DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LIMK1 and Limk1

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_113915.2	Gene:	Limk1 / 65172	RGDID:	62055	Length:	647	Species:	Rattus norvegicus

Alignment Length:	715	Identity:	315/715 - (44%)
Similarity:	409/715 - (57%)	Gaps:	114/715 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GGHSPLCAHCR-----GQLLPHPEEPIVMALGQQWHCDCFRCSVCEGHLHNWYFEREGLLYCRED 86
            |...|:||.|.     ||.|        .||...||.|||||..|...|.:.|:|::|.|:|::|
  Rat    19 GSELPVCASCSQSIYDGQYL--------QALNADWHADCFRCCECSTSLSHQYYEKDGQLFCKKD 75

  Fly    87 YYGRFGDACQQCMAVIT-GPVMVAGEHKFHPECFCCTACGSFIGEGESYALVERSKLYCGQCYGK 150
            |:.|:|::|..|...|| |.||||||.|:|||||.|.|||:|||:|::|.|||.|||||||||.:
  Rat    76 YWARYGESCHGCSEHITKGLVMVAGELKYHPECFICLACGNFIGDGDTYTLVEHSKLYCGQCYYQ 140

  Fly   151 RSCQPADAKARITTAGKPM-HSIRLVEIPKDATPGLRVDGVALD-----DGC-----PTVRITDL 204
            ....|...:....:.|..: |::.||.||..| .|.|...|::|     .||     .|||:..:
  Rat   141 TVVTPVIEQILPDSPGSHLPHTVTLVSIPASA-HGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGV 204

  Fly   205 FCNFFLWLTSMAEQCCGAPYRIDVNLTNLHIGDRILEVNGTPVSDSSVEQIDKLIRSNEKMLQLT 269
                        :..|.:|   ||. .::||||||||:||||:.:..:::||.||:...::||||
  Rat   205 ------------DPGCMSP---DVK-NSIHIGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLT 253

  Fly   270 VEHDPVQVCRSCSQADIQRAMSASTLILPLSTSASSVEVGRERLYKTPGEQGTKARKLRQATNAS 334
            :||||..   |.....:.   ..|.|..|:.|.:              |:.|:.||:.....:.|
  Rat   254 LEHDPHD---SLGHGPVS---DPSPLASPVHTPS--------------GQAGSSARQKPVLRSCS 298

  Fly   335 TTIPPAAGATAMTQLKEKERCSSLSKLLDEQHQAQQHSAHPQLYDLSRTQSCRVVQKPQRIFRAT 399
            ....|.||:..                          |...|..||.|::|.|||.:|.||||.:
  Rat   299 IDTSPGAGSLV--------------------------SPASQRKDLGRSESLRVVCRPHRIFRPS 337

  Fly   400 DLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGV 464
            ||:.||.||:|.||:..|||||::|||||:|||.|.|||.||.|:|||.|:|.|:|.:|||||||
  Rat   338 DLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGV 402

  Fly   465 LYKDKKLHMVTEYVAGGCLKELIHDPAQVLPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCL 529
            |||||:|:.:|||:.||.|:.:|.......||.|||..|:|||.||:||||||||||||||.|||
  Rat   403 LYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCL 467

  Fly   530 VREDRSVIVADFGLAR-SVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVV 593
            |||:|:|:|||||||| .:|.              .|.:.|        ||..|...|::|||||
  Rat   468 VRENRNVVVADFGLARLMIDE--------------KGQSED--------LRSLKKPDRKKRYTVV 510

  Fly   594 GNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQQEFREKFC-AQC 657
            ||||||||||:.|..||||||||||||:||||||||.||||::||..||.||.:.|.:::| ..|
  Rat   511 GNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNC 575

  Fly   658 PEPFVKVAFVCCDLNPDMRPCFETLHVWLQRLADDLAADRVPPERLLHEIET-FQEWYASSEDAL 721
            |..|..:...||||:|:.||.|..|..||:.|...||. .:|....|.::|. |.|.|...|.:|
  Rat   576 PPSFFPITVRCCDLDPEKRPSFVKLEQWLETLRMHLAG-HLPLGPQLEQLERGFWETYRRGESSL 639

Fly 722 721
Rat 640 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750	23/59 (39%)
		LIM2_LIMK	95..148	CDD:188751	36/53 (68%)
		PDZ_signaling	172..271	CDD:238492	38/108 (35%)
		STKc_LIMK	407..693	CDD:271056	163/287 (57%)
Limk1	NP_113915.2	LIM1_LIMK1	5..77	CDD:188846	25/65 (38%)
		LIM2_LIMK1	84..138	CDD:188848	36/53 (68%)
		PDZ	165..255	CDD:278991	38/106 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..316		18/105 (17%)
		TyrKc	342..604	CDD:197581	162/283 (57%)
		STKc_LIMK1	345..611	CDD:271123	163/287 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	318	1.000	Domainoid score	I1222
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1738
Inparanoid	1	1.050	532	1.000	Inparanoid score	I1173
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119463at33208
OrthoFinder	1	1.000	-	-		FOG0003618
OrthoInspector	1	1.000	-	-		otm45613
orthoMCL	1	0.900	-	-		OOG6_103981
Panther	1	1.100	-	-	O	PTHR46485
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2495
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.970