Protein Alignment LIMK1 and MAP3K11

DIOPT Version :10

• Sequence 1: NP_511139.2
• Gene: LIMK1 / 32207
• FlyBaseID: FBgn0283712
• Length: 1257
• Species: Drosophila melanogaster
• Sequence 2: NP_002410.1
• Gene: MAP3K11 / 4296
• HGNCID: 6850
• Length: 847
• Species: Homo sapiens
• Alignment Length: 823
• Identity: 189/823 - (22%)
• Similarity: 302/823 - (36%)
• Gaps: 233/823 - (28%)

  Fly   392 PQRIFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEE----AQRNFIKEVAVLRL 452
            |..:....:|.:.|.:|.|.||||::.:.|  ||::.:|...:..:|    ...:..:|..:..:
Human   108 PCEVASFQELRLEEVIGIGGFGKVYRGSWR--GELVAVKAARQDPDEDISVTAESVRQEARLFAM 170

  Fly   453 LDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELI---HDPAQVLPWPQRVRLARDIACGMSYLH 514
            |.|.:::....|..::..|.:|.||.|||.|...:   ..|..||     |..|..||.||.|||
Human   171 LAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVL-----VNWAVQIARGMHYLH 230

  Fly   515 S---MNIIHRDLNSMNCLV--------REDRSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANS 568
            .   :.:|||||.|.|.|:        .|.:::.:.||||||.                   .:.
Human   231 CEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLARE-------------------WHK 276

  Fly   569 DAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEII-GRVEAD 632
            ...||.:||..                  |||||::|...:.:..||:|||::|.|:: |.|..
Human   277 TTQMSAAGTYA------------------WMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPY- 322

  Fly   633 PDFMPRNSD-----FSLNQQEFREKFCAQCPEPFVKVAFVCCDLNPDMRPCFETLHVWLQRLADD 692
                 |..|     :.:...:......:.|||||.::...|...:|..||.|.::   ||:|
Human   323 -----RGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASI---LQQL--- 376

  Fly   693 LAADRVPPERLLHEIETFQEWYASSEDALSPTSQRSLNNL-DELVKSAVDSEISPVEKEKENMVI 756
                    |.|  |.:..:|....|..::....:|.:..| |||           ..|||| ::.
Human   377 --------EAL--EAQVLREMPRDSFHSMQEGWKREIQGLFDEL-----------RAKEKE-LLS 419

  Fly   757 KPQDIPKSPHLGKDFSPSGERLRDSMRARRRQRFLGAQEE----RRNLT----------PDTESK 807
            :.:::.::         :.|:...:.:.|||:..| ||.|    .|.||          |....:
Human   420 REEELTRA---------AREQRSQAEQLRRREHLL-AQWELEVFERELTLLLQQVDRERPHVRRR 474

  Fly   808 ERALKKALKKCRPFGER-------GYLVDLRAGAELQLEDVRDLNTYSDVDSSCDTSLNYHDVNN 865
            ....|::..:.|..|||       .:.:.::|...|.    |..|.:........|...:..:..
Human   475 RGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLD----RRRNVFEVGPGDSPTFPRFRAIQL 535

  Fly   866 LPAAQEDENTVKPGK------EELLEESTN--------------KPSNQESQHHRLAIDDMRTRL 910
            .||        :||:      ...||:|:|              ||...::...|..:|:....|
Human   536 EPA--------EPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYL 592

  Fly   911 NQCRSKFEHLEEASRRNFNQSQHSMKNFFKTPPVALKMFQRLEHEAAALNGGNNCPPPPPRTQRI 975
                              :....|......|||              ||||.   ||.|......
Human   593 ------------------DSDDSSPLGSPSTPP--------------ALNGN---PPRPSLEPEE 622

  Fly   976 NQTPI---FGRKNPPVAIVGQKLQHAESLEDLASSGVAKQLATP-APKRSKA-TATTKGGQSSNP 1035
            .:.|:   .|..:....::.:.|....:|  |||.|:.:.|..| .|.|.:. :.||....:..|
Human   623 PKRPVPAERGSSSGTPKLIQRALLRGTAL--LASLGLGRDLQPPGGPGRERGESPTTPPTPTPAP 685

  Fly  1036 -PLFLPPSLNISVALNSNGNVTTTTNTNSSCPPSASDWLPKKHKLTLPLPSAQQQRTSSNHRLPM 1099
             |...|||..|..:|.:           ...||:.:..|     |.|.:|..|:...|.....
Human   686 CPTEPPPSPLICFSLKT-----------PDSPPTPAPLL-----LDLGIPVGQRSAKSPRREE-- 732

  Fly  1100 CNNKGKTLKPLP----SRTGSQGIPASNCVSPTRSSRPGSPTK 1138
             ..:|.|:.|.|    |..|:.|.|.|..:......|| ||.:
Human   733 -EPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRP-SPLR 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751
		PDZ_LIMK-like	169..274	CDD:467236
		STKc_LIMK	407..693	CDD:271056	84/309 (27%)
MAP3K11	NP_002410.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	11..38
		SH3_MLK1-3	45..102	CDD:212992
		STKc_MLK3	113..379	CDD:271049	87/329 (26%)
		Leucine-zipper 1	403..424		8/32 (25%)
		Leucine-zipper 2	438..459		9/21 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	537..643		26/148 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	655..847		35/139 (25%)