DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LIMK1 and LIMK2

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_001026971.1	Gene:	LIMK2 / 3985	HGNCID:	6614	Length:	686	Species:	Homo sapiens

Alignment Length:	748	Identity:	289/748 - (38%)
Similarity:	410/748 - (54%)	Gaps:	144/748 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 DCFRCSVCEGHLHNWYFEREGLLYCREDYYGRFGDACQQCMAVITGPVMVAGEHKFHPECFCCTA 123
            |.||||.|:..|.|||:|::|.|||.:||:|:||:.|..|..::|||.|||||.|:|||||.|.:
Human    15 DLFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMS 79

  Fly   124 CGSFIGEGESYALVERSKLYCGQCYGKRSCQPADAKARITTAGKPM-HSIRLVEIPKDATPGLRV 187
            |...|.:|::||||:.:.||||:|:.:....|...:....:..:.: :|:.|:.:|. .|.|.|.
Human    80 CKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPA-TTEGRRG 143

  Fly   188 DGVALDDGC----PTVRITDLFCNFFLWLTSMAEQCCGAPYRIDVNLTN---LHIGDRILEVNGT 245
            ..|:::..|    .||::.::                   .|:.::..|   :|.||||||:|||
Human   144 FSVSVESACSNYATTVQVKEV-------------------NRMHISPNNRNAIHPGDRILEINGT 189

  Fly   246 PVSDSSVEQIDKLIRSNEKMLQLTVEHDPVQVCRSCSQADIQRAMSASTLILPLSTSA------S 304
            ||....||:::..|....:.|||.:|||||      ||...|..:.|.  :.|...:|      |
Human   190 PVRTLRVEEVEDAISQTSQTLQLLIEHDPV------SQRLDQLRLEAR--LAPHMQNAGHPHALS 246

  Fly   305 SVEVGRERLYKTPGEQGT-KARKLRQATNASTTIPPAAGATAMTQLKEKERCSSLSKLLDEQHQA 368
            :::. :|.|      :|| :.|.||::.:.|.:..|::         .||
Human   247 TLDT-KENL------EGTLRRRSLRRSNSISKSPGPSS---------PKE--------------- 280

  Fly   369 QQHSAHPQLY--DLSRTQSCRVVQK-PQRIFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLK 430
                  |.|:  |:||::|.|.... .|:|||..||:.||.||:||||:..||||:.:|:|||:|
Human   281 ------PLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMK 339

  Fly   431 ELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELIH--DPAQV 493
            ||.|.|||.|:.|:.||.|:|.|||.:||||||||||||||:::|||:.||.||:.:.  ||
Human   340 ELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDP--- 401

  Fly   494 LPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGLARSVDAPRLPSGNMT 558
            .||.|:||.|:.||.||:|||||.||||||||.|||::.|::|:||||||:|.:...|
Human   402 FPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEER------- 459

  Fly   559 PGGYGSGANSDAPMSPSGTLRRS-KSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIML 622
                     ..|||..:.|.:|: :...|::|||||||||||||||:.|..|||.||:|||||:|
Human   460 ---------KRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVL 515

  Fly   623 CEIIGRVEADPDFMPRNSDFSLNQQEFREKFC-AQCPEPFVKVAFVCCDLNPDMRP--------- 677
            |||||:|.||||.:||..||.||.:.|.|||. ..||..|..:|.:||.|.|:.|.
Human   516 CEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRAPPGAAGEGP 580

  Fly   678 -CFETLHVWLQRLADDLAADR--------VPPERLLHEIETFQEWYASSEDALSPTSQRSLNNL- 732
             |           |||....|        ..|:.|...: ..:||.......|....:..::.|
Human   581 GC-----------ADDEGPVRRQGKVTIKYDPKELRKHL-NLEEWILEQLTRLYDCQEEEISELE 633

  Fly   733 ---DELVKSAVDSEISPVEKEKENMV--IKPQD 760
               |||:.  ::|:.:...:.||.:|  .||.:
Human   634 IDVDELLD--MESDDAWASRVKELLVDCYKPTE 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750	16/28 (57%)
		LIM2_LIMK	95..148	CDD:188751	28/52 (54%)
		PDZ_signaling	172..271	CDD:238492	29/105 (28%)
		STKc_LIMK	407..693	CDD:271056	154/299 (52%)
LIMK2	NP_001026971.1	LIM	<15..44	CDD:295319	16/28 (57%)
		LIM2_LIMK2	46..104	CDD:188849	30/57 (53%)
		PDZ	131..215	CDD:278991	29/103 (28%)
		PKc_like	316..570	CDD:328722	150/272 (55%)
		PP1_inhibitor	564..686	CDD:283108	23/115 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	320	1.000	Domainoid score	I1238
eggNOG	1	0.900	-	-		E33208_3BEDK
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	532	1.000	Inparanoid score	I1215
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119463at33208
OrthoFinder	1	1.000	-	-		FOG0003618
OrthoInspector	1	1.000	-	-		otm41497
orthoMCL	1	0.900	-	-		OOG6_103981
Panther	1	1.100	-	-	LDO	PTHR46485
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2495
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.830