DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LIMK1 and AT4G31230

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_194851.2	Gene:	AT4G31230 / 829250	AraportID:	AT4G31230	Length:	764	Species:	Arabidopsis thaliana

Alignment Length:	582	Identity:	118/582 - (20%)
Similarity:	217/582 - (37%)	Gaps:	155/582 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 GQCYGKRSCQPADAKARITTAGKPMHSIRLVEIPKDATPGLRVDGVALDDGCPTVRITDLFCNFF 209
            |:.||:.|.  .|::....::|:               |.:..:..:|.|.....|......||
plant   245 GRSYGELSI--PDSEISFNSSGR---------------PSIERNSPSLYDNSDPNRTPPRLSNF- 291

  Fly   210 LWLTSMAEQCCGAPYRIDVNLTNLHIGDRILEVNG-TPVSDSSVEQIDKLIRSNEKMLQLTVEHD 273
                |..:.|         :..::..|.|.::::. |..|..|.|        ||:....:...|
plant   292 ----SDVDYC---------SFESMTFGRRSMDLSSPTAFSTGSFE--------NERFSSASQGGD 335

  Fly   274 PVQVCRSCSQADIQRAM----SASTLILPLSTSASSVE---VGRERLYKTP--GEQGTKARKLRQ 329
            .|:......:.::::.|    :|....|.....|:.::   :..||.::..  .|:...|...::
plant   336 DVEAEMRRLKLELKQTMEMYSTACKEALTAKHKATELQRWKLAEERKFEEAKLAEEAALAIAEKE 400

  Fly   330 ATNASTTIPPAAGATAMTQLKEKERCSSLSKLLDEQHQAQQHSAHPQLYDLSRTQSCRVVQKPQR 394
            ...:...:..|..|..:..::.::|..:.:|.|.|..              :||::...:.|..|
plant   401 KAKSKAAMEAAEAAQRIADIESRKRVDAETKALKESE--------------ARTKAVNALAKDVR 451

  Fly   395 --------IFRATDLVIGE-KLGEGFFGKVFK--VTHRQSGEVMVLKELHRADEEAQRNFIKEVA 448
                    |..||:....: |:|||.:|.|:|  :.|..    :.:|.|.....:.:..|.|||.
plant   452 YRKYSIEEIEDATEFFDDKYKIGEGSYGPVYKCYLDHTP----VAVKALRPDAAQGRSQFQKEVE 512

  Fly   449 VLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELI----HDPAQVLPWPQRVRLARDIACG 509
            ||..:.|.:::..:|...:...|  |.|::|.|.|::.:    ..||  |.|..|.|:|.:|...
plant   513 VLCSIRHPNMVLLLGACPECGCL--VYEFMANGSLEDRLFRQGDSPA--LSWQTRFRIAAEIGTV 573

  Fly   510 MSYLHSMN---IIHRDLNSMNCLVREDRSVI--VADFGLARSVDAPRLPSGNMTPGGYGSGANSD 569
            :.:||...   ::||||...|.|:  ||:.:  :||.||||.|
plant   574 LLFLHQTKPEPLVHRDLKPANILL--DRNFVSKLADVGLARLV---------------------- 614

  Fly   570 APMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEII-------- 626
             |.|.:.|:      .:....:..|...::.||..:......|.|::|.|||..::|
plant   615 -PPSVANTV------TQYHMTSTAGTFCYIDPEYQQTGMLGVKSDIYSLGIMFLQLITGKPPMGL 672

  Fly   627 ----------GRVEADPDFM-PRNSDFSLNQQEFREKFCAQCPEPFVKVAFVCCDLNPDMRP 677
                      |.::   |.: |..||:.:..           ...|.|:|..|.::....||
plant   673 THYVERALEKGNLK---DLLDPAVSDWPVED-----------TTEFAKLALKCAEIRRKDRP 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751	1/2 (50%)
		PDZ_signaling	172..271	CDD:238492	16/99 (16%)
		STKc_LIMK	407..693	CDD:271056	72/301 (24%)
AT4G31230	NP_194851.2	STK_N	17..172	CDD:238947
		Pkinase	467..720	CDD:278497	71/305 (23%)
		STKc_IRAK	473..733	CDD:270968	72/301 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000