DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LIMK1 and AT5G38210

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_001331338.1	Gene:	AT5G38210 / 833803	AraportID:	AT5G38210	Length:	698	Species:	Arabidopsis thaliana

Alignment Length:	739	Identity:	168/739 - (22%)
Similarity:	280/739 - (37%)	Gaps:	190/739 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 HPECFCCTACGSFIGEGESYA---LVERSKLYCGQCYGKRSCQPADAKARITTA-------GKPM 169
            |..|.....||:   :.|.|.   :.||.:  ||....:.:|....|:..::|.       ....
plant    35 HKHCSPRFKCGN---QSELYYPFWISERKE--CGHPDFEVNCSGDFAELTVSTVKFQILEMNYEF 94

  Fly   170 HSIRLVEI----------PKDA---------TPGLRVDGVALDDGCPTVRITDLFCNFFLWLTSM 215
            ..|||..:          |.:|         :|..::.....|  |.:.  .|:..|.::...:.
plant    95 EIIRLARMDYRNNLCPQHPANASINHDVLPFSPDTKLSTFYHD--CQST--VDVHPNDYIKQLNC 155

  Fly   216 AEQCCGAPYRIDVNLTNLHIGDRI--------LEVNGTPVSDSSVEQIDKLIRSNEKMLQLTVEH 272
            .:...|..|.:.   ::.|.|||.        .|....|||.|:::.::| .:|.|.|.:...|.
plant   156 EDYIGGKSYFVS---SSSHSGDRATLAALSASCEGVDIPVSRSALKTVEK-NQSLEAMKKAIDEG 216

  Fly   273 DPVQVCRSCSQADI--------QRAMS----------ASTLILPL--STSASSVEVGRERLYKTP 317
            ..:.....|||..|        ||..:          .||....:  .|.|...:.|:..:....
plant   217 FELGFNNECSQCAISGGACGFDQRLKAFVCYCADEPHESTCYSEIVKKTHAGLSKKGKIGIGFAS 281

  Fly   318 GEQGT-------------KARKL-RQATN--ASTTIPPAAGATAMTQLKEKERCSSLSKLLDEQH 366
            |..|.             :.:|| .|.||  .|||.|.::..|    :......:::|
plant   282 GFLGATLIGGCLLCIFIRRRKKLATQYTNKGLSTTTPYSSNYT----MSNTPTSTTIS------- 335

  Fly   367 QAQQHSAHPQLYDLSRTQSCRVVQ--KPQRIFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVL 429
             ...||..|.:.:|........:|  ..:.:..||: ...::||:|.||.|:..| .:.|..:.:
plant   336 -GSNHSLVPSISNLGNGSVYSGIQVFSYEELEEATE-NFSKELGDGGFGTVYYGT-LKDGRAVAV 397

  Fly   430 KELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYK-DKKLHMVTEYVAGGCLKELIH-DPAQ 492
            |.|.....:....|..|:.:|:.|.|.:::...|...: .::|.:|.||::.|.|.|.:| :.||
plant   398 KRLFERSLKRVEQFKNEIDILKSLKHPNLVILYGCTTRHSRELLLVYEYISNGTLAEHLHGNQAQ 462

  Fly   493 VLP--WPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGLAR--SVDAPRLP 553
            ..|  ||.|:::|.:.|..:||||:..|||||:.:.|.|:..:..|.||||||:|  .:|...:
plant   463 SRPICWPARLQIAIETASALSYLHASGIIHRDVKTTNILLDSNYQVKVADFGLSRLFPMDQTHI- 526

  Fly   554 SGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSF 618
                          |.||.                     |.|.::.||..:..:.:||.||:||
plant   527 --------------STAPQ---------------------GTPGYVDPEYYQCYRLNEKSDVYSF 556

  Fly   619 GIMLCEIIGRVEADPDFMPRNSDFSLNQ-----------QEFREKFCAQCPEPFVK--------V 664
            |::|.|:|...|| .|......|.:|..           .|..:.......:|.||        :
plant   557 GVVLSELISSKEA-VDITRHRHDINLANMAISKIQNDAVHELADLSLGFARDPSVKKMMSSVAEL 620

  Fly   665 AFVCCDLNPDMRPCFETLHVWLQRLADDLAADRVPPERLLHEIETFQEWYASSEDALSPTSQRSL 729
            ||.|.....|:||..:.:...|:.:..|..:|                    |:|.:   .:..:
plant   621 AFRCLQQERDVRPSMDEIVEVLRVIQKDGISD--------------------SKDVV---VEIDV 662

  Fly   730 NNLDE--LVKSAVDSEISPVEKEK 751
            |..|:  |:|..|...:|| |.:|
plant   663 NGGDDVGLLKHGVPPPLSP-ETDK 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751	10/35 (29%)
		PDZ_signaling	172..271	CDD:238492	25/125 (20%)
		STKc_LIMK	407..693	CDD:271056	85/310 (27%)
AT5G38210	NP_001331338.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000