Protein Alignment LIMK1 and limk1a

DIOPT Version :10

• Sequence 1: NP_511139.2
• Gene: LIMK1 / 32207
• FlyBaseID: FBgn0283712
• Length: 1257
• Species: Drosophila melanogaster
• Sequence 2: NP_001036156.1
• Gene: limk1a / 735292
• ZFINID: ZDB-GENE-061212-3
• Length: 648
• Species: Danio rerio
• Alignment Length: 713
• Identity: 300/713 - (42%)
• Similarity: 408/713 - (57%)
• Gaps: 129/713 - (18%)

  Fly    15 GTGLGAGSGPVSGGHSPLCAHCRGQLLPHPEEPIVMALGQQWHCDCFRCSVCEGHLHNWYFEREG 79
            |.||            |:|:.|..|:.   ::..:.||...||..|.||..|...|.:||:|::|
Zfish    21 GVGL------------PVCSGCGQQIY---DDQYLQALSSDWHTLCCRCCECGSSLSHWYYEKDG 70

  Fly    80 LLYCREDYYGRFGDACQQCMAVI-TGPVMVAGEHKFHPECFCCTACGSFIGEGESYALVERSKLY 143
            .|:|::||:.:||:.|..|...| ||.:|||||.|:|||||.|.:||:|||:|::||||||||||
Zfish    71 RLFCKKDYWAKFGELCHGCSEPISTGLIMVAGEQKYHPECFSCLSCGAFIGDGDTYALVERSKLY 135

  Fly   144 CGQCYGKRSCQPADAK----ARITTAGKPMHSIRLVEIPKDATPGLRVDGVALDDGCP------- 197
            .|.||.:....|....    :||.      |::.||.||. :|.|.|...|::|....
Zfish   136 SGHCYYRSIVTPVSLPDSPCSRIP------HTVTLVSIPA-STDGKRGFSVSIDQASSPNGYSPE 193

  Fly   198 ---TVRITDLFCNFFLWLTSMAEQCCGAPYRIDVNLTNLHIGDRILEVNGTPVSDSSVEQIDKLI 259
               |||::.::.:            |.:|   ||. .::|:||||||:||||:.:..:::||.||
Zfish   194 HKRTVRVSQVYPD------------CISP---DVK-NSIHVGDRILEINGTPIQNVPLDEIDLLI 242

  Fly   260 RSNEKMLQLTVEHDPVQVCRSCSQADIQRAMSA--STLILPLSTSASSVEVGRERLYKTPGEQGT 322
            :...::||||:||||.....|....|...:.|.  |.:..|.|...|::   |.|:.       |
Zfish   243 QETSRLLQLTIEHDPHDQGPSVDHVDGGPSPSGGPSPITRPPSQDISNL---RSRII-------T 297

  Fly   323 KARKLRQATNASTTIPPAAGATAMTQLKEKERCSSLSKLLDEQHQAQQHSAHPQLYDLSRTQSCR 387
            ::..:.::.::|:...|.                ||.|                  |:.|::|.|
Zfish   298 RSYSIDKSPSSSSAPSPL----------------SLRK------------------DIGRSESLR 328

  Fly   388 -VVQKPQRIFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLR 451
             |..:..|||||:||:.||.||.|.||:..|||||::|||||:|||.|.|||.||.|:|||.|:|
Zfish   329 GVSNRTHRIFRASDLIHGEVLGTGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMR 393

  Fly   452 LLDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELIHDPAQVLPWPQRVRLARDIACGMSYLHSM 516
            .|||.:||||||||||||:|:.:.||:.||.|:::|.:.....||.|||..|:|||.||:|||||
Zfish   394 CLDHPNVLKFIGVLYKDKRLNFIAEYIKGGTLRDIIKNMDSNYPWGQRVSFAKDIASGMAYLHSM 458

  Fly   517 NIIHRDLNSMNCLVREDRSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRS 581
            |||||||||.||||||::||:||||||:|.:...|                         ::.|.
Zfish   459 NIIHRDLNSHNCLVRENKSVVVADFGLSRLMVEDR-------------------------SVERR 498

  Fly   582 KSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQ 646
            |: .||:|||||||||||||||:.|..||||||:||||||||||||||.||||::||..||.||.
Zfish   499 KA-DRRKRYTVVGNPYWMAPEMIHGKSYDEKVDLFSFGIMLCEIIGRVNADPDYLPRALDFGLNT 562

  Fly   647 QEFREKFC-AQCPEPFVKVAFVCCDLNPDMRPCFETLHVWLQ--RLADDLAADRVPPERLLHE 706
            ..|.|:.| |.||..|..:|.:||||:.:.||.|..|..||:  ::..:|....|....|||:
Zfish   563 AVFLEEHCPADCPAAFFPIAALCCDLDAEKRPAFTKLESWLEDLKMHLELGLHLVSELELLHQ 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750	19/54 (35%)
		LIM2_LIMK	95..148	CDD:188751	34/53 (64%)
		PDZ_LIMK-like	169..274	CDD:467236	38/114 (33%)
		STKc_LIMK	407..693	CDD:271056	161/288 (56%)
limk1a	NP_001036156.1	LIM1_LIMK1	5..79	CDD:188846	23/72 (32%)
		LIM	86..140	CDD:413332	34/53 (64%)
		PDZ_LIMK-like	159..257	CDD:467236	38/120 (32%)
		STKc_LIMK1	349..610	CDD:271123	161/286 (56%)