DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LIMK1 and limk1

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_001072900.1	Gene:	limk1 / 780362	XenbaseID:	XB-GENE-1011258	Length:	615	Species:	Xenopus tropicalis

Alignment Length:	710	Identity:	305/710 - (42%)
Similarity:	400/710 - (56%)	Gaps:	129/710 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GPVSGGHSPLCAHCRGQLLPHPEEPIVMALGQQWHCDCFRCSVCEGHLHNWYFEREGLLYCREDY 87
            |...|...|:||.| ||.:  .:...:.||...||.||||||.|...|.:.|:|::|.|:|::.|
Frog    16 GEEEGNGLPVCASC-GQSI--YDGCYLQALALDWHSDCFRCSDCGVSLSHRYYEKDGRLFCKKHY 77

  Fly    88 YGRFGDACQQCMAVIT-GPVMVAGEHKFHPECFCCTACGSFIGEGESYALVERSKLYCGQCYGKR 151
            :.|||..||.|...|| |.||||||||:|||||.|:.|.::||:.|:||||||||||||.||.:.
Frog    78 WARFGGMCQGCSENITKGLVMVAGEHKYHPECFMCSRCKAYIGDVETYALVERSKLYCGPCYYQF 142

  Fly   152 SCQPADAKARITTAG-KPMHSIRLVEIPKDATPGLRVDGVALDDGCP----TVRITDLFCNFFLW 211
            |..|.     |.:.| :..|::.||.:|  |:.|.|...|::...|.    |||::.|
Frog   143 SVTPV-----IDSPGSRSPHTVTLVSLP--ASDGKRGLSVSITPSCAEHSHTVRVSQL------- 193

  Fly   212 LTSMAEQCCGAPYRIDVNLTNLHIGDRILEVNGTPVSDSSVEQIDKLIRSNEKMLQLTVEHDPVQ 276
                 :..|.:|   |:..| :||||||||:||||:....:::||.||:...::||||:||||.:
Frog   194 -----DTDCLSP---DIQST-IHIGDRILEINGTPIRSVPLDEIDVLIQETSRLLQLTIEHDPHE 249

  Fly   277 ---VCRSCSQADIQRAMSASTLILPLSTSASSVEVGRERLYKTPGEQGTKARKLRQATNASTTIP 338
               :...|::..::|..       |:..|.|        :.::||..
Frog   250 TPTLPSPCTEITVRRQR-------PIMRSCS--------IDRSPGSS------------------ 281

  Fly   339 PAAGATAMTQLKEKERCSSLSKLLDEQHQAQQHSAHPQLYDLSRTQSCRVVQKPQRIFRATDLVI 403
             ..|:.:         ||.                    .|:||::|.|.|....||||.:||:.
Frog   282 -CVGSPS---------CSR--------------------RDMSRSESVRTVTGVHRIFRPSDLMP 316

  Fly   404 GEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKD 468
            ||.||.|.||:..|||||.:|||||:|||.|.|||.||.|:|||.|:|.|:|.:|||||||||||
Frog   317 GEVLGRGCFGQAIKVTHRVTGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKD 381

  Fly   469 KKLHMVTEYVAGGCLKELIHDPAQVLPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVRED 533
            |:|:.:|||:.||.|:.:|.......||.|||..|||||.||:||||||||||||||.|||||||
Frog   382 KRLNFITEYIPGGTLRRVIKSMDAHYPWNQRVSFARDIAAGMTYLHSMNIIHRDLNSHNCLVRED 446

  Fly   534 RSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYW 598
            .|::||||||||.|                    :|.        .|...:.||:||||||||||
Frog   447 GSLVVADFGLARLV--------------------TDE--------TRDLRKDRRKRYTVVGNPYW 483

  Fly   599 MAPEMMKGLKYDEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQQEFREKFC-AQCPEPFV 662
            |||||:.|..|||.|||||.||::|||||||.||||::||..||.||.:.|.::|| ..||..|.
Frog   484 MAPEMINGRSYDESVDVFSCGIVICEIIGRVNADPDYLPRTMDFGLNVRAFLDRFCPPNCPPGFF 548

  Fly   663 KVAFVCCDLNPDMRPCFETLHVWLQRLADDLAADRVPPERLLHEIE-TFQEWYASSEDAL 721
            ..|.:||||:|:.||.|..|.:||..|...|.. ::|....|.::| .|.|.|...:..|
Frog   549 PSAVLCCDLDPEKRPRFSQLQLWLDSLLRHLNL-QLPLSSHLEQLERNFWENYRRGDSTL 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750	22/54 (41%)
		LIM2_LIMK	95..148	CDD:188751	36/53 (68%)
		PDZ_signaling	172..271	CDD:238492	36/102 (35%)
		STKc_LIMK	407..693	CDD:271056	161/286 (56%)
limk1	NP_001072900.1	LIM1_LIMK1	5..78	CDD:188846	25/64 (39%)
		LIM2_LIMK	85..139	CDD:188751	36/53 (68%)
		PDZ	161..244	CDD:278991	36/100 (36%)
		PKc_like	320..579	CDD:328722	161/286 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	309	1.000	Domainoid score	I1325
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1738
Inparanoid	1	1.050	537	1.000	Inparanoid score	I1167
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119463at33208
OrthoFinder	1	1.000	-	-		FOG0003618
OrthoInspector	1	1.000	-	-		otm48706
Panther	1	1.100	-	-	O	PTHR46485
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2495
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160