DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1824 and tap1

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	XP_002665053.1	Gene:	tap1 / 100333043	ZFINID:	ZDB-GENE-050517-43	Length:	731	Species:	Danio rerio

Alignment Length:	653	Identity:	220/653 - (33%)
Similarity:	341/653 - (52%)	Gaps:	57/653 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LVWG--------GGSLAIGLGARSWWAGHRGAIVHCEGSRLAIRKEE-EEEDTASEQHFDWKRLW 123
            ||||        .|...:||....|..       |.....|..:||. |::..||.|     ||.
Zfish   100 LVWGWHSWQGLVQGYFVLGLSLLIWKR-------HVPTILLTAKKERTEKKGKASLQ-----RLL 152

  Fly   124 TYLEPHLWELIGAVCAALIVAYINIRIPNLLGDLVNTLARYANTYVMDPINNSFVKDVSKPASNL 188
            .|::|............:|.:...:.||:..|.:.            |.|.|....:....|..:
Zfish   153 GYMKPFSGRFAAVFFFVVISSLGEMAIPHYTGKMT------------DWIMNEDEPEAFNHAITV 205

  Fly   189 LSLYMLQSGF-----TFMYIYLLSRVGEQMAAKMRQDLFTQIVVQDIAFFDENRTGELVNRLTAD 248
            ::|..:.|..     ..:|...:||:...:...    :|..::.|||||||:..||::|:|:|.|
Zfish   206 MTLMTIMSAVCEFVCDLIYNITMSRIHTSIQGL----VFQAVLKQDIAFFDKATTGDIVSRITTD 266

  Fly   249 VQDFKTSFKQFVSQGLRSAAQLIGGSISLFMISPHMAAIALASVPCVVMFMTYLGKKLRSLSKSS 313
            ......|..:.:|..:....::|....|:.|:|..:....|..:|.:.:.....|:..:.||...
Zfish   267 TNTMSESLSEKLSLLMWYFMRVIFLFGSMLMLSTRLCCFTLLGLPVIWIIPEIFGRFYQKLSAQV 331

  Fly   314 QAQAERATGVCEEALSNIRTVRSSACEYREMQLFE--AETNEAARLAQKLGYGIAIFQGLTNFFL 376
            |....:|..|..|..|:::||||.|.|..|.:.:.  .|...|....:...|.::.:   ||...
Zfish   332 QDSLAKANEVATETFSSMKTVRSFANEDGETERYRKCLEDTFALNKVEAAAYAVSTW---TNSMS 393

  Fly   377 N-TLVLSTLFMGGHLMSTESLSPGALMAFLVASQGVQRSLAQGSILLG---TMIRGMSAGSRVFE 437
            : .|.:|.|:.||.|::...:|.|.|::|::.......::   .:|:.   .:.:.:.|..::||
Zfish   394 SLALKVSILYYGGRLVTGSDVSSGDLVSFVLYELQFTSAV---EVLMSYWPHVKKAVGASEKIFE 455

  Fly   438 FLSLQPQVELLRGYIIPQERLHGEIRFENVSFAYPMQPDHLVLKDFSLTLRPGQTVALVGASGSG 502
            ::..:|.|. ..|.:.| :.|.|.::|.||:||||.:||..|||:.||.|:.|:..||||.||||
Zfish   456 YVDRKPDVP-PDGSLAP-KTLKGHVQFRNVTFAYPKRPDTDVLKNVSLELKAGKITALVGPSGSG 518

  Fly   503 KSTIASLVERFYEPSAGNIKLDGYKLSDISPYWLRSNVLGFIEQQPVLFGTSILENIRYGKPDAG 567
            |:|:.||:||||:|..|.|.||...|......:|...: ..:.|:||||..|:.|||:|||.:|.
Zfish   519 KTTVVSLLERFYQPQNGEILLDQKPLLSYKDQYLHEKI-SVVSQEPVLFARSVRENIKYGKENAT 582

  Fly   568 EEDVYAAARLSQSHDFVTALPDGYATHVGERGTQLSGGQRQRIAIARALLKNPRILILDEATSAL 632
            .|::||||||:.:|||:::||.||.|..||:|.|:||||:|||||||||::.|:||:||:|||:|
Zfish   583 NEEIYAAARLANAHDFISSLPKGYDTDAGEKGGQVSGGQKQRIAIARALIQKPQILVLDDATSSL 647

  Fly   633 DATSEAEVQKALDTVVQNRTTLVIAHRLSTIRNADLIVVLDQGRVVETGKHDELMGKRGLYFELV 697
            |..||..|..||...:|:.|.|:|:||||.:.|||.|:.|.:|.:||.|.|.:|:.|:|.|.|.|
Zfish   648 DTESEHRVYSALKKELQSCTVLLISHRLSGVENADHILFLREGELVEEGNHQQLLDKQGFYAEFV 712

  Fly   698 RQQ 700
            :||
Zfish   713 KQQ 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	204/593 (34%)
		ABC_membrane	137..415	CDD:279056	65/285 (23%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	123/237 (52%)
tap1	XP_002665053.1	3a01208	42..712	CDD:273363	217/648 (33%)
		ABC_membrane	166..433	CDD:279056	65/285 (23%)
		P-loop_NTPase	467..692	CDD:304359	117/226 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0058
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D684058at2759
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820