Protein Alignment LIMK1 and tesk2

DIOPT Version :10

• Sequence 1: NP_511139.2
• Gene: LIMK1 / 32207
• FlyBaseID: FBgn0283712
• Length: 1257
• Species: Drosophila melanogaster
• Sequence 2: NP_001103946.1
• Gene: tesk2 / 568213
• ZFINID: ZDB-GENE-070209-68
• Length: 634
• Species: Danio rerio
• Alignment Length: 760
• Identity: 202/760 - (26%)
• Similarity: 309/760 - (40%)
• Gaps: 241/760 - (31%)

  Fly   400 DLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGV 464
            |..|.|.:|.|||.:|:||.||.|.:||.||....:...|  |.::||.::..|.|.::|:|:||
Zfish    57 DDFICEWIGSGFFSEVYKVRHRASDQVMALKMNKLSSNRA--NMLREVQLMNRLSHPNILRFMGV 119

  Fly   465 LYKDKKLHMVTEYVAGGCLKELIHDPAQVLPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCL 529
            ..::.:||.:|||:.||.|::|: |..:.|.|..||:||.:||.|:|||||..|.||||.|.|||
Zfish   120 CVQEGQLHALTEYINGGNLEQLL-DSNKFLSWATRVKLALEIAMGLSYLHSKGIFHRDLTSKNCL 183

  Fly   530 VREDR---SVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYT 591
            ::.|.   :.||.|||||.     ::||.:                            ...::.:
Zfish   184 IKSDENGYTAIVGDFGLAE-----KIPSHD----------------------------YEGEKLS 215

  Fly   592 VVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQQEFREKFCAQ 656
            |||:|:|||||:::...|:||.||||:||:|||||.|::||||::||..:|.|:...| :.....
Zfish   216 VVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYHAF-QHMVGD 279

  Fly   657 CPEPFVKVAFVCCDLNPDMRPCFETLHVWLQRLADDLAADRVPPERLLHEIETFQEWYASSEDAL 721
            ||..|:::||.||:::|.:||.|..:...|:.:...|.|:....||:|
Zfish   280 CPADFLQLAFNCCNMDPKLRPSFPDIVKRLEEIQKKLKAEESERERML----------------- 327

  Fly   722 SPTSQRSLNNLDELVKSAVDSEISPVEK---EKENMVIKP---QD---IPKSPHLGKDFSPSGER 777
                           .:|.:.|..|:.|   ||....:.|   ||   .||||...::...|  |
Zfish   328 ---------------LTAGEVEKKPIPKGPGEKGIKRLNPLGFQDDKIPPKSPRPRRNIWLS--R 375

  Fly   778 LRDSMRARRRQRFLGAQEERRNLTPDTESKERALKKALKKCRPFGERGYLVDLRAGAELQLEDVR 842
            .:..:.||:..|.:..|:...|..|      |.....|.|..||..|   .||: |.:::..|:.
Zfish   376 SQSDIFARKPARKVNVQDPYYNPEP------RGFIHGLPKVNPFSAR---EDLK-GGKIKFYDMP 430

  Fly   843 ---------DLNTYSDVDSSCDTSLNYHDVNNLPAAQEDENTVKPGKEELLEESTNKPSNQESQH 898
                     ||::.....||.....|....||.|     |....||:
Zfish   431 SKSVFSLMFDLHSPHGSQSSQQPQPNISGANNWP-----EPWQLPGR------------------ 472

  Fly   899 HRLAIDDMRTRLNQCRS-----KFEHLE-----------EASRRNFNQSQHSMKNFFKTPPVALK 947
                         ||||     :..|.|           ||::.|....|.::.::.|...|
Zfish   473 -------------QCRSLPVSPQLPHSEVLFSSHPASRSEAAQPNGESRQRTLNSWAKKFTV--- 521

  Fly   948 MFQRLEHEAAALNGGNNCPPPPPRTQRINQTPIFGRKNPPVAIVGQKLQHAESLEDLASSGVAKQ 1012
                           ...||..||..|                    .:..|:.||.:|
Zfish   522 ---------------TEIPPYKPRADR--------------------EEEVEATEDWSS------ 545

  Fly  1013 LATPAPKRSKATATTKGGQSSNPPLFLPPSLNISVALNSNGNVT----TTTNT--NSSCPPSASD 1071
                       ...:.||::.        :::.|   :|.|:..    ||.|.  |..|....::
Zfish   546 -----------LIPSDGGETE--------AMDCS---SSRGSPADDKDTTLNQMHNGFCEDMEAE 588

  Fly  1072 -----WLPKKHKLTLPLPSAQQQ----------RTSSNHRLPMCN 1101
                 .:..|:.|||.:....|:          .:||..|:..|:
Zfish   589 DQDGVLVTNKNSLTLSMSVEPQELCPIVLTACKASSSGERISRCD 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751
		PDZ_LIMK-like	169..274	CDD:467236
		STKc_LIMK	407..693	CDD:271056	112/288 (39%)
tesk2	NP_001103946.1	PKc_TESK	64..316	CDD:271057	112/288 (39%)