Protein Alignment LIMK1 and map3k10

DIOPT Version :9

• Sequence 1: NP_511139.2
• Gene: LIMK1 / 32207
• FlyBaseID: FBgn0283712
• Length: 1257
• Species: Drosophila melanogaster
• Sequence 2: XP_689424.4
• Gene: map3k10 / 560932
• ZFINID: ZDB-GENE-050419-112
• Length: 1062
• Species: Danio rerio
• Alignment Length: 1141
• Identity: 246/1141 - (21%)
• Similarity: 405/1141 - (35%)
• Gaps: 331/1141 - (29%)

  Fly   278 CRSCSQADIQRAMSASTLILPLSTSASSVEVGRERLYKTPGEQGTKARKLRQATNASTTIPPAA- 341
            |......|.|...:::..::.:::|.:|..:        |...|:....|.....:|.|...|.
Zfish    30 CGHLVPPDTQANTNSTPFLISINSSRNSSTI--------PSSVGSPDSHLPHHHESSNTYWTAVF 86

  Fly   342 --GATAMTQLKEK-----ERCSSLSKLLDEQ-----------------HQAQQHSAHPQLYDLSR 382
              .|||..:|..:     |..|..||:..::                 :..|:.|::|.|
Zfish    87 DYEATADEELTLRRGDLLEVLSKDSKVSGDEGWWTGKIQDKVGIFPCNYVTQRDSSYPAL----- 146

  Fly   383 TQSCRVVQKPQRIFRA--------TDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEE- 438
                    .|:.:...        .:|.:.|.:|.|.||||:|...| :.||.|.......||:
Zfish   147 --------PPEALVGGDSPLEIDFLELRLEEVIGAGGFGKVYKGVWR-AEEVAVKAARQDPDEDI 202

  Fly   439 --AQRNFIKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELIHD---PAQVLPWPQ 498
              ...|..:|..:..:|.||:::...||..::..|.:|.||..||.|...:..   |.:||
Zfish   203 SATAENVRQEARLFWMLRHRNIIALRGVCLREPNLCLVMEYARGGALNRALAGKKVPPRVL---- 263

  Fly   499 RVRLARDIACGMSYLHSMN---IIHRDLNSMNCLV-----RED---RSVIVADFGLARSVDAPRL 552
             |..|..||.||.|||:..   ||||||.|.|.|:     |:|   :::.:.||||||.
Zfish   264 -VNWAVQIATGMDYLHNQTFVPIIHRDLKSSNILILEPVERDDLSGKTLKITDFGLARE------ 321

  Fly   553 PSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFS 617
                         .:....||.:||..                  |||||::|...:.:..||:|
Zfish   322 -------------WHRTTKMSAAGTYA------------------WMAPEVIKLSLFSKSSDVWS 355

  Fly   618 FGIMLCEII-GRVEADPDFMPRNSD-----FSLNQQEFREKFCAQCPEPFVKVAFVCCDLNPDMR 676
            ||::|.|:: |.|..      |..|     :.:...:......:.|||.|.::...|...||..|
Zfish   356 FGVLLWELLTGEVPY------REIDALAVAYGVAMNKLTLPIPSTCPEAFAQLLGECWCPNPRGR 414

  Fly   677 PCFETLHVWLQRLAD---------------DLAAD-RVPPERLLHEIETFQEWYASSEDALSPTS 725
            |.|.::   |:||.|               .|..| |:..:::..|:...::...|.|:||:..:
Zfish   415 PAFGSI---LKRLEDIEQSAMFQMPLESFHSLQEDWRLEIQQMFDELRAKEKELRSWEEALARAA 476

  Fly   726 QRSLNNLDEL---VKSAVDSEISPVEKEKENMVI------KPQ------DIPKSP--HLGKDFS- 772
            :......:.|   .:...:.||..||:|. |::|      |||      :..||.  .||:|.:
Zfish   477 EEQREQEEHLRRREQELAEREIDIVEREL-NIIIHQMYQEKPQVKKRKGNFKKSRLLKLGRDSNC 540

