DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LIMK1 and cdi

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_524401.2	Gene:	cdi / 42289	FlyBaseID:	FBgn0004876	Length:	1213	Species:	Drosophila melanogaster

Alignment Length:	1031	Identity:	265/1031 - (25%)
Similarity:	379/1031 - (36%)	Gaps:	312/1031 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 PVQVC-RSCSQADIQRAMSASTLILP----LSTSASSVEVGRERLYKTPG----EQGTKARKLRQ 329
            |.::| .|..|.|   :.:||..|.|    :.|:|::|..      .|.|    |...|.:.|..
  Fly    12 PSEICGLSVDQVD---SSAASPFIWPSTAGMCTTATTVTT------STNGDATAEAPVKHQPLHN 67

  Fly   330 ATNASTTIPPAAGATAMTQLKEKERCSSLSKLLDEQHQAQQHSAHPQLYDLSRTQSCRVVQKPQR 394
            .......:|||    .:|:....:|                         |....|||.::....
  Fly    68 GGWIGNGLPPA----PVTRTISSDR-------------------------LVTGSSCRALRTAVS 103

  Fly   395 IFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLK--ELHRADEEAQRNFIKEVAVLRLLDHRH 457
            ...:.|..:.||:|.|||.:|:|||||.:|:|||||  :| ||:   :.|.::||.:|..|.|.:
  Fly   104 ALYSVDDFVKEKIGSGFFSEVYKVTHRTTGQVMVLKMNQL-RAN---RPNMLREVQLLNKLSHAN 164

  Fly   458 VLKFIGVLYKDKKLHMVTEYVAGGCLKELIHDPAQVLPWPQRVRLARDIACGMSYLHSMNIIHRD 522
            :|.|:||..::.:||.:|||:.||.|::|:.:...||...|::|||..||.||||:|...|.|||
  Fly   165 ILSFMGVCVQEGQLHALTEYINGGSLEQLLANKEVVLSATQKIRLALGIARGMSYVHDAGIFHRD 229

  Fly   523 LNSMNCLVR----EDRSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKS 583
            |.|.|.|:|    :....:|.|||||..:..
  Fly   230 LTSKNVLIRNLANDQYEAVVGDFGLAAKIPV---------------------------------- 260

  Fly   584 RQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQQE 648
            :.|:.|...||:|||::||.:||..||:..|||||||:.||||.|:|||||.|||.:.|.|:...
  Fly   261 KSRKSRLETVGSPYWVSPECLKGQWYDQTSDVFSFGIIQCEIIARIEADPDMMPRTASFGLDYLA 325

  Fly   649 FREKFCAQCPEPFVKVAFVCCDLNPDMRPCFETLHVWLQRLADDLAADRVPPERLLHEIETFQEW 713
            |.|......|..|:::||.||..:...||.|......|..|.          |:..||
  Fly   326 FVELCPMDTPPVFLRLAFYCCLYDAKSRPTFHDATKKLTLLL----------EKYEHE------- 373

  Fly   714 YASSEDALSPTSQRSLNNLDELVKSAVDSEISPVEKEKENMVIKPQ-DIPKSPHLGKDFSPSGER 777
               |....||.|...|.|            .||...:.||:.:.|: .:|....:..  :|:|
  Fly   374 ---SSAGASPLSSLELIN------------CSPGGSDSENVTLTPRASVPTVATICT--APAG-- 419

  Fly   778 LRDSMRARRRQRFLGAQEERRNLTPDTESKERALKKALKKCRPFGERGYLVDLRAGAELQLEDVR 842
               ::..|..|..    :|.....|..:|...||...     |.|..|
  Fly   420 ---TLTPRHLQEV----DEDGFRFPSKKSASAALPGT-----PNGSAG----------------- 455

  Fly   843 DLNTYSDVDSSCDTSLNYHDVNNLPAAQEDENTVKPGKEELLEESTNKPSNQESQHHRLAIDDMR 907
                    .|..|..:....|..  |.|:.|..:...:..|.|...:.|.      |....|..|
  Fly   456 --------SSGFDDHILKSRVRR--ATQKLEAEILLHRRSLSENIIHFPM------HTSPSDKAR 504

  Fly   908 TRLNQCRSKFEHLEEASRRNFNQSQHSMKNFFKTPPVALKMFQRLEHEAAALNGGNNCPPPPPRT 972
                 |     |..:..|    .|.||     .|||..|...|.         ...:.|.|||..
  Fly   505 -----C-----HQMQRQR----SSTHS-----PTPPRQLSSVQL---------PATSIPDPPPLP 541

  Fly   973 QRINQTPIFGRKNPPVAIV-----------------GQKLQHAESLEDLASSGVAKQL-ATPAPK 1019
            :.:          |.|..:                 |.|....|:|..|  .||.|.| |.|
  Fly   542 KPV----------PAVLTLRKVGDPQYKPTSEKDHNGSKPNPFEALAQL--RGVKKILDANP--- 591

  Fly  1020 RSKATATTKGGQSSNPPLFLPPSLNISVALNSNGNV---------TTTTNTNSSCPPSASDWLP- 1074
              |..|...|...|:....|.|......|:.|....         |:|.|..|:..||....||
  Fly   592 --KTYAAGVGDLFSSCFEMLAPFFKELAAMQSKAGAQGGGTSTEETSTGNKASAATPSEPKSLPV 654

  Fly  1075 -----KKH---KLTLP------LPSAQQQRTSSNHRLPM-------CNNKGKTLKPLPSRTGSQG 1118
                 :|:   :|.||      .|.|.......:..||.       ||::|:.    |...|
  Fly   655 SPHMTRKYSAIELRLPQRISNAAPPAVTSAPPPSIALPTDEDDCDDCNSEGED----PDGGG--- 712

  Fly  1119 IPASNCVSPTRSS-----RPGS-PT----------KHLAQRHTAATAQRLTNAAATHQQQHQQQS 1167
                ||.....||     ||.: ||          .|...|.:..|:.:.|:..........:.|
  Fly   713 ----NCADAESSSDDSAVRPSTVPTARKYRANSLYAHPLFRGSNGTSMKSTSTGEFESPTLLKAS 773

  Fly  1168 SKTTRLNILSPEKVHRLGAR-----LTDQKQKMREEAAATASSVGGA------GCA 1212
            :.|..|..       .:||.     ||:..:|.:|:|::.|::...|      ||:
  Fly   774 ASTITLTA-------SVGATNSCEDLTESARKSKEQASSGATAAVQALPTPMSGCS 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751
		PDZ_signaling	172..271	CDD:238492
		STKc_LIMK	407..693	CDD:271056	114/291 (39%)
cdi	NP_524401.2	TyrKc	113..363	CDD:197581	114/287 (40%)
cdi	NP_524401.2	PKc_like	116..370	CDD:304357	115/301 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445224
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119463at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR46485
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950