DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LIMK1 and map3k21

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	XP_005156983.1	Gene:	map3k21 / 561518	ZFINID:	ZDB-GENE-090312-24	Length:	1017	Species:	Danio rerio

Alignment Length:	984	Identity:	213/984 - (21%)
Similarity:	331/984 - (33%)	Gaps:	316/984 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   399 TDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEE--AQRNFIKEVAVL-RLLDHRHVLK 460
            ::||:.|.:|.|.||||::.|.:.. ||.|.......||:  |..:.:|:.|.| .:|.|.:::|
Zfish   123 SELVLQEIIGVGGFGKVYRGTWKVQ-EVAVKAARQDPDEDIKATADSVKQEAKLFSMLQHPNIIK 186

  Fly   461 FIGVLYKDKKLHMVTEYVAGGCLKELI---HDPAQVLPWPQRVRLARDIACGMSYLHS---MNII 519
            ..||..::..|.:|.||..||.|...:   ..|..:|     |..|..||.||.|||.   :.||
Zfish   187 LEGVCLEEPNLCLVMEYARGGTLNRALTGRRIPPHIL-----VNWAVQIARGMQYLHEEAVVPII 246

  Fly   520 HRDLNSMNCLVRED--------RSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSG 576
            ||||.|.|.|:.|.        :::.:.||||||.                   .:....||.:|
Zfish   247 HRDLKSSNILLLEKIENDDIGRKTLKITDFGLARE-------------------WHKTTKMSAAG 292

  Fly   577 TLRRSKSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEII-GRVEADPDFMPRNS 640
            |            |:      |||||::|...:.:..||:|:|::|.|:: |.:..      |..
Zfish   293 T------------YS------WMAPEVIKSSLFSKGSDVWSYGVLLWELLTGEIPY------RGI 333

  Fly   641 D-----FSLNQQEFREKFCAQCPEPFVKVAFVCCDLNPDMRPCFETLHVWLQRLADDLAAD---- 696
            |     :.:...:......:.|||||.|:...|.:.:|.:||.|..:...|..:.:.:.|.
Zfish   334 DGLAVAYGVAVNKLTLPIPSTCPEPFAKLMEECWEQDPHIRPSFAAILEQLTAIEEAVMATMPQD 398

  Fly   697 ---------RVPPERLLHEIETFQEWYASSEDALSPTSQRSLNNLDELVK----SAVDSEISPVE 748
                     ||..:.:..|:.|.::...|.|:.|:..:.:..:: :||:|    ...:.||:.:|
Zfish   399 SFHSMQEDWRVEIQEMFDELRTKEKELRSREEELTRAALQQKSH-EELLKRREQQLAEREINVLE 462

  Fly   749 KEKE------------------------------NMVIKPQD------IPKSPHLGKDFS----- 772
            :|..                              |.:..|.|      :..||.:.|..|
Zfish   463 RELNILIFQQNKDKPNVKKRKGKFKRSRLKLKDGNRISLPSDFQHKITVQASPTMDKRRSLNSTN 527

  Fly   773 ---PSGERLRDSMRA----------RRRQRFLGAQ---------------------EERRNLTPD 803
               ||...|...:||          |:...|:..|                     |..|.....
Zfish   528 SSPPSSPTLIPRLRAIQLSHRGDTSRKGSMFVYHQDVDVTSECKPPSVFSKKVTLDESNRTWGRS 592

  Fly   804 TESK----ERALKKALKKCRPFG-------ERGYLVDLRAGAELQLEDVRDLNTYSDVDSSCDTS 857
            |..|    |...|...||.|.:|       |||      .||    |.:|.|   ||..|...||
Zfish   593 TNYKPEEFEDVKKGFKKKGRTWGPSSVQTKERG------NGA----ERIRPL---SDGSSPWSTS 644

  Fly   858 LNYHDVNNLPAAQ--EDENTVKPGKEEL--LEESTNKP---------------------SNQ--- 894
            | .....::|.|.  .|:.|   .|:|.  .:.|.|||                     .||
Zfish   645 L-LKSQKSVPLAALFADQGT---NKDEAGSADSSDNKPKQLKFPNQVYIDLPLWKDEPGENQSST 705

  Fly   895 ----ESQHHRLAIDDMRTRLNQCRSKFEHLEEASRRNFNQSQHSMKNFFKTPPVALKMFQRLEHE 955
                |||      :|..|..:...:..:|....|.:.....:.:....:....:...:....:.:
Zfish   706 GGGAESQ------EDPTTSTSSTSTTPQHTPTNSLKRSTTRRRTDSVLYGCASILASVAFGFDLQ 764

  Fly   956 AAALNGGNNCPPPPPRTQRINQTPIFGR-------KNPPVAIVGQKLQHAESLEDLASSGVAKQL 1013
            ....|..|.  .|.||.::..:..:|.|       .:||         ...|.:|..|:.....|
Zfish   765 EICKNPANE--EPEPREEKKKKEGLFQRATRFRRSTSPP---------GGRSRKDEISTAPVNLL 818

  Fly  1014 ATPAPKRSKATATTKGGQSSNPPLFLPPSLNISVALNSNGNVTTTTNTNSSCPPSASDWLPKKHK 1078
            |..:.....:|..........|...|.....||...|..|.
Zfish   819 AMSSISECNSTKCLLQSDFEGPGFNLVNETGISPQSNGTGE------------------------ 859

  Fly  1079 LTLPLPSAQQQRTSSNHRL-------PMCNNKGKTLKPLPSRTGSQGIPASNCVSPTRS------ 1130
             .|.|...|:..:.:|.||       .:|.|.          .||...|.|...|.|.|
Zfish   860 -GLHLTPVQELSSGANSRLRRKKSSPAVCQNV----------NGSSNSPVSPADSSTTSTKKKAD 913

  Fly  1131 --------------SRPGSPTKHLAQRHTAATAQRLTNAAATHQQQHQQQSSKTTRLNILSPEKV 1181
                          |||    :.|:.|..:.:...|.:...::...|.........|::|.|.:|
Zfish   914 KEPPQDKQTSGESVSRP----RPLSLRGKSHSWSLLKSRNKSYSLGHYSGEKSVQNLDMLLPAEV 974

  Fly  1182 HRLGARLTD 1190
             :.|..|.|
Zfish   975 -KTGCSLLD 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751
		PDZ_signaling	172..271	CDD:238492
		STKc_LIMK	407..693	CDD:271056	87/308 (28%)
map3k21	XP_005156983.1	SH3_MLK1-3	42..99	CDD:212992
		TyrKc	125..384	CDD:197581	89/307 (29%)
		STKc_MLK4	130..387	CDD:271048	87/305 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910