  Fly   773 ---PSGERLRDSMRAR------------------------RRQRFLGAQEERRNLTPD----TES 806
               |||...:.:::|.                        |.:.|        .|||.    |..
Zfish   541 ISLPSGFEHKITVQASPSVDKRKCQSSESTTPPASPGVIPRLRAF--------RLTPSDGRKTWG 597

  Fly   807 KERALKK----ALKKCRPFGERGYLVDLRAGAELQLEDVRDLNTYSDVDSSCDTS-------LNY 860
            :....||    ..||.|.:|........|.|.|.:|:.:.:...:|....:...|       ..:
Zfish   598 RTAVCKKEEPGTKKKGRTWGPSSTHQRERVGGEDRLKSLGEGKVWSSSAPNLGKSPKHAPMTAGF 662

  Fly   861 HDVNNLPAAQEDENTVKPGK-----------EELLEESTNKPSNQESQHHRLAIDDMRTRLNQ-- 912
            ..:|.:....|.::: .||:           |::...|....|...||       |...|.:|
Zfish   663 SSLNEMEEHCEFDDS-SPGRLAPDLGSNGALEDVGSGSAGLGSGIGSQ-------DSVCRCSQRK 719

  Fly   913 --------CRSKF------EHLEEASRRNFNQSQHSMKNFFKTPPVALKMFQRLEHEAAALNGG- 962
                    |.|..      ..:.:..|:..||.:..::.           .||.:.|......|
Zfish   720 KSDLLLLGCASLLAVVGLGSDILQLGRQQMNQDEQDVRE-----------EQRKKKEGLFQRTGR 773

  Fly   963 -NNCPPPPPRTQRINQT---------PIFGRKNPPVAIVGQKLQHAESLEDLASSGVAKQLATPA 1017
             .....||.||..::.:         |... .:|.|.::        ||..|:.....|.|....
Zfish   774 FRRSTSPPSRTLSLSLSHNRHHDSILPSMD-PSPSVTLL--------SLSSLSDCNSTKSLLPSD 829

  Fly  1018 PKRSKATATTKGGQSSNPPLFLP-PSLNISVALNSNGNVTTTTNTNSSCPP---SASDWLPKKHK 1078
            |.....|      .|:.||:..| |:||..:.|.:.   :.....|.|..|   ||:..|.:.|:
Zfish   830 PDDFAPT------PSNAPPVVSPAPALNPLLDLRAE---SFKREPNQSLTPTHVSATMALNRGHR 885

  Fly  1079 LTLP-----LPSAQ----QQRTSSNHRLPMCNNKGKTLKPLPSRTGSQ------GIPASNCVSPT 1128
            .| |     .|.||    .:||.|:..:|.......|:.|.   |||:      .:|..:.:.|:
Zfish   886 RT-PSDGAIRPRAQTVVGHRRTPSDGSMPFPPAHAPTITPY---TGSRETLDIPRLPDPSMMFPS 946

  Fly  1129 ---RSSRPGSPTKHLAQRHTAATAQRLTNAAATHQQQHQQQSSKTTRLNILSPEKVHRLGARLTD 1190
               |...|..||.. ...:|....:..|...|...:.              :|.:......:|:.
Zfish   947 ALRRKPAPPIPTPE-PDSYTGTLERPKTLEFAPRPRP--------------TPARARPDPWKLSS 996

  Fly  1191 QKQKMREEAAATASSVGGAGCAAGTAAGSLNGHRTI 1226
            ..|.:.....::..|..|:| .:|.:||:...|:::
Zfish   997 LSQTLSSSPGSSCDSPLGSG-DSGVSAGTGGVHQSL 1031

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751
		PDZ_signaling	172..271	CDD:238492
		STKc_LIMK	407..693	CDD:271056	91/323 (28%)
map3k10	XP_689424.4	SH3_MLK1-3	81..138	CDD:212992	9/56 (16%)
		STYKc	165..424	CDD:214568	90/310 (29%)
		STKc_MLK2	170..427	CDD:271050	90/308 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910