Protein Alignment LIMK1 and Araf

DIOPT Version :9

• Sequence 1: NP_511139.2
• Gene: LIMK1 / 32207
• FlyBaseID: FBgn0283712
• Length: 1257
• Species: Drosophila melanogaster
• Sequence 2: XP_038955949.1
• Gene: Araf / 64363
• RGDID: 2148
• Length: 641
• Species: Rattus norvegicus
• Alignment Length: 588
• Identity: 135/588 - (22%)
• Similarity: 218/588 - (37%)
• Gaps: 163/588 - (27%)

  Fly   205 FCNFFLWLTSMAEQC--CGAPYR-----------IDVNLTNLHIGDRILEVNGTPVSDSSVEQID 256
            ||:|.|.......:|  ||..:.           :|::.........|.:::|    .|..:::.
  Rat   148 FCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSIQDLSG----GSRQQEVP 208

  Fly   257 KLIRSNEKML---------QLTVEH--------DPVQVCRSCSQADIQRAMSA----STLILPLS 300
            ..:..||.:.         |...||        .|:|..||.|..::....:.    |:|:...:
  Rat   209 SNLSVNELLTPQGPSPFTQQRDQEHFSFPAPANPPLQRIRSTSTPNVHMVSTTAPMDSSLMQFTA 273

  Fly   301 TSASSVEVGRERLYKTPGEQGTKARKLRQATNASTTIPPAAGATAMTQLKEKERCSSLSKLLDEQ 365
            .|.|:...||       |..|........|:.:|....|.:...|    :::||.|    |.||:
  Rat   274 QSFSTDAAGR-------GGDGAPRGSPSPASVSSGRKSPHSKLPA----EQRERKS----LADEK 323

  Fly   366 HQAQQHSAHPQLYDLSRTQSCRVVQKPQRIFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLK 430
            .:.:         :|....|....:.|     .:::.:.:::|.|.||.||:........|.|||
  Rat   324 KKVK---------NLGYRDSGYYWEVP-----PSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLK 374

  Fly   431 ELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELIHDPAQVLP 495
            ......|:||. |..|:.|||...|.::|.|:|.:.: ....::|::..|..|...:|.......
  Rat   375 VAQPTAEQAQA-FKNEMQVLRKTRHVNILLFMGFMTR-PGFAIITQWCEGSSLYHHLHVADTRFD 437

  Fly   496 WPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGLARSVDAPRLPSGNMTPG 560
            ..|.:.:||..|.||.|||:.|||||||.|.|..:.|..:|.:.|||||             |..
  Rat   438 MVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLA-------------TVK 489

  Fly   561 GYGSGANSDAPM-SPSGTLRRSKSRQRRQRYTVVGNPYWMAPE---MMKGLKYDEKVDVFSFGIM 621
            ...|||.   |: .|||::                  .|||.|   |.....|..:.||:::|::
  Rat   490 TRWSGAQ---PLEQPSGSV------------------LWMAAEVIRMQDPNPYSFQSDVYAYGVV 533

  Fly   622 LCEI-------------------IGRVEADPDFMPRNSDFSLNQQEFREKFCAQCPEPFVKVAFV 667
            |.|:                   :||....||.               .|..:.||:...::...
  Rat   534 LYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDL---------------SKIFSNCPKAMRRLLTD 583

  Fly   668 CCDLNPDMRPCFETLHVWLQRLADDLAADRVPPERLLHEIETFQEWYASSEDALSPTSQRSLNNL 732
            |.....:.||.|..:...::.|           :|.|.:||.     ::||.:|..|      ..
  Rat   584 CLKFQREERPLFPQILATIELL-----------QRSLPKIER-----SASEPSLHRT------QA 626

  Fly   733 DEL 735
            |||
  Rat   627 DEL 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751
		PDZ_signaling	172..271	CDD:238492	14/87 (16%)
		STKc_LIMK	407..693	CDD:271056	82/308 (27%)
Araf	XP_038955949.1	RBD_ARAF	56..128	CDD:340653
		C1_A_C-Raf	133..184	CDD:410420	7/35 (20%)
		PKc_like	344..608	CDD:419665	82/325 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000