Protein Alignment LIMK1 and tesk2

DIOPT Version :10

• Sequence 1: NP_511139.2
• Gene: LIMK1 / 32207
• FlyBaseID: FBgn0283712
• Length: 1257
• Species: Drosophila melanogaster
• Sequence 2: XP_012816769.2
• Gene: tesk2 / 779799
• XenbaseID: XB-GENE-954759
• Length: 664
• Species: Xenopus tropicalis
• Alignment Length: 747
• Identity: 208/747 - (27%)
• Similarity: 317/747 - (42%)
• Gaps: 211/747 - (28%)

  Fly   394 RIFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHV 458
            |:.|..|... ||:|.|||.:||||.||.|.:||.||....:...|  |.:|||.::..|.|.::
 Frog    48 RLTRLDDFTC-EKIGSGFFSEVFKVRHRTSDQVMALKMNKLSSNRA--NMLKEVQLMNRLSHPNI 109

  Fly   459 LKFIGVLYKDKKLHMVTEYVAGGCLKELIHDPAQVLPWPQRVRLARDIACGMSYLHSMNIIHRDL 523
            |:|:||.....:||.:|||:..|.|::|: |..|.|.|..||:||.|||.|::||||..|.||||
 Frog   110 LRFMGVCVHQGQLHALTEYINSGNLEQLL-DSNQHLTWTVRVKLALDIALGLAYLHSKGIFHRDL 173

  Fly   524 NSMNCLVREDR---SVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQ 585
            .|.|||::.|.   |.:|||||||.     ::|.       |..|:
 Frog   174 TSKNCLIKSDESGYSAVVADFGLAE-----KIPD-------YSEGS------------------- 207

  Fly   586 RRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQQEFR 650
              ::..|||:|||||||:::...||||.||||:||:|||||.|::||||::||..:|.|:...|
 Frog   208 --EKLAVVGSPYWMAPEVLRDEPYDEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDGF- 269

  Fly   651 EKFCAQCPEPFVKVAFVCCDLNPDMRPCFETLHVWLQRLADDLAADRVPPERLLHEIETFQEWYA 715
            :.....||..|:::.|.||:::|.:||.|..:...|:.:.:.|..:....||
 Frog   270 QHMVGDCPPDFLQLTFNCCNMDPKLRPSFIDIAKQLENILNRLRNEEAERER------------- 321

  Fly   716 SSEDALSPTSQRSLNNLDELVKSAVDSEISPVEKEKENMVIKPQD--IP-KSPHLGKDFSPSGER 777
                     ...|.||::....|.........:..|..:.:.|||  || |||...::.:.|  |
 Frog   322 ---------KDLSENNIEPKPISLAKGPNDKCQGVKRLISMVPQDDKIPQKSPRPRRNITLS--R 375

  Fly   778 LRDSMRARRRQRFLGAQEERRNLTPDTESKERALKKALKKCRPFGERGYLVDLRAGAELQLEDVR 842
            .:..:.||:..|.:..|:.  ..||.        |.|::|..||..|              ||::
 Frog   376 SQSDIFARKPLRKVNVQDP--FYTPS--------KGAVRKVNPFSAR--------------EDLK 416

  Fly   843 DLNTYSDVDSSCDTSLNYHDVNNLPAAQEDENTVKPGKEELLEESTNKPSNQESQHHRLAIDDM- 906
            ....:.|:.|....| :..|:::            |.::..|...|:      .|..:|...|:
 Frog   417 GRIKFFDMPSKSVIS-HVFDLHS------------PKRDGSLAAGTS------GQIRQLLSQDIV 462

  Fly   907 ------RTRLNQCRS----------------------KFEHLE---EASRRNFNQSQHSMKNFFK 940
                  |.|   |||                      ||:..:   |..::..:..::|:::.
 Frog   463 DFSIIPRRR---CRSLPVSPELLRKDCTSSGLSCTVGKFDPAQLGSEVRQKLLSSVKYSVQDI-- 522

  Fly   941 TPPVALKMFQRLE--------HEAAALNGGNN-CPPPPPRTQR-----INQTPIFGRKNPPVAIV 991
             ||...:..:.|:        .:|......|. |   |.||:.     .||..:..:|:   |..
 Frog   523 -PPFRPRSPEYLQANDEDMDCTDATFTQEANGFC---PGRTENKVQAYYNQLLVSNKKH---AHC 580

  Fly   992 GQKLQHAESLE----DLASSGVAKQLATPAPKRSKATATTKGGQSSNPPLFLPPSLNISVALNSN 1052
            .||..::.|.|    ||.||..|.::....                        |.|:|.||:::
 Frog   581 SQKSLNSYSEEENSFDLFSSSEAMEIEEET------------------------SQNLSTALSAS 621

  Fly  1053 ----------GNVT----TTTNTNSSCPPSAS 1070
                      |.||    ..|..:|...||.|
 Frog   622 SISFSSPTRVGGVTLLPLENTVADSKDSPSLS 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751
		PDZ_LIMK-like	169..274	CDD:467236
		STKc_LIMK	407..693	CDD:271056	117/288 (41%)
tesk2	XP_012816769.2	PKc_TESK	60..312	CDD:271057	117/288 (41%)