DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LIMK1 and limk2

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_001002651.1	Gene:	limk2 / 436924	ZFINID:	ZDB-GENE-040718-398	Length:	651	Species:	Danio rerio

Alignment Length:	717	Identity:	292/717 - (40%)
Similarity:	397/717 - (55%)	Gaps:	97/717 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 CAHCRGQLLP--HPEEPIVMALGQQWHCDCFRCSVCEGHLHNWYFEREGLLYCREDYYGRFGDAC 95
            |..|.|::..  |     |..|...||..||:||||...|.|||||:||.|:|.:.|..:||:.|
Zfish    12 CTGCGGRIQDAFH-----VKVLQDAWHNSCFQCSVCFDLLTNWYFEKEGRLFCHKHYCEKFGELC 71

  Fly    96 QQCMAVITGPVMVAGEHKFHPECFCCTACGSFIGEGESYALVERSKLYCGQCYGKRSCQPADAKA 160
            ..|..::|||.||||::|:|||||.|.:|...|.:.::||||||:|||||:||.:....|...|.
Zfish    72 HGCSLLMTGPAMVAGDYKYHPECFVCLSCRVVIEDRDTYALVERTKLYCGKCYKQVVLTPVLEKR 136

  Fly   161 RITTAGKPM--HSIRLVEIPKDATPGLRVDGVALDDGC----PTVRITDLFCNFFLWLTSMAEQC 219
            .:..:...:  |::.||.:|. ||.|.|...|::...|    .:|::.::
Zfish   137 GLADSPSDLLPHTVTLVSMPA-ATNGKRGFSVSVIRDCTSAIASVQVKEV--------------- 185

  Fly   220 CGAPYRIDVNLTN-LHIGDRILEVNGTPVSDSSVEQIDKLIRSNEKMLQLTVEHDPVQVCRSCSQ 283
              ....|...:.| :|:||||||:||.||:....|:::.||....:.|||.:|:|||:     .:
Zfish   186 --RGMHISPEVRNAIHVGDRILEINGLPVTSLIEEEVEDLIHRTSQTLQLLMEYDPVR-----QR 243

  Fly   284 ADIQRAMS-ASTLILPLSTS---ASSVEVGRERLYKTPGEQGT-KARKLRQATNASTTIPPAAGA 343
            .|..|..| .:.|.:|:.:.   :|.|:...||  ....:.|| |.|.||::.:.
Zfish   244 LDRLRLGSPRNKLGVPVVSRMRLSSPVDAEIER--SDTVDNGTLKRRSLRRSNSI---------- 296

  Fly   344 TAMTQLKEKERCSSLSKLLDEQHQAQQHSAHPQLYDLSRTQSCRVVQK-PQRIFRATDLVIGEKL 407
                       |.|......:.|.....       |:.|::|.|.... ..||||..||:.||.|
Zfish   297 -----------CKSPVSSSPKDHLVLTR-------DIGRSESLRSPSSCSHRIFRPCDLIHGEIL 343

  Fly   408 GEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDKKLH 472
            |:||||:..||||:.:|||||:|||.|.|||.|:.|:|||.|:|.|||.|||||||||||||:|:
Zfish   344 GKGFFGQAIKVTHKATGEVMVMKELIRCDEETQKTFLKEVKVMRSLDHTHVLKFIGVLYKDKRLN 408

  Fly   473 MVTEYVAGGCLKELIHDPAQVLPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRSVI 537
            ::||::.||.||:.|.| ....||.|||..|:.||.||:|||||:||||||||.||||:.|.:|:
Zfish   409 LITEFIEGGTLKDFIRD-TDSFPWEQRVSFAKSIASGMAYLHSMSIIHRDLNSHNCLVKLDNTVV 472

  Fly   538 VADFGLARSV--DAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMA 600
            ||||||:|.:  |..:.|                .|..|:...|..:...|::||||||||||||
Zfish   473 VADFGLSRLIMEDKVKQP----------------PPDKPTNKKRLFRRIDRKKRYTVVGNPYWMA 521

  Fly   601 PEMMKGLKYDEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQQEFREKFCAQ-CPEPFVKV 664
            |||:.|.:||||||:|||||:||||||:|.|||:.:||..||.||.:.|.|||..: ||..|..:
Zfish   522 PEMLNGKRYDEKVDIFSFGIVLCEIIGQVYADPECLPRTLDFGLNVRTFIEKFLPEHCPPAFFAL 586

  Fly   665 AFVCCDLNPDMRPCFETLHVWLQRLADDLAADRVPPERLLHEIETFQEWYASSEDALSPTSQRSL 729
            |..||||.||.||.|:.|....:.|..:...:...|..|....:.|...|..||.|    |:...
Zfish   587 AVACCDLTPDNRPAFQKLEDCFEALTFNQELNIPLPAELDELQQKFLRTYGPSEIA----SENQE 647

  Fly   730 NN 731
            ||
Zfish   648 NN 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750	24/56 (43%)
		LIM2_LIMK	95..148	CDD:188751	29/52 (56%)
		PDZ_signaling	172..271	CDD:238492	29/103 (28%)
		STKc_LIMK	407..693	CDD:271056	158/288 (55%)
limk2	NP_001002651.1	LIM1_LIMK2	12..64	CDD:188847	24/56 (43%)
		LIM2_LIMK2	66..124	CDD:188849	31/57 (54%)
		PDZ	152..234	CDD:278991	28/99 (28%)
		STYKc	340..608	CDD:214568	159/284 (56%)
		STKc_LIMK2	343..615	CDD:271124	158/288 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	316	1.000	Domainoid score	I1247
eggNOG	1	0.900	-	-		E33208_3BEDK
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1254
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119463at33208
OrthoFinder	1	1.000	-	-		FOG0003618
OrthoInspector	1	1.000	-	-		otm24750
orthoMCL	1	0.900	-	-		OOG6_103981
Panther	1	1.100	-	-	LDO	PTHR46485
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2495
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.830