DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LIMK1 and AT4G27290

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_001329181.1	Gene:	AT4G27290 / 828837	AraportID:	AT4G27290	Length:	829	Species:	Arabidopsis thaliana

Alignment Length:	664	Identity:	147/664 - (22%)
Similarity:	237/664 - (35%)	Gaps:	220/664 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 HLHNWYFEREGLLYCREDYYGRFGDACQQCMAVITGPVMVAGEH-----KFHPECFCCTACGSFI 128
            :|.:|.|           |.....|:|.|        ..:.|.:     ...|.|.|..   .|:
plant   276 NLQSWNF-----------YLSAMMDSCDQ--------YTLCGSYGSCNINESPACRCLK---GFV 318

  Fly   129 GE-------GE-SYALVERSKLYCGQCYGKRSCQPADAKARITTAGKPMHSIRLVEIPKDATPGL 185
            .:       |: |...|.|.||.||:  |:..                     .::|.|...|..
plant   319 AKTPQAWVAGDWSEGCVRRVKLDCGK--GEDG---------------------FLKISKLKLPDT 360

  Fly   186 RVD----GVALDDGCPTVRITDLFCNFF-------------LWLTSMAEQCCGAPYRIDVNLTNL 233
            |..    .:.|:: |..|.:.:..|:.:             ||...:          ||:...|.
plant   361 RTSWYDKNMDLNE-CKKVCLRNCTCSAYSPFDIRDGGKGCILWFGDL----------IDIREYNE 414

  Fly   234 HIGDRILEVNGTPVSDSSVEQIDKLIRSNEKMLQLTVEHDPVQVCRSCSQADIQRAMSASTLILP 298
            :..|..:.:..:.:.:.::..:...||    |:.:.|                   :|.:..:..
plant   415 NGQDLYVRLASSEIDEYNIHYVKGKIR----MILIIV-------------------LSTALFLFC 456

  Fly   299 LSTSASSVEVGRERLYKTPGEQGTKARKLRQATNASTTIPPAAGATAMTQLKEKERCSSLSKLLD 363
            |....:...:.:::|                             ||..|..:|..|.||
plant   457 LCIGLTVFNMKKKKL-----------------------------ATKETLQRESSRVSS------ 486

  Fly   364 EQHQAQQHSAHPQLYDLSRTQSCRVVQKPQRIFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMV 428
             :.|.::....|.| ||.      .|.:....|.|     |.|||:|.||.|:|.| ...|:.:.
plant   487 -RKQEEEDLELPFL-DLD------TVSEATSGFSA-----GNKLGQGGFGPVYKGT-LACGQEVA 537

  Fly   429 LKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELIHDP--A 491
            :|.|.|...:....|..|:.::..|.||:::|.:|....:::..::.||.....|...|.|.  .
plant   538 VKRLSRTSRQGVEEFKNEIKLIAKLQHRNLVKILGYCVDEEERMLIYEYQPNKSLDSFIFDKERR 602

  Fly   492 QVLPWPQRVRLARDIACGMSYLHS---MNIIHRDLNSMNCLVREDRSVIVADFGLARSVDAPRLP 553
            :.|.||:||.:.:.||.||.|||.   :.||||||.:.|.|:..|.:..::||||||
plant   603 RELDWPKRVEIIKGIARGMLYLHEDSRLRIIHRDLKASNVLLDSDMNAKISDFGLAR-------- 659

  Fly   554 SGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSF 618
                |.||..:.||         |.|            |||...:|:||......:..|.|||||
plant   660 ----TLGGDETEAN---------TTR------------VVGTYGYMSPEYQIDGYFSLKSDVFSF 699

  Fly   619 GIMLCEII-GRVEADPDFMPRNSDFSLN-----QQEFRE------------KFCAQCPEPF--VK 663
            |:::.||: ||  .:..|  ||.:..||     .::|.|            :.|....|..  :.
plant   700 GVLVLEIVSGR--RNRGF--RNEEHKLNLLGHAWRQFLEDKAYEIIDEAVNESCTDISEVLRVIH 760

  Fly   664 VAFVCCDLNPDMRP 677
            :..:|...:|..||
plant   761 IGLLCVQQDPKDRP 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750	3/18 (17%)
		LIM2_LIMK	95..148	CDD:188751	15/65 (23%)
		PDZ_signaling	172..271	CDD:238492	17/115 (15%)
		STKc_LIMK	407..693	CDD:271056	88/296 (30%)
AT4G27290	NP_001329181.1	B_lectin	72..180	CDD:396163
		S_locus_glycop	212..321	CDD:395761	12/66 (18%)
		PAN_2	342..409	CDD:400531	14/100 (14%)
		STKc_IRAK	517..780	CDD:270968	88/296 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000