Protein Alignment LIMK1 and Tak1

DIOPT Version :10

• Sequence 1: NP_511139.2
• Gene: LIMK1 / 32207
• FlyBaseID: FBgn0283712
• Length: 1257
• Species: Drosophila melanogaster
• Sequence 2: NP_524080.1
• Gene: Tak1 / 39659
• FlyBaseID: FBgn0026323
• Length: 678
• Species: Drosophila melanogaster
• Alignment Length: 739
• Identity: 160/739 - (21%)
• Similarity: 278/739 - (37%)
• Gaps: 222/739 - (30%)

  Fly   399 TDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIG 463
            :::.:.||:|.|.:|.|.|...|.  :::.:||...:.|  |::..|||..|..:.|.:::...|
  Fly    17 SEITLREKVGHGSYGVVCKAVWRD--KLVAVKEFFASAE--QKDIEKEVKQLSRVKHPNIIALHG 77

  Fly   464 VLYKDKKLHMVTEYVAGGCLKELIHDP-------AQVLPWPQRVRLARDIACGMSYLHSMN---I 518
            :....:..:::.|:..||.|...:|..       |..:.|      ||..|.|::|||:|.   :
  Fly    78 ISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSW------ARQCAEGLAYLHAMTPKPL 136

  Fly   519 IHRDLNSMNCLV-REDRSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSK 582
            ||||:..:|.|: .:.|::.:.|||....       ...|.....||.|
  Fly   137 IHRDVKPLNLLLTNKGRNLKICDFGTVAD-------KSTMMTNNRGSAA---------------- 178

  Fly   583 SRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQQ 647
                           |||||:.:|.||.||.|:||:.|:|.|::.|.:   .|...::.:::..:
  Fly   179 ---------------WMAPEVFEGSKYTEKCDIFSWAIVLWEVLSRKQ---PFKGIDNAYTIQWK 225

  Fly   648 EF---REKFCAQCPEPFVKVAFVCCDLNPDMRPCFE-TLHVWLQRLADDLAADRVPPERLLHE-- 706
            .:   |......||:....:...|....|:.||..: .:.|..:.:.|...||:......:::
  Fly   226 IYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVMHEIVKDYTGADKALEYTFVNQQI 290

  Fly   707 --------IETFQEWYASSEDALSPTSQR-----SLN-NLDELV------------KSAVDSEIS 745
                    :....:..:|.|..|||:|.:     :.| |::.:.            .|:..|:|:
  Fly   291 VTKESDGTVAAQPDSLSSQEGELSPSSTQLTPTTAANANVNAIAISKTTTSSMTENTSSTSSDIT 355

  Fly   746 PVEK-EKEN-----MVIKPQD-IPKSPHLGKDFSPSGERLRDSMRARRRQRFLGAQEERRNLTPD 803
            |... :.:|     ||....| ||:        ..|.|...||.                |||..
  Fly   356 PTNSGQLDNNPLFYMVTNRWDAIPE--------EESNESRNDSF----------------NLTSS 396

  Fly   804 TESKER--ALKKA--LKKCRPFGERGYLVDLRA-GAELQ-----------LEDVRDLNTYSD--- 849
            .|:.:|  .::..  |..|:|..:  ..:|:.| |.:|.           ..|.|:..|.:|
  Fly   397 AEATQRLETIRNGMILMACKPMEQ--LTLDVEANGFDLSPSESSSSSTNAKSDGRERLTVTDTKP 459

  Fly   850 VDSSCDTSLN----------------------------YHD---VNNLPA---AQEDENTVKPGK 880
            |..:.|.|.|                            .|:   ||:|..   ..||||   .|.
  Fly   460 VMMTTDLSNNNGGIHAHSNGLLSHANGWQARDEELQEQEHEQEIVNSLDVDVDPDEDEN---DGT 521

  Fly   881 EELLEESTNK--------PSNQESQ----HHR------LAIDDMRTRLNQCRS-KFEHLEEASRR 926
            |:.|.|..:.        |::.|||    .||      |::|   |.|...:. |.:.:.:..|.
  Fly   522 EQSLAEILDPELQPEPPIPNDAESQLIYRDHRHMAKEYLSVD---TNLYYAQDFKDKLIVQMDRT 583

  Fly   927 NFNQSQHSMKNFFKTPPVALKMFQRLEHEAAA--LNGGNNCPP-PPPRTQRINQTPIFGRKNPPV 988
            ...|.|..::. .|.......::..|:.:.|:  |..|::..| |.|...:: |.|   ..:||:
  Fly   584 EREQKQELLRK-MKDKEGLQSLYNNLQQQYASRQLAAGHHPQPHPHPHPNQL-QHP---HSHPPM 643

  Fly   989 ---------AIVGQKLQHAESLED 1003
                     .:.|.....:||:|:
  Fly   644 HFLQDEGCGLLPGSVCGGSESVEE 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751
		PDZ_LIMK-like	169..274	CDD:467236
		STKc_LIMK	407..693	CDD:271056	72/300 (24%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	72/300 (24%)