIRGMSAGSRVFEF---LSLQPQ-----VELLRGYI----------- 452
            ..| :..:.|..:|.....:.|:      |:|   |:.:.:     ||.:..||
Human  1121 HGQ-IPPAYAGLAISYAVQLTGL------FQFTVRLASETEARFTSVERINHYIKTLSLEAPARI 1178

  Fly   453 --------IPQERLHGEIRFENVSFAY----PMQPDHLVLKDFSLTLRPGQTVALVGASGSGKST 505
                    .|||   ||:.|||....|    |     ||||..|.|::|.:.:.:||.:|||||:
Human  1179 KNKAPSPDWPQE---GEVTFENAEMRYRENLP-----LVLKKVSFTIKPKEKIGIVGRTGSGKSS 1235

  Fly   506 IASLVERFYEPSAGNIKLDGYKLSDISPYWLRSNVLGFIEQQPVLFGTSILENI----RYGKPDA 566
            :...:.|..|.|.|.||:||.::|||....|||. |..|.|:||||..::..|:    :|
Human  1236 LGMALFRLVELSGGCIKIDGVRISDIGLADLRSK-LSIIPQEPVLFSGTVRSNLDPFNQY----- 1294

  Fly   567 GEEDVYAAARLSQSHDFVTALPDGYATHVGERGTQLSGGQRQRIAIARALLKNPRILILDEATSA 631
            .|:.::.|...:...:.:..||....:.|.|.|...|.|:||.:.||||||::.:||||||||:|
Human  1295 TEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAA 1359

  Fly   632 LDATSEAEVQKALDTVVQNRTTLVIAHRLSTIRNADLIVVLDQGRVVETGKHDELMGKRGLYFEL 696
            :|..::..:|:.:.....:.|.|.|||||.|:..:|.|:||.||:|||......|:......|
Human  1360 MDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRF-- 1422

  Fly   697 VRQQERRDIQEQVQAVEDVVAVK 719
                     .....|.|:.||||
Human  1423 ---------YAMFAAAENKVAVK 1436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	157/588 (27%)
		ABC_membrane	137..415	CDD:279056	53/267 (20%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	89/245 (36%)
ABCC5	NP_005679.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..41
		CFTR_protein	100..1430	CDD:273530	158/600 (26%)
		ABC_membrane	<271..447	CDD:294371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..538
		ABCC_MRP_domain1	577..759	CDD:213217
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	794..827
		ABC_membrane	863..1143	CDD:294371	56/288 (19%)
		ABCC_MRP_domain2	1191..1411	CDD:213211	89/230 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000