DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LIMK1 and Map3k9

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	XP_017170611.1	Gene:	Map3k9 / 338372	MGIID:	2449952	Length:	1120	Species:	Mus musculus

Alignment Length:	1074	Identity:	221/1074 - (20%)
Similarity:	365/1074 - (33%)	Gaps:	297/1074 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 GEQGTKARKLRQATN--ASTTIPPAAGATAMTQLKEKERCSSLSKLLDEQHQAQQHSAHP--QLY 378
            |::|....:|.|...  .|..:.|.:..::        ||         |..|:..|.:|  ||.
Mouse    83 GDEGWWTGQLNQRVGIFPSNYVTPRSAFSS--------RC---------QPGAEDPSCYPPIQLL 130

  Fly   379 DLSRTQSCRVVQKPQRIFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQR-- 441
            ::.                ..:|.:.|.:|.|.||||:: ......||.|....|..||:..:
Mouse   131 EID----------------FAELTLEEIIGIGGFGKVYR-AFWAGDEVAVKAARHDPDEDISQTI 178

  Fly   442 -NFIKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELIHD---PAQVLPWPQRVRL 502
             |..:|..:..:|.|.:::...||..|:..|.:|.|:..||.|..::..   |..:|     |..
Mouse   179 ENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDIL-----VNW 238

  Fly   503 ARDIACGMSYLHS---MNIIHRDLNSMNCLVRE--------DRSVIVADFGLARSVDAPRLPSGN 556
            |..||.||:|||.   :.||||||.|.|.|:.:        ::.:.:.||||||.
Mouse   239 AVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE---------- 293

  Fly   557 MTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIM 621
                     .:....||.:||..                  |||||:::...:.:..||:|:|::
Mouse   294 ---------WHRTTKMSAAGTYA------------------WMAPEVIRASMFSKGSDVWSYGVL 331

  Fly   622 LCEII-GRVEADPDFMPRNSD-----FSLNQQEFREKFCAQCPEPFVKVAFVCCDLNPDMRPCF- 679
            |.|:: |.|..      |..|     :.:...:......:.|||||.|:...|.:.:|..||.|
Mouse   332 LWELLTGEVPF------RGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFT 390

  Fly   680 -------------------ETLHV----W---LQRLADDLAADRVPPERLLHEIETFQEWYASSE 718
                               ::.|.    |   :|.:.|.|.|..       .|:.|::|  ..:.
Mouse   391 SILDQLTTIEESGFFEMPKDSFHCLQDDWKHEIQEMFDQLRAKE-------KELRTWEE--ELTR 446

  Fly   719 DALSPTSQRSLNNLDELVKSAVDSEISPVEKEKENMVIKP--QDIPKSPHLGKDFSPSGERLRDS 781
            .||...:|..|  |....:...:.||..:|:|. |::|..  |:.|:.......|..|..:|:|.
Mouse   447 AALQQKNQEEL--LRRREQELAEREIDILEREL-NIIIHQLCQEKPRVKKRKGKFRKSRLKLKDG 508

  Fly   782 MRARRRQRFLGAQEERRNLTPDTESKERALKKALKKCRPFGERGYLVDLRAGAELQLEDVRDLNT 846
            .|......|   |.:.......|..|.::|  ...:..|......:..|||   :||.......|
Mouse   509 NRISLPSDF---QHKFTVQASPTMDKRKSL--ISNRSSPPASPTIIPRLRA---IQLTPGESSKT 565

  Fly   847 YSDVDSSCDTSLNYHDVNNLPAAQEDENTVKPGKEELLEESTNKPSNQE--------SQHHRLAI 903
            :.                        .::|.| |||..||....|..:.        .|....:.
Mouse   566 WG------------------------RSSVVP-KEEGEEEEKRAPKKKGRTWGPGTLGQKELTSG 605

  Fly   904 DDMRTRLNQCRSKFEHLEEASRRNFNQSQHSMKNFFKTPPVALKM--------FQRLEHEAAALN 960
            |:..........:...||..:.:::..|......:|..|.:||..        :::....|..|.
Mouse   606 DEGVNGFGSLSMRNRSLEGEAEKHYEWSGRGHFCWFICPMLALHCSLKSLVDGYKQWSSSAPNLG 670

  Fly   961 GGNNCPPPPPRTQRI-------NQTPIFG----RKNPPVAIVGQKLQHAESLEDLASSGVAKQ-- 1012
            .|....|..|....:       ::.|..|    :.:|..:.:.......|..:..:|.||.::
Mouse   671 KGPRSSPALPGFTSLMEIEDEDSEGPGSGENHQQHSPNQSYLCIPFPRGEDGDGPSSDGVHEEPT 735

  Fly  1013 ---LATPAPKRSKATATTKGGQSSNPPLFLPPSLNISVALNSNGNVTTTTNTN------SSC--- 1065
               .||..|:.:...:..:||....         ...|||...|.|...|...      ..|
Mouse   736 PVNSATSTPQLTPTNSLKRGGTHHR---------RCEVALLGCGAVLAATGLGFDLLEAGKCQLL 791

  Fly  1066 PPSASDWLPKKHKLTLPLPSAQQQRTSSNHRLPMCNNKGKTLKPLPSR---------------TG 1115
            ||..            |.|.|::::..........:...::..| |||               :.
Mouse   792 PPEE------------PEPPAREEKKRREGLFQRASRPRRSTSP-PSRKLFKKEEPMTLLGDPSA 843

  Fly  1116 SQGIPASNCVSPTRSSR---------------PGSPTKHLAQRHTAATAQRLTNAAATHQQQHQQ 1165
            |..:.:.:.:|...|:|               |.||.:  |...|..|...|.|......::...
Mouse   844 SLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVE--APPLTQCTHNPLVNVRVERFKRDPN 906

  Fly  1166 QSSKTTRLNILSPEKVHRLGARLTDQKQKMREEAAATASSVGGAGCAAGTAAGSLNGHRTIGSSG 1230
            ||...|.:.:.:|.:..  |.|.|.....::..||.         ...|:.:.|.||......:|
Mouse   907 QSLTPTHVTLTAPTQPS--GHRRTPSDGALKPTAAP---------AVLGSRSPSSNGMSPSPGTG 960

  Fly  1231 -----TPNSAVGERRRRAAPS---PPVRTHFNTR 1256
                 :|:...||..|...|:   ||....:||:
Mouse   961 MLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQ 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751
		PDZ_signaling	172..271	CDD:238492
		STKc_LIMK	407..693	CDD:271056	85/335 (25%)
Map3k9	XP_017170611.1	SH3_MLK1-3	49..106	CDD:212992	5/22 (23%)
Map3k9	XP_017170611.1	STKc_MLK1	130..399	CDD:271047	83/333 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910