DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1824 and abcc1

DIOPT Version :9

Sequence 1:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	XP_001341895.3	Gene:	abcc1 / 100002010	ZFINID:	ZDB-GENE-050517-15	Length:	1518	Species:	Danio rerio

Alignment Length:	710	Identity:	182/710 - (25%)
Similarity:	311/710 - (43%)	Gaps:	117/710 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LPR--LQNA--ARLMRQHLRGTNAPQPPAIPPTNASRLLQTTRLLVWGGGSLAIGLGARSWWAGH 88
            :||  |:|.  |.|:||.....||        |.|.:..|.|.     ....|.....:|
Zfish   882 VPRKGLENGGPAALLRQSQISLNA--------TGAGKTTQKTE-----ANDDAAATKTKS----- 928

  Fly    89 RGAIVHCEGSRLAIRKEEEEEDTASEQHFDWKRLWTYLEPHLWELIGAVCAALIVAYINIRIPNL 153
                  .|.|||.      |.|.|:.........|.|::        |:...|.:..|.:...:.
Zfish   929 ------AEASRLT------EADKANTGRVKLSVFWEYMK--------AIGLPLSIFSIFLFFCHH 973

  Fly   154 LGDLVNTLARYANTYVMDPINNSFVKDVSKPASNL-LSLY----MLQSGFTFMYIYLLSRVGEQM 213
            |..|.:..  :.:.:..||:.|:     ::|...: |.:|    :.|....|.|...:| ||..:
Zfish   974 LSSLGSNY--WLSLWTDDPVVNN-----TQPKREMRLGVYGALGISQGIAVFCYSVSVS-VGGIL 1030

  Fly   214 AAK-MRQDLFTQIVVQDIAFFDENRTGELVNRLTADVQDFKTSFKQFVSQGLRSAAQLIGGSISL 277
            |:: :.|.:...::...::||:...:|.||||...:.....:.....:...:.|...:: ||.::
Zfish  1031 ASRYLHQTMLYNVLRSPMSFFERTPSGNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVL-GSCAV 1094

  Fly   278 FMISPHMAAIALASVPCVVMFMT--YLG-----KKLRSLSKSSQAQAERATGVCEEALSNIRTVR 335
            .:|:..:.||.:..:..:..|:.  |:.     |:|.|:|:|.      ......|.|.....:|
Zfish  1095 ILIATPLVAIIIPPLGLLYFFVQRFYVASSRQMKRLESVSRSP------VYTHFNETLLGTSVIR 1153

  Fly   336 SSACEYREMQLFEAETNEAARLAQKLGYGIAIFQGLT---------NFFLNTLV-LSTLFMGGHL 390
            :    :.|.|.|..|::......||     |.|..:.         .|..|.:| .:.||.   :
Zfish  1154 A----FGEQQRFIKESDGRVDHNQK-----AYFPSIVANRWLAVRLEFVGNCIVTFAALFA---V 1206

  Fly   391 MSTESLSPGALMAFLVASQGVQRSLA-QGSILLGTMIRGMS-------AGSRVFEFLSLQPQVE- 446
            |:..:||||.:        |:..|.| |.:..|..::|..|       |..||.|:...:.:.|
Zfish  1207 MARNNLSPGIM--------GLSISYALQVTASLNWLVRMSSELETNIVAVERVKEYGDTEKEAEW 1263

  Fly   447 -LLRGYIIPQERLHGEIRFENVSFAYPMQPDHLVLKDFSLTLRPGQTVALVGASGSGKSTIASLV 510
             |....:.|.....|.|........| .:...|.:.|.|:.:..|:.|.:||.:|:|||::...:
Zfish  1264 KLENSNLPPGWPTAGHIEIHKFGLRY-REDLELAICDISVNIAGGEKVGIVGRTGAGKSSLTLGL 1327

  Fly   511 ERFYEPSAGNIKLDGYKLSDISPYWLRSNVLGFIEQQPVLFGTSILENIRYGKPDAG--EEDVYA 573
            .|..|.:.|.|::||..::|:..:.|||.:. .|.|.||||..|:..|:   .|..|  :|:|:.
Zfish  1328 FRIIEAAEGEIRIDGVNIADLGLHELRSRIT-IIPQDPVLFSGSLRMNL---DPFDGYTDEEVWR 1388

  Fly   574 AARLSQSHDFVTALPDGYATHVGERGTQLSGGQRQRIAIARALLKNPRILILDEATSALDATSEA 638
            :..|:....||:.|||.......|.|..||.||||.:.:|||||:..:||:|||||:|:|..::.
Zfish  1389 SLELAHLKTFVSGLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKILVLDEATAAVDLETDN 1453

  Fly   639 EVQKALDTVVQNRTTLVIAHRLSTIRNADLIVVLDQGRVVETGKHDELMGKRGLYFELVR 698
            .:|..:.|..::.|.|.|||||:||.:...::|||:|::.|......|:.|:|:::::.:
Zfish  1454 LIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGQMAEFDSPSNLIAKKGIFYKMAK 1513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	159/615 (26%)
		ABC_membrane	137..415	CDD:279056	60/300 (20%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	82/239 (34%)
abcc1	XP_001341895.3	MRP_assoc_pro	7..1517	CDD:188098	182/710 (26%)
		ABC_membrane	331..595	CDD:279056
		ABCC_MRP_domain1	641..842	CDD:213217
		ABC_membrane	966..1231	CDD:279056	62/299 (21%)
		ABCC_MRP_domain2	1278..1498	CDD:213211	80/224 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000