DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LIMK1 and wnd

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_649137.3	Gene:	wnd / 40143	FlyBaseID:	FBgn0036896	Length:	977	Species:	Drosophila melanogaster

Alignment Length:	1008	Identity:	205/1008 - (20%)
Similarity:	331/1008 - (32%)	Gaps:	354/1008 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   345 AMTQLKEKERCSSLSKLLDEQHQAQQHSAHPQLYDLSRTQSCRVVQKPQ-----RIFRATDLVIG 404
            |.|.|..|      |..||...:.|.|:.:.::.|.|...:|:....|.     ..|...|..||
  Fly    64 AATDLPFK------SSDLDSPPRLQHHNNYAEITDSSAENTCQQRWPPHVGGAGAAFGHPDKPIG 122

  Fly   405 ------------------------------------------EKLGEGFFGKVFKVTHRQSGEVM 427
                                                      |.||.|..|.||  :.|...|.:
  Fly   123 WMYGLLGCMKPVLSFIGKTGVIEVKSQRSEDWQIPFESITELEWLGSGAQGAVF--SGRLKNETV 185

  Fly   428 VLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELIHDPAQ 492
            .:|::    :|.:...||.   ||.|||.:::||.||..:.....::.|:...|.|:.::.:...
  Fly   186 AVKKV----KELKETDIKH---LRKLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKEEQV 243

  Fly   493 VLPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGLARSVDAPRLPSGNM 557
            :|| .:.|..::.||.||.||||..||||||.|.|.|:..:..|.::|||.:|..:
  Fly   244 MLP-SRLVSWSKQIALGMQYLHSHKIIHRDLKSPNILISTNEVVKISDFGTSREWN--------- 298

  Fly   558 TPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIML 622
                     .....||.:||:.                  |||||:::.....||||::|:|::|
  Fly   299 ---------EISTKMSFAGTVA------------------WMAPEVIRNEPCSEKVDIWSYGVVL 336

  Fly   623 CEIIGRVEADPDFMPRNSDFSLNQQEFREKFCAQCPEPFVKVAFVCCDLNPDMRPCFETLHVWLQ 687
            .|::.......|.......:.:.....:....:.|||.|..:..:|....|..||.|..:   |.
  Fly   337 WEMLTCEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQI---LS 398

  Fly   688 RLADDLAADRVPPERLLHEIETFQEWYASSEDALSPTSQRSLN------NL-------------- 732
            .|  |:|...:..:......||.:.|.......|...:|...|      :|
  Fly   399 HL--DIAGPELLRKTEKQYFETQKSWKEEVRSHLKEITQNGTNIHKYEQDLIKRRTAEWRHAQDI 461

  Fly   733 -----DELVK--------SAVDSEISPVEKEKENMVIKPQDIPKSPHLGKDFSPS---GERLRDS 781
                 |:|.|        |...|::.  ||||| :..:.:.:|     |..:.|:   |..:|..
  Fly   462 RMVYEDKLQKTNQLFFELSECMSQLQ--EKEKE-IAERERKLP-----GSGYKPNRRFGNTIRKM 518

  Fly   782 MRARRRQRFLGAQEERRNLTPDTESKERALKKALKKCRPFGERGYLVDLRAGAELQLEDVRDLNT 846
            ...|||.....|..::::.|||.|:...:..|.:                              .
  Fly   519 QHYRRRLNPAPAAIQQQSTTPDPETTPESPVKCM------------------------------L 553

  Fly   847 YSDVDSSCDTS---LNYHDVNNLPAAQEDENTVKPGKEELLEESTNKPSNQESQHHRLAIDDMRT 908
            |:.:||:|...   .|....:.|.|...::|
  Fly   554 YAQLDSNCQPKSYLANIIPSSGLGAPMPNKN---------------------------------- 584

  Fly   909 RLNQCRSKFEHLEEASRRNFNQSQHSMKNFFKTPPVALKMFQRLEHEAAALNGGNNCPPPPPRTQ 973
                 :..|.|     |||.:.|       |..||                      ...|.|.:
  Fly   585 -----KKVFRH-----RRNASGS-------FGAPP----------------------KYSPTRDR 610

  Fly   974 RINQTPIFGRKNPPVAIVGQKLQHAESLE----DLASSGVA---KQLATPAP------------- 1018
            |....|    :|..|.:|.::.| .::::    |::.|..|   :.:..|.|
  Fly   611 RYQSEP----ENRKVQLVERQTQ-TDAMDVSETDISPSAEAPRSQPIDVPVPNHRQLPLQLQRVQ 670

  Fly  1019 KRSKATATTKGGQSSNPPLFLPPSLNISVALNSNGNVTTTTNTNSSCPPSASDWLPKKHKLTLPL 1083
            |.::|.|..:.|.:|:....:.|      |..||||..:|:........|:.|.|
  Fly   671 KIAQAQARARSGSTSSAAGAVNP------ACPSNGNSLSTSELTYQDACSSPDQL---------- 719

  Fly  1084 PSAQQQRTSSNHRLPM--CNNKGKTLKPL---------PSRTGSQGIPASNCVSPTRSSRPGSPT 1137
               .....:||.||.|  |.:..:.|:.|         .:|...|.  .:|.||...:...|:..
  Fly   720 ---IDDVMNSNERLDMTECCSDNENLERLGRKVIEFINENRLSIQS--NTNSVSNADNGNGGASP 779

  Fly  1138 KHLAQRHTAATAQRLTNAAATHQ---------------------QQHQQQSSKTTRLNILSPEKV 1181
            ..|.:   :..:..|:..::||.                     :.|:|.|        .|.|:
  Fly   780 LELRE---SGNSPCLSRCSSTHSKRRKHPLGDNPNGSSIGNANGESHEQDS--------WSDEE- 832

  Fly  1182 HRLGARLTDQKQKMREEAAATASSVGGAGCAAG 1214
                ...||.|..:|..      |:|....|.|
  Fly   833 ----GETTDYKYALRRR------SIGRQPIARG 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751
		PDZ_signaling	172..271	CDD:238492
		STKc_LIMK	407..693	CDD:271056	78/285 (27%)
wnd	NP_649137.3	STYKc	161..400	CDD:214568	78/287 (27%)
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	79/286 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445216
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840