DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LIMK1 and Lrrk

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster

Alignment Length:	818	Identity:	168/818 - (20%)
Similarity:	260/818 - (31%)	Gaps:	339/818 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 PMHSIRLVEIP---KDATPGLRVDGVAL---DDGCPTVRITDLFCNFFLWLTSMAEQCCGAPYRI 226
            |:...::.|:|   .:.|...|.||...   .||              :|              .
  Fly  1512 PILIFKIWEVPFQKTERTQPFRTDGNRFKLKQDG--------------IW--------------S 1548

  Fly   227 DVNLTN---LHIGDRILEVNGTPVSDSSVEQIDKLIRSN----EKMLQLTVEH------------ 272
            ||||::   |.:...:.|||.:...|.:..|:...||.:    .|:|.|||:|
  Fly  1549 DVNLSSSSILEVYFPLYEVNISQEVDDNERQLLAEIRPHMSQVAKLLALTVDHIDLLLEDWYPSL 1613

  Fly   273 --------------DPVQVCRSCS-QADIQRAMSASTLILPLSTSASSVEVGRERLYKT------ 316
                          ..:.:|..|. :..:|:....|...:|        .||..|..::
  Fly  1614 GTRFVHTSEGRFLITRLVLCPRCLWKLQLQQNNEPSDREVP--------PVGCNRPSRSSRRGAG 1670

  Fly   317 ---------PGEQG----------TKARKLRQATNA--------STTIPPAAGATAMTQLKEKER 354
                     |||.|          ..||:.|::.::        |...|.:||::..|.:
  Fly  1671 AYFLHGVGDPGEDGALNVFSAYLNATARRERRSEDSLGAGSDADSGVGPDSAGSSRNTSV----- 1730

  Fly   355 CSSLSKLLDEQHQAQQHSAHP---------------------QLYDLSRTQSCRVVQKPQRIFRA 398
                             ..||                     .:|:.|:. ||.|..:......|
  Fly  1731 -----------------DGHPGYHLPDNSNVCYAWMIEECILSVYNQSKI-SCPVHLEQSMAQLA 1777

  Fly   399 TDLVI----------------GEKLGEGFFGKVF----KVTHRQSGEVMVLKELH------RADE 437
            .|::.                |..||.|.||.||    ||...:|.:.:.:|.|.      ||.|
  Fly  1778 PDVIFADIPDKHTIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKE 1842

  Fly   438 EAQRNF----------------------IKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAG 480
            .|...|                      .:|:|||..|.|.:::..:|:..  |.|.:|.|....
  Fly  1843 SALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICI--KPLALVLELAPL 1905

  Fly   481 GCLKELI----HDPAQVLPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVRE--------- 532
            |.|..|:    ...|.:.|...:. |....|..:.|||...||:|||.|.|.||.|
  Fly  1906 GGLDALLRHYRRSGAHMGPHTFQT-LVLQAARAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDS 1969

  Fly   533 DRSVI---VADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVG 594
            .|:::   :||:|::|..    .|||   ..|:|                              |
  Fly  1970 PRNLVHIKIADYGISRQT----APSG---AKGFG------------------------------G 1997

  Fly   595 NPYWMAPEMMK---GLKYDEKVDVFSFGIMLCEII-------GRVEADPDFMPRNSDFSLNQQEF 649
            ...:||||:::   ..:|.||||.||||:.:.|.|       |. |:..:.:...|..:|.|:|
  Fly  1998 TEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGH-ESIKECILEGSRPALTQRE- 2060

  Fly   650 REKFCAQCPEPFVKVAFVCCDLNPDMRP-------------CFETLHV---------------WL 686
                 .|.|...:.:..:|....|..||             |...|.|               .|
  Fly  2061 -----TQFPTCCLDLMVLCWHEQPRRRPTASQIVSILSAPECIHLLDVVAMPHSEKIVCGVFQSL 2120

  Fly   687 QRLADDLAADRVPPERLLHEIETFQEWYASSEDALSPTSQRSLNNLDELVKSAVDSEISPVEKEK 751
            ..:.||        ||.  .:|.:...:.|..|.|..:...||...:. :..:...:::|
  Fly  2121 VGMGDD--------ERC--GLELWLPSFGSRIDILDCSPSGSLLQCNS-ISCSPQPQVAP----- 2169

  Fly   752 ENMVIKPQDIPKSPHLGKDFSPSGERLRDSMRARRRQR 789
                      ||:|..|.           :.|||..||
  Fly  2170 ----------PKTPENGA-----------NSRARSAQR 2186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751
		PDZ_signaling	172..271	CDD:238492	25/111 (23%)
		STKc_LIMK	407..693	CDD:271056	91/371 (25%)
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	87/342 (25%)
		STKc_LRRK	1801..2095	CDD:270902	86/340 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445214
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930