DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LIMK1 and braf

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	XP_031754388.1	Gene:	braf / 779570	XenbaseID:	XB-GENE-1014202	Length:	963	Species:	Xenopus tropicalis

Alignment Length:	718	Identity:	172/718 - (23%)
Similarity:	257/718 - (35%)	Gaps:	193/718 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 HNW----YFEREGLLYCREDYYGRFGDACQQCMAVITGPVMVAGEHKFHPECFCCTACGSFIGEG 131
            ||:    :|......:||:..:..|  .||.|            .:|||..  |.|.........
Frog   239 HNFVRKTFFTLAFCDFCRKLLFQGF--RCQTC------------GYKFHQR--CSTEVPLMCVNY 287

  Fly   132 ESYALVERSKLYCGQCYGKRSCQPADAKARITTAGKPMHSIRLVEIPKDATPGLRVDGVALDDGC 196
            :...|:..||.:......:... |.:..|....:..|       ..|.|||..|.:...:.....
Frog   288 DRLDLLFVSKFFEHHPISQEEA-PFEEVAPAAESSTP-------PPPPDATGPLCLPSTSPSKSI 344

  Fly   197 PTVRITDLFCNFFLWLTSMAEQCCGAPYRIDVNLTNLHIGDRILEVNGTPVSDSSVE--QIDKLI 259
            |..:                      |:|.|.:..| ..|.|....:...|..:::|  .||.||
Frog   345 PIPQ----------------------PFRPDEDHRN-QFGQRDRSSSAPNVHINTIEPVNIDDLI 386

  Fly   260 RSNEKMLQLTVEHDPVQVCRSCSQADIQRAMSASTLILP--LSTSASSVEVGRERLYKTPGEQGT 322
            |  ::.||.:.....||..| |.:....|..|.....||  :.....|..|.|.   .|||...|
Frog   387 R--DQGLQCSEGAPSVQPTR-CHRKYHSRDPSPLLHTLPSEIVFDFESDPVCRG---STPGLSAT 445

  Fly   323 KARKLRQATNASTTIPPAAGATAMTQLK--------EKERCSSLSKLLDEQHQAQQHSAHPQLYD 379
                           |||:...::|.:|        ::||.||.|...|..          ::..
Frog   446 ---------------PPASLPGSLTNVKALQKSPGQQRERKSSSSSTEDRS----------RMKT 485

  Fly   380 LSRTQSCRVVQKPQRIFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQ--RN 442
            |.|..|....:.|.     ..:.:|:::|.|.||.|:|  .:..|:|.| |.|:......|  :.
Frog   486 LGRRDSSDDWEIPD-----GQITVGQRIGSGSFGTVYK--GKWHGDVAV-KMLNVTAPTPQQLQA 542

  Fly   443 FIKEVAVLRLLDHRHVLKFIGVLYKDK-KLHMVTEYVAGGCLKELIHDPAQVLPWPQRVRLARDI 506
            |..||.|||...|.::|.|:|  |..| :|.:||::..|..|...:|.........:.:.:||..
Frog   543 FKNEVGVLRKTRHVNILLFMG--YSTKPQLRLVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQT 605

  Fly   507 ACGMSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAP 571
            |.||.|||:.:||||||.|.|..:.||.:|.:.|||||             |.....||::....
Frog   606 AQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLA-------------TVKSRWSGSHQFEQ 657

  Fly   572 MSPSGTLRRSKSRQRRQRYTVVGNPYWMAPE---MMKGLKYDEKVDVFSFGIMLCEI-------- 625
            :|                    |:..|||||   |.....|..:.||::|||:|.|:
Frog   658 LS--------------------GSILWMAPEVIRMQDNNPYSFQSDVYAFGIVLYELMTGQLPYS 702

  Fly   626 -----------IGRVEADPDFMPRNSDFSLNQQEFREKFCAQCPEPFVKVAFVCCDLNPDMRPCF 679
                       :||....|||               .|..:.||:...::...|.....|.||.|
Frog   703 NINNRDQIIFMVGRGYLSPDF---------------SKVRSNCPKAMKRLMADCLKKKRDERPLF 752

  Fly   680 ETLHVWLQRLADDL-----AADRVPPERLLHEIETFQEWYASSEDA--------LSPTSQRSLNN 731
            ..:...::.||..|     :|......|...:.|.|..:..:|...        :||   |.:||
Frog   753 PQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYTCASPKTPIQAGGYEISP---RWVNN 814

  Fly   732 LDE 734
            .:|
Frog   815 FNE 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750	5/20 (25%)
		LIM2_LIMK	95..148	CDD:188751	11/52 (21%)
		PDZ_signaling	172..271	CDD:238492	21/100 (21%)
		STKc_LIMK	407..693	CDD:271056	88/310 (28%)
braf	XP_031754388.1	RBD_BRAF	158..236	CDD:340654
		C1	234..293	CDD:412127	14/69 (20%)
		STKc_Raf	508..760	CDD:270964	86/304 (28%)
		DERM	815..962	CDD:405404	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000