Protein Alignment LIMK1 and MAP3K9

DIOPT Version :9

• Sequence 1: NP_511139.2
• Gene: LIMK1 / 32207
• FlyBaseID: FBgn0283712
• Length: 1257
• Species: Drosophila melanogaster
• Sequence 2: XP_011535090.1
• Gene: MAP3K9 / 4293
• HGNCID: 6861
• Length: 1166
• Species: Homo sapiens
• Alignment Length: 1183
• Identity: 240/1183 - (20%)
• Similarity: 390/1183 - (32%)
• Gaps: 359/1183 - (30%)

  Fly   290 MSASTLILPLSTSASSVEVGRERLYKTPGEQGTKA---RKLRQATNASTTIPP------------ 339
            |..|..:|....||::.        ..|||.|..|   .:..:...|:..:.|
Human     1 MEPSRALLGCLASAAAA--------APPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYW 57

  Fly   340 -------AAGATAMTQLKEKERCSSLSKLLDEQHQA------------QQHSAHPQLYDLSRT-- 383
                   |||...:|.     |...:.::|.:..|.            |:....|..|...|:
Human    58 TAVFEYEAAGEDELTL-----RLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAF 117

  Fly   384 ----------QSCRVVQKPQRIFRA--TDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRAD 436
                      .||   ..|.::...  .:|.:.|.:|.|.||||:: ......||.|....|..|
Human   118 SSRCQPGGEDPSC---YPPIQLLEIDFAELTLEEIIGIGGFGKVYR-AFWIGDEVAVKAARHDPD 178

  Fly   437 EEAQR---NFIKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELIHD---PAQVLP 495
            |:..:   |..:|..:..:|.|.:::...||..|:..|.:|.|:..||.|..::..   |..:|
Human   179 EDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDIL- 242

  Fly   496 WPQRVRLARDIACGMSYLHS---MNIIHRDLNSMNCLVRE--------DRSVIVADFGLARSVDA 549
                |..|..||.||:|||.   :.||||||.|.|.|:.:        ::.:.:.||||||.
Human   243 ----VNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE--- 300

  Fly   550 PRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVD 614
                            .:....||.:||..                  |||||:::...:.:..|
Human   301 ----------------WHRTTKMSAAGTYA------------------WMAPEVIRASMFSKGSD 331

  Fly   615 VFSFGIMLCEII-GRVEADPDFMPRNSD-----FSLNQQEFREKFCAQCPEPFVKVAFVCCDLNP 673
            |:|:|::|.|:: |.|..      |..|     :.:...:......:.|||||.|:...|.:.:|
Human   332 VWSYGVLLWELLTGEVPF------RGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDP 390

  Fly   674 DMRPCF--------------------ETLHV----W---LQRLADDLAADRVPPERLLHEIETFQ 711
            ..||.|                    ::.|.    |   :|.:.|.|.|..       .|:.|::
Human   391 HSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKE-------KELRTWE 448

  Fly   712 EWYASSEDALSPTSQRSLNNLDELVKSAVDSEISPVEKEKENMVIKP--QDIPKSPHLGKDFSPS 774
            |  ..:..||...:|..|  |....:...:.||..:|:|. |::|..  |:.|:.......|..|
Human   449 E--ELTRAALQQKNQEEL--LRRREQELAEREIDILEREL-NIIIHQLCQEKPRVKKRKGKFRKS 508

  Fly   775 GERLRDSMRARRRQRFLGAQEERRNLTPDTESKERALKKALKKCRPFGERGYLVDLRAGAELQLE 839
            ..:|:|..|......|   |.:.......|..|.::|..:  :..|......:..|||   :|.|
Human   509 RLKLKDGNRISLPSDF---QHKFTVQASPTMDKRKSLINS--RSSPPASPTIIPRLRA---IQCE 565

  Fly   840 DVRDLNTYSDVDSSCDTSLNYH------DVNN-----------------------------LPAA 869
            .|..::...:.......:|:.|      .::|                             :|..
Human   566 TVSQISWGQNTQGHLSPALSSHRLVQACSIHNFCHLSSTMCIYMHILTPGESSKTWGRSSVVPKE 630

  Fly   870 Q-EDENTVKP------------GKEELLEESTNKPSNQ----------ESQHHRLAIDDMRTRLN 911
            : |:|....|            |::||.......|..:          ||.|..|.:..:.....
Human   631 EGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYK 695

  Fly   912 QCRSKFEHLEEASRRNFNQSQHSMKNFFKTPPVALKMF---------------------QRLEHE 955
            |..|...:|.:..|     |..::..|.....:||...                     .||:|.
Human   696 QWSSSAPNLVKGPR-----SSPALPGFTSLMEMALLAASWVVPIDIEEDEDSEGPGSGESRLQHS 755

  Fly   956 AAALNGGNNCPPPP-------PRTQRINQ--TPIFGRKNPP-------------------VAIVG 992
            .:.   ...|.|.|       |.:..|::  ||:....:.|                   ||::|
Human   756 PSQ---SYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLG 817

  Fly   993 -QKLQHAESLE-DLASSGVAK--QLATPAPKRSKATATTKG--GQSSNPPLFLPPSLNISVALNS 1051
             ..:..|..|. ||..:|..:  .|..|.|...:.....:|  .:||.|
Human   818 CGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRP---------------- 866

  Fly  1052 NGNVTTTTNTNSSCPPSASDWLPKKHKLTLPLPSAQQQRTSSNHRLPMCNNKGKTLKPLPSRTGS 1116
                     ..|:.|||...:..::..|.|..|||.....|.: .:..||:....|:........
Human   867 ---------RRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLS-SISECNSTRSLLRSDSDEIVV 921

  Fly  1117 QGIPASNCVSPTRSSRPGSPTKHLAQRHTAATAQRLTNAAATHQQQHQQQSSKTTRLNILSPEKV 1181
            ..:|.|...:|     |.||..|          ..|.|......::...||...|.:.:.:|.:.
Human   922 YEMPVSPVEAP-----PLSPCTH----------NPLVNVRVERFKRDPNQSLTPTHVTLTTPSQP 971

  Fly  1182 HRLGARLTDQKQKMREEAAATASSVGGAGCAAGTAAGSLNGHRTIGSSGTPNSAVGERRRRAAPS 1246
            .  ..|.|.....::.|....:.|....|.:....||.|       .:.:|:...||..|...|:
Human   972 S--SHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGML-------KTPSPSRDPGEFPRLPDPN 1027

  Fly  1247 ---PPVRTHFNTR 1256
               ||....:||:
Human  1028 VVFPPTPRRWNTQ 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751
		PDZ_signaling	172..271	CDD:238492
		STKc_LIMK	407..693	CDD:271056	85/335 (25%)
MAP3K9	XP_011535090.1	SH3_MLK1-3	56..113	CDD:212992	10/61 (16%)
		STKc_MLK1	137..406	CDD:271047	83/317 (26%)
		TyrKc	144..403	CDD:197581	83/307 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910