Protein Alignment LIMK1 and braf

DIOPT Version :10

• Sequence 1: NP_511139.2
• Gene: LIMK1 / 32207
• FlyBaseID: FBgn0283712
• Length: 1257
• Species: Drosophila melanogaster
• Sequence 2: XP_031754388.1
• Gene: braf / 779570
• XenbaseID: XB-GENE-1014202
• Length: 963
• Species: Xenopus tropicalis
• Alignment Length: 718
• Identity: 172/718 - (23%)
• Similarity: 257/718 - (35%)
• Gaps: 193/718 - (26%)

  Fly    71 HNW----YFEREGLLYCREDYYGRFGDACQQCMAVITGPVMVAGEHKFHPECFCCTACGSFIGEG 131
            ||:    :|......:||:..:..|  .||.|            .:|||..  |.|.........
 Frog   239 HNFVRKTFFTLAFCDFCRKLLFQGF--RCQTC------------GYKFHQR--CSTEVPLMCVNY 287

  Fly   132 ESYALVERSKLYCGQCYGKRSCQPADAKARITTAGKPMHSIRLVEIPKDATPGLRVDGVALDDGC 196
            :...|:..||.:......:... |.:..|....:..|       ..|.|||..|.:...:.....
 Frog   288 DRLDLLFVSKFFEHHPISQEEA-PFEEVAPAAESSTP-------PPPPDATGPLCLPSTSPSKSI 344

  Fly   197 PTVRITDLFCNFFLWLTSMAEQCCGAPYRIDVNLTNLHIGDRILEVNGTPVSDSSVE--QIDKLI 259
            |..:                      |:|.|.:..| ..|.|....:...|..:::|  .||.||
 Frog   345 PIPQ----------------------PFRPDEDHRN-QFGQRDRSSSAPNVHINTIEPVNIDDLI 386

  Fly   260 RSNEKMLQLTVEHDPVQVCRSCSQADIQRAMSASTLILP--LSTSASSVEVGRERLYKTPGEQGT 322
            |  ::.||.:.....||..| |.:....|..|.....||  :.....|..|.|.   .|||...|
 Frog   387 R--DQGLQCSEGAPSVQPTR-CHRKYHSRDPSPLLHTLPSEIVFDFESDPVCRG---STPGLSAT 445

  Fly   323 KARKLRQATNASTTIPPAAGATAMTQLK--------EKERCSSLSKLLDEQHQAQQHSAHPQLYD 379
                           |||:...::|.:|        ::||.||.|...|..          ::..
 Frog   446 ---------------PPASLPGSLTNVKALQKSPGQQRERKSSSSSTEDRS----------RMKT 485

  Fly   380 LSRTQSCRVVQKPQRIFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQ--RN 442
            |.|..|....:.|.     ..:.:|:::|.|.||.|:|  .:..|:|.| |.|:......|  :.
 Frog   486 LGRRDSSDDWEIPD-----GQITVGQRIGSGSFGTVYK--GKWHGDVAV-KMLNVTAPTPQQLQA 542

  Fly   443 FIKEVAVLRLLDHRHVLKFIGVLYKDK-KLHMVTEYVAGGCLKELIHDPAQVLPWPQRVRLARDI 506
            |..||.|||...|.::|.|:|  |..| :|.:||::..|..|...:|.........:.:.:||..
 Frog   543 FKNEVGVLRKTRHVNILLFMG--YSTKPQLRLVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQT 605

  Fly   507 ACGMSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAP 571
            |.||.|||:.:||||||.|.|..:.||.:|.:.|||||             |.....||::....
 Frog   606 AQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLA-------------TVKSRWSGSHQFEQ 657

  Fly   572 MSPSGTLRRSKSRQRRQRYTVVGNPYWMAPE---MMKGLKYDEKVDVFSFGIMLCEI-------- 625
            :|                    |:..|||||   |.....|..:.||::|||:|.|:
 Frog   658 LS--------------------GSILWMAPEVIRMQDNNPYSFQSDVYAFGIVLYELMTGQLPYS 702

  Fly   626 -----------IGRVEADPDFMPRNSDFSLNQQEFREKFCAQCPEPFVKVAFVCCDLNPDMRPCF 679
                       :||....|||               .|..:.||:...::...|.....|.||.|
 Frog   703 NINNRDQIIFMVGRGYLSPDF---------------SKVRSNCPKAMKRLMADCLKKKRDERPLF 752

  Fly   680 ETLHVWLQRLADDL-----AADRVPPERLLHEIETFQEWYASSEDA--------LSPTSQRSLNN 731
            ..:...::.||..|     :|......|...:.|.|..:..:|...        :||   |.:||
 Frog   753 PQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYTCASPKTPIQAGGYEISP---RWVNN 814

  Fly   732 LDE 734
            .:|
 Frog   815 FNE 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750	5/20 (25%)
		LIM2_LIMK	95..148	CDD:188751	11/52 (21%)
		PDZ_LIMK-like	169..274	CDD:467236	21/106 (20%)
		STKc_LIMK	407..693	CDD:271056	88/310 (28%)
braf	XP_031754388.1	RBD_BRAF	158..236	CDD:340654
		C1	234..293	CDD:412127	14/69 (20%)
		STKc_Raf	508..760	CDD:270964	86/304 (28%)
		DERM	813..962	CDD:464273	3/5 (60%)