DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LIMK1 and RAF1

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_001341618.1	Gene:	RAF1 / 5894	HGNCID:	9829	Length:	668	Species:	Homo sapiens

Alignment Length:	698	Identity:	156/698 - (22%)
Similarity:	247/698 - (35%)	Gaps:	208/698 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 YGKRSCQPADAKARITTAGKPMHSIRLVEIPKDATPGLRV-DGVALDDGCPTVRITDLFCNF-FL 210
            |.:|    |....::|...|..::|| |.:|......:.| :|::|.|           |.. .|
Human    38 YQRR----ASDDGKLTDPSKTSNTIR-VFLPNKQRTVVNVRNGMSLHD-----------CLMKAL 86

  Fly   211 WLTSMAEQCCGAPYRIDVNLTNLHIGDRI-LEVNGTPVS----DSSVEQIDKLIRSNEKMLQLTV 270
            .:..:..:|| |.:|    |.:.|.|.:. |:.|....|    :..|:.:|.:..:.....:.|.
Human    87 KVRGLQPECC-AVFR----LLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTF 146

  Fly   271 ---------------------------EHDPVQVCRSCSQADIQRAMSASTLILPLST------- 301
                                       ||...:|...|    :..:.....|:.|.||
Human   147 LKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMC----VDWSNIRQLLLFPNSTIGDSGVP 207

  Fly   302 ------------SASSVEVGRERLYKT----------PGEQGTKARKLRQATN-----ASTTIPP 339
                        |.|.:.|..:..|.|          |..:|:.:::.|..:.     .|||:|.
Human   208 ALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPV 272

  Fly   340 AAGATAMTQLKEKERCSSLSKLLDEQHQAQQHS----------------------------AHPQ 376
            .:.......|....|..|....|..:...:.||                            |..:
Human   273 DSRMIENNNLSASPRAWSRRFCLRGRDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRE 337

  Fly   377 LYDLSRTQSCRVVQ-KPQR------IFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHR 434
            ...:|.||....:: :.||      ...|:::::..::|.|.||.|:|........|.:||.:..
Human   338 RAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDP 402

  Fly   435 ADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELIHDPAQVLPWPQR 499
            ..|:.|. |..||||||...|.::|.|:|.:.|| .|.:||::..|..|.:.:|.........|.
Human   403 TPEQFQA-FRNEVAVLRKTRHVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQL 465

  Fly   500 VRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGLARSVDAPRLPSGNMTPGGYGS 564
            :.:||..|.||.|||:.||||||:.|.|..:.|..:|.:.||||| :|.:
Human   466 IDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLA-TVKS--------------- 514

  Fly   565 GANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPE---MMKGLKYDEKVDVFSFGIMLCEI- 625
                          |.|.|:|..|   ..|:..|||||   |.....:..:.||:|:||:|.|:
Human   515 --------------RWSGSQQVEQ---PTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELM 562

  Fly   626 ------------------IGRVEADPDFMPRNSDFSLNQQEFREKFCAQCPEPFVKVAFVCCDLN 672
                              :||..|.||.               .|....||:...::...|....
Human   563 TGELPYSHINNRDQIIFMVGRGYASPDL---------------SKLYKNCPKAMKRLVADCVKKV 612

  Fly   673 PDMRPCFETLHVWLQRLADDL-AADRVPPERLLHEIETFQEWYASSED 719
            .:.||.|..:...::.|...| ..:|...|..||..       |.:||
Human   613 KEERPLFPQILSSIELLQHSLPKINRSASEPSLHRA-------AHTED 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751	156/698 (22%)
		PDZ_signaling	172..271	CDD:238492	23/132 (17%)
		STKc_LIMK	407..693	CDD:271056	87/307 (28%)
RAF1	NP_001341618.1	Raf_RBD	57..131	CDD:176411	21/90 (23%)
		C1_1	139..187	CDD:278556	5/51 (10%)
		STKc_C-Raf	356..638	CDD:271051	90/331 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910